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Plasminogen Activation Quiz

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Questions and Answers

What is the role of endothelial cells in preventing inappropriate thrombi formation?

Mediating platelet adhesion to exposed subendothelium

Containing binding sites for von Willebrand Factor (vWF)

Expressing collagen and tissue factor

Releasing tissue plasminogen activator and urokinase (correct)

Which factor is deficient in Hemophilia C?

Factor II

Factor IIa

Factor XIII

Factor XI (correct)

What is the main function of von Willebrand Factor (vWF) in the formation of the platelet plug?

Gluing platelets together by fibrinogen

Exposing thrombin (T) to activate platelets

Shutting off the coagulation cascade in the presence of Factor IIa (thrombin)

Mediating platelet adhesion to exposed subendothelium (correct)

What triggers the activation of platelets after binding to the subendothelial tissue?

Exposure of thrombin (T) Signup and view all the answers

Which component is expressed by subendothelium to kick off the coagulation cascade?

Collagen Signup and view all the answers

What is the function of activated Protein C?

Inhibiting Factors V and VIII Signup and view all the answers

What is the physiological inhibitor that activates Protein C?

Activated Thrombomodulin Signup and view all the answers

In what form does Protein S exist in the circulation?

Complex form bound to Protein C Signup and view all the answers

What is the function of Protein S?

Regulating anticoagulation and inflammation Signup and view all the answers

Which enzyme activates Protein C?

Thrombin Signup and view all the answers

Which factor functions as a cofactor in the blood coagulation cascade for the proteolytic activation of factor X by factor IXa?

Factor VIII (FVIII) Signup and view all the answers

What is the main role of Thromboxane A2 (TXA2) in platelet activation?

Recruitment of additional platelets to the site of injury Signup and view all the answers

Which molecule is the inactive hydrolysis product of prostacyclin (PGI2)?

6 keto PGF1 alpha Signup and view all the answers

What is the most potent endogenous inhibitor of platelet aggregation so far discovered?

Prostacyclin (PGI2) Signup and view all the answers

What does protein C do in the blood coagulation cascade?

Inhibits thrombin generation Signup and view all the answers