Healing and Repair in Pathology

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What is the primary difference between healing and regeneration?

Healing involves the replacement of injured cells with fibrous tissue, while regeneration involves the replacement of injured cells with cells of the same type.

What is the main component of granulation tissue?

Fibroblasts

What is the term for the process of wound healing in which the wound is closed immediately?

Primary intention

What is the factor that controls tissue regeneration?

<p>Biochemical factors</p> Signup and view all the answers

What is the complication of skin wound healing?

<p>Increased scarring</p> Signup and view all the answers

Which organ has a remarkable capacity to regenerate?

<p>Liver</p> Signup and view all the answers

Which cells carry away debris during the wound healing process?

<p>Macrophages and neutrophils</p> Signup and view all the answers

What is the timeframe for neutrophils to disappear and macrophages to enter the wound site during primary union?

<p>3 days</p> Signup and view all the answers

At what percentage of unwounded skin tensile strength is reached in 3 months during primary union?

<p>70-80%</p> Signup and view all the answers

What type of wound healing occurs when there is minimal or no skin loss?

<p>Healing by primary union</p> Signup and view all the answers

What is the role of fibroblasts during the wound healing process?

<p>Producing collagen</p> Signup and view all the answers

What type of wound healing occurs when large tissue defects need to be refilled or purulent infections prevent direct association of wound edges?

<p>Healing by secondary union</p> Signup and view all the answers

What is a common consequence of inadequate scar formation in wounds?

<p>Wound dehiscence</p> Signup and view all the answers

What is the primary reason for Mrs. W's wound on the sole of her right foot?

<p>Unknown aetiology</p> Signup and view all the answers

What is the characteristic of a hypertrophic scar?

<p>Excess collagen</p> Signup and view all the answers

What is the likely consequence of persistent infection at the wound site?

<p>Wound dehiscence</p> Signup and view all the answers

What is the correct sequence of wound healing phases in Mrs. W's case?

<p>Inflammation, haemostasis, proliferation, and maturation</p> Signup and view all the answers

What is the likely underlying cause of Mrs. W's cellulitis?

<p>Wound infection</p> Signup and view all the answers

What is the primary purpose of the inflammation phase in wound healing?

<p>To clear dead cells and microbes</p> Signup and view all the answers

During which phase of wound healing is vascularized granulation tissue formed?

<p>Repair</p> Signup and view all the answers

What percentage of the strength of normal skin do carefully sutured wounds have?

<p>70%</p> Signup and view all the answers

When are sutures usually removed in a clean wound post-surgery?

<p>After 1 week</p> Signup and view all the answers

What is the approximate strength of the wound when sutures are removed?

<p>10% of that of unwounded skin</p> Signup and view all the answers

How long does it take for the wound to reach its maximum immediate strength after surgery?

<p>13-18 days</p> Signup and view all the answers

During the initial 2 months of wound healing, what is the primary reason for the recovery of tensile strength?

<p>Excess of collagen synthesis over collagen degradation</p> Signup and view all the answers

What percentage of normal wound strength is typically reached by 3 months after injury?

<p>70% to 80%</p> Signup and view all the answers

Which cell type is responsible for the most serious consequences of a stroke?

<p>Permanent cells</p> Signup and view all the answers

What is the primary reason why neurons and cardiac muscle cells cannot regenerate after injury?

<p>They are terminally differentiated and non-proliferative</p> Signup and view all the answers

What is the outcome of injury to permanent cells, such as neurons and cardiac myocytes?

<p>Irreversible scarring</p> Signup and view all the answers

At later stages of wound healing, what structural modifications contribute to the recovery of tensile strength?

<p>Crosslinking and increased fiber size</p> Signup and view all the answers

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