Tiotropium Flashcards
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Questions and Answers

What is the brand name of Tiotropium?

  • Singulair
  • Symbicort
  • Spiriva (correct)
  • Advair
  • What is the generic name of Spiriva?

    Tiotropium

    What are the indications for Tiotropium?

    For the long-term, once-daily, maintenance treatment of bronchospasm associated with COPD, including chronic bronchitis and emphysema and for reducing exacerbations

    What is the recommended dosing for Tiotropium?

    <p>One inhalation daily</p> Signup and view all the answers

    What strength of Tiotropium is delivered per dose?

    <p>18 mcg</p> Signup and view all the answers

    What class of medication is Tiotropium?

    <p>Antiasthmatic</p> Signup and view all the answers

    What is the mechanism of action of Tiotropium?

    <p>Long-acting antagonist of the action of acetylcholine at the M₃-receptors in the smooth muscle of the bronchial tree</p> Signup and view all the answers

    What drug interactions should be considered with Tiotropium?

    <p>Drugs which inhibit CYP2D6 and CYP3A4 metabolic pathways may increase the plasma levels of Tiotropium.</p> Signup and view all the answers

    Which of the following are common side effects of Tiotropium? (Select all that apply)

    <p>Rash</p> Signup and view all the answers

    What is one of the contraindications for using Tiotropium?

    <p>Known hypersensitivity to atropine</p> Signup and view all the answers

    What should be done if a dose of Tiotropium is missed?

    <p>Take it as soon as possible, or skip if it's closer to the next dose.</p> Signup and view all the answers

    Study Notes

    Brand and Generic Names

    • Brand name: Spiriva
    • Generic name: Tiotropium

    Indications

    • Long-term maintenance treatment of bronchospasm associated with Chronic Obstructive Pulmonary Disease (COPD)
    • Includes conditions like chronic bronchitis and emphysema
    • Aims to reduce exacerbations

    Dosing

    • Recommended dose: One inhalation daily

    Strengths and Dosage Forms

    • Available as an inhalation powder
    • Forms: HandiHaler and Respimat inhalers
    • Each dose delivers 18 mcg tiotropium

    Medication Class

    • Classified as an antiasthmatic

    Pharmacology

    • Long-acting antagonist at M₃-receptors in bronchial smooth muscle
    • Mechanism leads to bronchodilation lasting over 24 hours

    Drug Interactions

    • Concomitant use with CYP2D6 and CYP3A4 inhibitors may raise plasma levels of tiotropium
    • Minimal metabolism reduces significance of these interactions

    Side Effects/Adverse Effects

    • Common side effects include:
      • Dry mouth
      • Upper respiratory infections
      • Pharyngitis
      • Sinusitis
      • Chest pain
      • Abdominal pain
      • Constipation
      • Vomiting
      • Dizziness
      • Rash
      • Tachycardia
      • Throat irritation
      • Urinary Tract Infections (UTI)

    Contraindications

    • Hypersensitivity to atropine or derivatives
    • Not for acute bronchospasm treatment (rescue therapy)
    • Caution in renal impairment, narrow-angle glaucoma, prostatic hyperplasia, or bladder-neck obstruction
    • Pregnancy Category C

    Patient Counseling

    • Store in a cool, dry place away from sunlight and out of children's reach
    • Unused capsules should remain in the blister strip and used within two consecutive days
    • If a dose is missed, take it as soon as possible unless close to the next dose
    • Consult a physician if side effects are severe or persistent
    • Intended for daily use for maximum efficacy
    • HandiHaler usage instructions include:
      • Open blister for one capsule
      • Prepare the inhaler and insert the capsule correctly
      • Exhale fully before inhalation
      • Inhale slowly and deeply; repeat as needed
      • Dispose of the empty capsule properly

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    Description

    Explore the essential information about Tiotropium in this quiz, focusing on its brand name, indications, dosing, and strength. Perfect for healthcare professionals and students seeking to deepen their understanding of this medication used for COPD treatment.

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