Tight Junctions in Cell Biology

Proteins that reside within the membrane of the tight junction, forming a seal between cells. Examples include occludin, claudin, and JAMs.

Proteins located on the inside of the cell membrane, acting as a structural framework for the tight junction. Examples include cingulin, symplekin, and ZO-1.

The way tight junction membrane proteins connect to neighboring cells. This creates a tight seal between the cells.

The strength and stability of tissues are enhanced by the close connection between cells provided by tight junctions.

Tight junctions act as a barrier that controls which molecules can pass through, preventing the movement of larger molecules and regulating the passage of smaller ones.

Tight junctions prevent the movement of membrane proteins and lipids between adjacent cells. This maintains distinct compositions in different areas of the cell membrane.

Tight junctions help maintain the proper distribution of proteins and molecules within the cell, contributing to its organized structure.

Tight junctions in the brain create a barrier that limits the movement of substances from blood to the brain, allowing only specific substances to enter.