40 Questions
Which drug is known to cause 'red man syndrome'?
Amphotericin B
What is the mechanism of action of a certain antimycobacterial agent similar to INH?
Ethionamide
What is the antidote for INH poisoning?
Pyridoxine
Q fever is caused by which bacterium?
Coxiella burnetti
What is the classification of Q fever?
All of the above
What type of asphyxiants exert a space-occupying effect?
Simple asphyxiants
Which of the following is an antimycobacterial agent?
Ethionamide
What is BZ?
An incapacitating chemical warfare agent
Which antibiotic causes disulfiram like effects?
Metronidazole
What is Methamphetamine also known as?
All of the above
What is used in sports to help athletes make a certain weight?
Diuretics
Which food has the highest tyramine effect?
Aged, mature cheese
What is used to buffer lactic acidosis caused by exercise?
Sodium bicarbonate
Which vitamin reduces iron from ferric to ferrous?
Vitamin C
What is known as “soda loading”?
Sodium bicarbonate loading
Food interaction occurs when pharmacologically active dietary monoamines such as which of the following is ingested by patients taking MAOIs?
Tyramine
What is Vinblastine associated with?
Bradycardia, hypotension, and edema
Which of the following is not a proton pump inhibitor?
Metronidazole
What is the primary use of N-acetylcysteine?
Treatment of paracetamol poisoning
What is the cause of filariasis?
Wuchereria bancrofti and Brugia malay
What is the purpose of Diethylcarbamazine in filariasis treatment?
Eradication of the microfilaria
What is Cellcept®?
A prodrug converted to the active drug in the liver
What is the indication for N-acetylcysteine?
Mucolytic agent
Which of the following is a cell cycle phase-specific agent?
Vinblastine
What is the result of biotransformation of a drug?
The product is less lipid-soluble than the original drug
What is the effect of Physostigimine and bethanechol on the neuromuscular junction?
Stimulation of the neuromuscular junction
What is the likely cause of postural and exercise hypotension, diarrhea, and problems with ejaculation?
Guanethidine therapy
What is the effect of Captopril and Enalapril on renin concentration in the blood?
Increase renin concentration in the blood
What is the loading dose required to achieve a therapeutic plasma concentration of 4 mg/L immediately for Mr. Jones?
115.2 mg
What is the effect of Physostigimine and bethanechol on gastric secretion?
Decrease in gastric secretion
What is the effect of Guanethidine therapy on cardiac rate?
Decrease in cardiac rate
What is the effect of Prazosin therapy on papillary constriction?
Decrease in papillary constriction
What is the result of chronic exposure to a certain metal?
Hyperpigmentation and hyperkeratosis of the palm and soles
Which toxin is produced by puffer fish?
Tetrodotoxin
What is another name for dimercaprol?
BAL
What is a natural compound derived from Urginea maritime?
Rotenone
What is the name of a mixture of copper and arsenic salt used to control insects?
Paris green
Which of the following is a polycyclic aromatic hydrocarbon found in cigarette smoke?
Benzopyrene
What is the name of a naturally occurring furan produced by the mold Fusarium solani?
Ipomeanol
Exposure to which vitamin can cause toxicity?
Vitamin A
Study Notes
Pharmaceuticals
- Red man syndrome is caused by Vancomycin.
- Sulfonamides can cause "red man red neck syndrome".
- Erythromycin is not a causative agent of "red man red neck syndrome".
- Amphotericin B is not a causative agent of "red man red neck syndrome".
Antimycobacterial Agents
- Ethionamide is a congener of INH and has the same mechanism of action as INH.
- Capreomycin is an antimycobacterial agent.
- Para-aminosalicylic acid is an antimycobacterial agent.
- Pyrazinamide is an antimycobacterial agent.
- Isoniazid is an antimycobacterial agent.
Vitamin Therapy
- Pyridoxine is a water-soluble vitamin used as an antidote for INH poisoning.
- Pyridoxine is a water-soluble vitamin used as an antidote for Ethylene glycol poisoning.
- Pyridoxine is a water-soluble vitamin used as an antidote for PZA poisoning.
Toxicology
- Hydrogen cyanide is a chemical asphyxiant.
- Oxides of nitrogen are toxic combustion products that exert a space-occupying effect, displacing oxygen.
- Hydrogen sulphide is a toxic gas.
- Carbon dioxide is a toxic gas that exerts a space-occupying effect, displacing oxygen.
Infections
- Q fever is a self-limited, febrile, zoonotic disease contracted from domestic livestock.
- Q fever is caused by Coxiella burnetii.
- Methamphetamine is also known as speed, yaba, or go.
Pharmacokinetics
- Biotransformation (metabolism) usually results in a product that is less lipid-soluble than the original drug.
- Biotransformation (metabolism) usually results in a product that is more likely to be excreted by the kidney.
Antibiotics
- Cefotetan causes disulfiram-like effects.
- Metronidazole causes disulfiram-like effects.
- Co-trimoxazole causes disulfiram-like effects.
- Moxalactam causes disulfiram-like effects.
Sports Pharmacy
- Amphetamines are used in sports to enhance performance.
- Sodium bicarbonate is used in sports to buffer lactic acidosis.
- Diuretics are used in sports to enhance performance.
- Caffeine is used in sports to enhance performance.
Food Interactions
- Aged, mature cheese has the highest tyramine effect.
- Red wine has a high tyramine effect.
- Avocados have a moderate tyramine effect.
- Yogurt has a moderate tyramine effect.
Vitamin Therapy
- Vitamin C reduces iron from ferric to ferrous.
- Vitamin C has a relaxing effect on gastrointestinal smooth muscle.
- Vitamin C decreases gastric secretion.
- Vitamin C reduces papillary constriction.
Toxicology
- Mercury is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
- Arsenic is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
- Lead is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
- Cadmium is a toxic metal that can cause hyperpigmentation and hyperkeratosis of the palm and soles.
Insecticides
- Bordeaux is a mixture of copper and arsenic salt used to control insects in the 1800s.
- Rotenone is a natural compound derived from Urginea maritime and is effective in controlling rodents.
- Pyrethrin is a natural compound derived from Chrysanthemum flowers and is effective in controlling insects.
Other
- Biotin is a vitamin that is present in Cluviscol tablets.
- Vitamin D2 is present in Cluviscol tablets.
- Calcium is present in Cluviscol tablets.
- Ferrous fumarate is present in Cluviscol tablets.
- Vitamin C is present in Cluviscol tablets.
- Cobalt is present in Cluviscol tablets.
This quiz covers toxic substances, including gases and drugs, and their effects on the body. Questions range from identifying specific toxins to understanding their impact on human health.
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