10 Questions
What is the main difference between regeneration and repair?
Regeneration replaces lost or damaged tissue with similar tissue, while repair replaces it with granulation tissue and scar tissue.
What is the helpful and not-so-helpful route of wound healing?
Healing through fibrosis/scar formation is not helpful, while healing through granulation tissue formation is helpful.
What is the main difference between primary and secondary intention wound healing?
In primary intention, re-epithelialization dominates the healing process, while in secondary intention, granulation tissue covers the wound and the wound area is reduced by contraction.
What is the main purpose of the hemostasis stage in the healing of a small skin wound?
To form a platelet plug and fibrin clot to stop bleeding.
What is the time period for the granulation tissue formation stage in the healing of a small skin wound?
2-5 days
What is the primary function of macrophages during the wound healing process?
All of the above
What is the primary difference between keloid and hypertrophic scarring?
Keloids spread beyond the margins of the original wound, while hypertrophic scars do not.
What is the primary mechanism of re-epithelialization in a small skin wound?
Proliferation of basal epithelial cells adjacent to the wound and their migration across the wound bed under the fibrin scab.
What is the primary function of the extracellular matrix during the maturation stage of connective tissue healing?
Decreased cellularity and vascularity
Which of the following is not a traditional function of macrophages during wound healing?
Stimulation of angiogenesis
Test your knowledge on tissue regeneration and repair processes. Learn about the differences between healing by primary and secondary intention, as well as the helpful and not-so-helpful routes of repair.
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