Questions and Answers
What is the brand name of Tiotropium?
What is the generic name of Spiriva?
Tiotropium
What are the indications for Tiotropium?
For the long-term, once-daily, maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema and for reducing exacerbations
What is the recommended dosing for Tiotropium?
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What strength of Tiotropium is delivered per dose?
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What class of medication is Tiotropium?
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What is the mechanism of action of Tiotropium?
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What drug interactions should be considered with Tiotropium?
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Which of the following are common side effects of Tiotropium? (Select all that apply)
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What is one of the contraindications for using Tiotropium?
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What should be done if a dose of Tiotropium is missed?
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Study Notes
Brand and Generic Names
- Brand name: Spiriva
- Generic name: Tiotropium
Indications
- Long-term maintenance treatment of bronchospasm associated with Chronic Obstructive Pulmonary Disease (COPD)
- Includes conditions like chronic bronchitis and emphysema
- Aims to reduce exacerbations
Dosing
- Recommended dose: One inhalation daily
Strengths and Dosage Forms
- Available as an inhalation powder
- Forms: HandiHaler and Respimat inhalers
- Each dose delivers 18 mcg tiotropium
Medication Class
- Classified as an antiasthmatic
Pharmacology
- Long-acting antagonist at M₃-receptors in bronchial smooth muscle
- Mechanism leads to bronchodilation lasting over 24 hours
Drug Interactions
- Concomitant use with CYP2D6 and CYP3A4 inhibitors may raise plasma levels of tiotropium
- Minimal metabolism reduces significance of these interactions
Side Effects/Adverse Effects
- Common side effects include:
- Dry mouth
- Upper respiratory infections
- Pharyngitis
- Sinusitis
- Chest pain
- Abdominal pain
- Constipation
- Vomiting
- Dizziness
- Rash
- Tachycardia
- Throat irritation
- Urinary Tract Infections (UTI)
Contraindications
- Hypersensitivity to atropine or derivatives
- Not for acute bronchospasm treatment (rescue therapy)
- Caution in renal impairment, narrow-angle glaucoma, prostatic hyperplasia, or bladder-neck obstruction
- Pregnancy Category C
Patient Counseling
- Store in a cool, dry place away from sunlight and out of children's reach
- Unused capsules should remain in the blister strip and used within two consecutive days
- If a dose is missed, take it as soon as possible unless close to the next dose
- Consult a physician if side effects are severe or persistent
- Intended for daily use for maximum efficacy
- HandiHaler usage instructions include:
- Open blister for one capsule
- Prepare the inhaler and insert the capsule correctly
- Exhale fully before inhalation
- Inhale slowly and deeply; repeat as needed
- Dispose of the empty capsule properly
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Description
Explore the essential information about Tiotropium in this quiz, focusing on its brand name, indications, dosing, and strength. Perfect for healthcare professionals and students seeking to deepen their understanding of this medication used for COPD treatment.
