DNA Replication and Repair Quiz
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DNA Replication and Repair Quiz

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Questions and Answers

What is the role of nucleoside analogs in blocking DNA replication?

  • They slow the division of rapidly growing cells and viruses by promoting DNA replication
  • They block DNA replication by inhibiting the incorporation of certain nucleoside analogs (correct)
  • They have no impact on DNA replication or cell division
  • They enhance DNA chain growth by incorporating modified nucleosides

    • Which of the following is a correct statement about topoisomerase inhibitors?

  • Fluoroquinolones are used as antibiotics to inhibit prokaryotic topoisomerase II (correct)
  • Nalidixic acid and ciprofloxacin are used as anti-cancer treatments to inhibit eukaryotic topoisomerase II
  • Daunorubicin and doxorubicin are used as antiviral agents to inhibit prokaryotic topoisomerase II
  • Etoposide and teniposide are used as antibiotics to inhibit eukaryotic topoisomerase II

    • Which nucleoside analog is used in HIV treatment?

  • 2′,3′-dideoxyinosine ([ddI]) or didanosine
  • Adenine arabinoside (araA)
  • Cytosine arabinoside (araC)
  • AZidoThymidine (AZT) or zidovudine (correct)

    • How are thymine dimers eliminated from DNA?

    <p>By nucleotide excision repair mechanism</p> Signup and view all the answers

    What pathology is associated with defective repair of thymidine dimers?

    <p>Xeroderma pigmentosum</p> Signup and view all the answers

    Which of the following is an inhibitor of eukaryotic topoisomerase II used in anti-cancer treatment?

    <p>Etoposide</p> Signup and view all the answers

    What modification in the sugar portion of the nucleoside can block DNA replication and slow the division of rapidly growing cells?

    <p>Substitution of the hydroxyl group with N3</p> Signup and view all the answers

    What is the genetic disease characterized by extreme sensitivity to sunlight, skin freckling, ulcerations, and skin cancer?

    <p>Xeroderma pigmentosum</p> Signup and view all the answers

    Which nucleoside analog is used as an antiviral agent against herpes?

    <p>Adenine arabinoside (araA)</p> Signup and view all the answers

    What is the role of fluoroquinolones such as ciprofloxacin?

    <p>Inhibitors of prokaryotic topoisomerase II used as antibiotics</p> Signup and view all the answers

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