10 Questions
What is the role of nucleoside analogs in blocking DNA replication?
They block DNA replication by inhibiting the incorporation of certain nucleoside analogs
Which of the following is a correct statement about topoisomerase inhibitors?
Fluoroquinolones are used as antibiotics to inhibit prokaryotic topoisomerase II
Which nucleoside analog is used in HIV treatment?
AZidoThymidine (AZT) or zidovudine
How are thymine dimers eliminated from DNA?
By nucleotide excision repair mechanism
What pathology is associated with defective repair of thymidine dimers?
Xeroderma pigmentosum
Which of the following is an inhibitor of eukaryotic topoisomerase II used in anti-cancer treatment?
Etoposide
What modification in the sugar portion of the nucleoside can block DNA replication and slow the division of rapidly growing cells?
Substitution of the hydroxyl group with N3
What is the genetic disease characterized by extreme sensitivity to sunlight, skin freckling, ulcerations, and skin cancer?
Xeroderma pigmentosum
Which nucleoside analog is used as an antiviral agent against herpes?
Adenine arabinoside (araA)
What is the role of fluoroquinolones such as ciprofloxacin?
Inhibitors of prokaryotic topoisomerase II used as antibiotics
Test your knowledge of DNA replication and repair with this quiz. Learn about topoisomerase inhibitors and nucleoside analogs that can block DNA replication. Explore the use of these inhibitors as antibiotics and anti-cancer treatments.
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