Toxicology and Drugs
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Questions and Answers

Which drug is known to cause 'red man syndrome'?

  • Amphotericin B (correct)
  • Vancomycin
  • Erythromycin
  • Sulfonamides
  • What is the mechanism of action of a certain antimycobacterial agent similar to INH?

  • Ethionamide (correct)
  • Capreomycin
  • Isoniazid
  • Para-aminosalicylic acid
  • What is the antidote for INH poisoning?

  • Pyridoxine (correct)
  • Ethylene glycol
  • PZA
  • None of the above
  • Q fever is caused by which bacterium?

    <p>Coxiella burnetti</p> Signup and view all the answers

    What is the classification of Q fever?

    <p>All of the above</p> Signup and view all the answers

    What type of asphyxiants exert a space-occupying effect?

    <p>Simple asphyxiants</p> Signup and view all the answers

    Which of the following is an antimycobacterial agent?

    <p>Ethionamide</p> Signup and view all the answers

    What is BZ?

    <p>An incapacitating chemical warfare agent</p> Signup and view all the answers

    Which antibiotic causes disulfiram like effects?

    <p>Metronidazole</p> Signup and view all the answers

    What is Methamphetamine also known as?

    <p>All of the above</p> Signup and view all the answers

    What is used in sports to help athletes make a certain weight?

    <p>Diuretics</p> Signup and view all the answers

    Which food has the highest tyramine effect?

    <p>Aged, mature cheese</p> Signup and view all the answers

    What is used to buffer lactic acidosis caused by exercise?

    <p>Sodium bicarbonate</p> Signup and view all the answers

    Which vitamin reduces iron from ferric to ferrous?

    <p>Vitamin C</p> Signup and view all the answers

    What is known as “soda loading”?

    <p>Sodium bicarbonate loading</p> Signup and view all the answers

    Food interaction occurs when pharmacologically active dietary monoamines such as which of the following is ingested by patients taking MAOIs?

    <p>Tyramine</p> Signup and view all the answers

    What is Vinblastine associated with?

    <p>Bradycardia, hypotension, and edema</p> Signup and view all the answers

    Which of the following is not a proton pump inhibitor?

    <p>Metronidazole</p> Signup and view all the answers

    What is the primary use of N-acetylcysteine?

    <p>Treatment of paracetamol poisoning</p> Signup and view all the answers

    What is the cause of filariasis?

    <p>Wuchereria bancrofti and Brugia malay</p> Signup and view all the answers

    What is the purpose of Diethylcarbamazine in filariasis treatment?

    <p>Eradication of the microfilaria</p> Signup and view all the answers

    What is Cellcept®?

    <p>A prodrug converted to the active drug in the liver</p> Signup and view all the answers

    What is the indication for N-acetylcysteine?

    <p>Mucolytic agent</p> Signup and view all the answers

    Which of the following is a cell cycle phase-specific agent?

    <p>Vinblastine</p> Signup and view all the answers

    What is the result of biotransformation of a drug?

    <p>The product is less lipid-soluble than the original drug</p> Signup and view all the answers

    What is the effect of Physostigimine and bethanechol on the neuromuscular junction?

    <p>Stimulation of the neuromuscular junction</p> Signup and view all the answers

    What is the likely cause of postural and exercise hypotension, diarrhea, and problems with ejaculation?

    <p>Guanethidine therapy</p> Signup and view all the answers

    What is the effect of Captopril and Enalapril on renin concentration in the blood?

    <p>Increase renin concentration in the blood</p> Signup and view all the answers

    What is the loading dose required to achieve a therapeutic plasma concentration of 4 mg/L immediately for Mr. Jones?

    <p>115.2 mg</p> Signup and view all the answers

    What is the effect of Physostigimine and bethanechol on gastric secretion?

    <p>Decrease in gastric secretion</p> Signup and view all the answers

    What is the effect of Guanethidine therapy on cardiac rate?

    <p>Decrease in cardiac rate</p> Signup and view all the answers

    What is the effect of Prazosin therapy on papillary constriction?

    <p>Decrease in papillary constriction</p> Signup and view all the answers

    What is the result of chronic exposure to a certain metal?

    <p>Hyperpigmentation and hyperkeratosis of the palm and soles</p> Signup and view all the answers

    Which toxin is produced by puffer fish?

    <p>Tetrodotoxin</p> Signup and view all the answers

    What is another name for dimercaprol?

    <p>BAL</p> Signup and view all the answers

    What is a natural compound derived from Urginea maritime?

    <p>Rotenone</p> Signup and view all the answers

    What is the name of a mixture of copper and arsenic salt used to control insects?

    <p>Paris green</p> Signup and view all the answers

    Which of the following is a polycyclic aromatic hydrocarbon found in cigarette smoke?

    <p>Benzopyrene</p> Signup and view all the answers

    What is the name of a naturally occurring furan produced by the mold Fusarium solani?

    <p>Ipomeanol</p> Signup and view all the answers

    Exposure to which vitamin can cause toxicity?

    <p>Vitamin A</p> Signup and view all the answers

    Study Notes

    Pharmaceuticals

    • Red man syndrome is caused by Vancomycin.
    • Sulfonamides can cause "red man red neck syndrome".
    • Erythromycin is not a causative agent of "red man red neck syndrome".
    • Amphotericin B is not a causative agent of "red man red neck syndrome".

    Antimycobacterial Agents

    • Ethionamide is a congener of INH and has the same mechanism of action as INH.
    • Capreomycin is an antimycobacterial agent.
    • Para-aminosalicylic acid is an antimycobacterial agent.
    • Pyrazinamide is an antimycobacterial agent.
    • Isoniazid is an antimycobacterial agent.

    Vitamin Therapy

    • Pyridoxine is a water-soluble vitamin used as an antidote for INH poisoning.
    • Pyridoxine is a water-soluble vitamin used as an antidote for Ethylene glycol poisoning.
    • Pyridoxine is a water-soluble vitamin used as an antidote for PZA poisoning.

    Toxicology

    • Hydrogen cyanide is a chemical asphyxiant.
    • Oxides of nitrogen are toxic combustion products that exert a space-occupying effect, displacing oxygen.
    • Hydrogen sulphide is a toxic gas.
    • Carbon dioxide is a toxic gas that exerts a space-occupying effect, displacing oxygen.

    Infections

    • Q fever is a self-limited, febrile, zoonotic disease contracted from domestic livestock.
    • Q fever is caused by Coxiella burnetii.
    • Methamphetamine is also known as speed, yaba, or go.

    Pharmacokinetics

    • Biotransformation (metabolism) usually results in a product that is less lipid-soluble than the original drug.
    • Biotransformation (metabolism) usually results in a product that is more likely to be excreted by the kidney.

    Antibiotics

    • Cefotetan causes disulfiram-like effects.
    • Metronidazole causes disulfiram-like effects.
    • Co-trimoxazole causes disulfiram-like effects.
    • Moxalactam causes disulfiram-like effects.

    Sports Pharmacy

    • Amphetamines are used in sports to enhance performance.
    • Sodium bicarbonate is used in sports to buffer lactic acidosis.
    • Diuretics are used in sports to enhance performance.
    • Caffeine is used in sports to enhance performance.

    Food Interactions

    • Aged, mature cheese has the highest tyramine effect.
    • Red wine has a high tyramine effect.
    • Avocados have a moderate tyramine effect.
    • Yogurt has a moderate tyramine effect.

    Vitamin Therapy

    • Vitamin C reduces iron from ferric to ferrous.
    • Vitamin C has a relaxing effect on gastrointestinal smooth muscle.
    • Vitamin C decreases gastric secretion.
    • Vitamin C reduces papillary constriction.

    Toxicology

    • Mercury is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
    • Arsenic is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
    • Lead is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
    • Cadmium is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.

    Insecticides

    • Bordeaux is a mixture of copper and arsenic salt used to control insects in the 1800s.
    • Rotenone is a natural compound derived from Urginea maritime and is effective in controlling rodents.
    • Pyrethrin is a natural compound derived from Chrysanthemum flowers and is effective in controlling insects.

    Other

    • Biotin is a vitamin that is present in Cluviscol tablets.
    • Vitamin D2 is present in Cluviscol tablets.
    • Calcium is present in Cluviscol tablets.
    • Ferrous fumarate is present in Cluviscol tablets.
    • Vitamin C is present in Cluviscol tablets.
    • Cobalt is present in Cluviscol tablets.

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    Description

    This quiz covers toxic substances, including gases and drugs, and their effects on the body. Questions range from identifying specific toxins to understanding their impact on human health.

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