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DNA Replication and Repair Quiz

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Questions and Answers

What is the role of nucleoside analogs in blocking DNA replication?

They slow the division of rapidly growing cells and viruses by promoting DNA replication

They block DNA replication by inhibiting the incorporation of certain nucleoside analogs (correct)

They have no impact on DNA replication or cell division

They enhance DNA chain growth by incorporating modified nucleosides

Which of the following is a correct statement about topoisomerase inhibitors?

Fluoroquinolones are used as antibiotics to inhibit prokaryotic topoisomerase II (correct)

Nalidixic acid and ciprofloxacin are used as anti-cancer treatments to inhibit eukaryotic topoisomerase II

Daunorubicin and doxorubicin are used as antiviral agents to inhibit prokaryotic topoisomerase II

Etoposide and teniposide are used as antibiotics to inhibit eukaryotic topoisomerase II

Which nucleoside analog is used in HIV treatment?

2′,3′-dideoxyinosine ([ddI]) or didanosine

Adenine arabinoside (araA)

Cytosine arabinoside (araC)

AZidoThymidine (AZT) or zidovudine (correct)

How are thymine dimers eliminated from DNA?

By nucleotide excision repair mechanism Signup and view all the answers

What pathology is associated with defective repair of thymidine dimers?

Xeroderma pigmentosum Signup and view all the answers

Which of the following is an inhibitor of eukaryotic topoisomerase II used in anti-cancer treatment?

Etoposide Signup and view all the answers

What modification in the sugar portion of the nucleoside can block DNA replication and slow the division of rapidly growing cells?

Substitution of the hydroxyl group with N3 Signup and view all the answers

What is the genetic disease characterized by extreme sensitivity to sunlight, skin freckling, ulcerations, and skin cancer?

Xeroderma pigmentosum Signup and view all the answers

Which nucleoside analog is used as an antiviral agent against herpes?

Adenine arabinoside (araA) Signup and view all the answers

What is the role of fluoroquinolones such as ciprofloxacin?

Inhibitors of prokaryotic topoisomerase II used as antibiotics Signup and view all the answers