Questions and Answers
What is the mechanism of action of camptothecin in inhibiting cancer cell replication?
What is the mechanism of action of etoposide in inhibiting cancer cell replication?
Which topoisomerase does camptothecin inhibit?
Which topoisomerase does etoposide inhibit?
Signup and view all the answers
What is the primary use of camptothecin and etoposide?
Signup and view all the answers
Study Notes
Camptothecin Mechanism of Action
- Camptothecin inhibits cancer cell replication by targeting and inhibiting topoisomerase I.
- It stabilizes the DNA-topoisomerase I complex after it cleaves the DNA strand, preventing the ligation reaction and leading to DNA damage.
- The accumulation of DNA breaks disrupts replication and transcription processes, ultimately triggering cell death.
Etoposide Mechanism of Action
- Etoposide inhibits cancer cell replication by targeting topoisomerase II.
- It interferes with the enzyme's ability to seal the double-stranded breaks it induces in DNA, leading to DNA damage accumulation.
- This damage results in cell cycle arrest and apoptosis in rapidly dividing cancer cells.
Topoisomerase Inhibition
- Camptothecin specifically inhibits topoisomerase I, which is responsible for relieving torsional strain in DNA during replication.
- Etoposide specifically inhibits topoisomerase II, which is responsible for managing DNA tangles and breaks during the replication process.
Primary Uses
- Camptothecin is primarily used in the treatment of various types of cancer, including colorectal and lung cancers.
- Etoposide is commonly used for treating testicular cancer, small cell lung cancer, and as part of combination chemotherapy regimens for several malignancies.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Description
Test Your Knowledge on Topoisomerase Inhibitors Used in Cancer Treatment" - Take this quiz to enhance your understanding of Camptothecin and Etoposide, two essential topoisomerase inhibitors utilized in inhibiting cancer cell replication. Learn how they work, their mechanisms of action, and the specific DNA sites they target. Test your knowledge with this quiz today!
