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What is the significance of activating mutations in EGFR in non-small cell lung tumors?
What is the significance of activating mutations in EGFR in non-small cell lung tumors?
Activating mutations in EGFR in non-small cell lung tumors exhibit sensitivity to targeted tyrosine kinase inhibitors.
What is the role of double mutants in the resistance of NSCLC to gefitinib/erlotinib therapy?
What is the role of double mutants in the resistance of NSCLC to gefitinib/erlotinib therapy?
Double mutants exhibit significant gain-of-function characteristics that account for their initial presence prior to drug selection and their quick selection as the single drug resistance mutation during therapy with gefitinib/erlotinib.
Which subset of NSCLC is characterized by mutations in the kinase domain of the EGF receptor?
Which subset of NSCLC is characterized by mutations in the kinase domain of the EGF receptor?
Adenocarcinomas developing in nonsmokers are characterized by mutations in the kinase domain of the EGF receptor.
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