29 Questions
What type of bacteria is tigecycline active against?
Vancomycin-resistant enterococci
What is tigecycline indicated for?
Treatment of complicated skin and soft-tissue infections
What is the primary route of elimination of tigecycline?
Biliary/fecal excretion
Why is tigecycline a poor option for bloodstream infections?
It achieves low plasma concentrations
What is a boxed warning associated with tigecycline?
It should be reserved for use in situations when alternative treatments are not suitable
What is a potential adverse effect of tigecycline therapy?
Acute pancreatitis
Which macrolide is effective against Haemophilus influenzae?
Clarithromycin
What is the property of Roxithromycin that makes it useful in treating infections caused by intracellular bacteria?
Its ability to highly concentrate in neutrophils and macrophages
Which of the following organisms is NOT typically targeted by Erythromycin?
Haemophilus influenzae
Which of the following macrolides is a long-acting acid stable derivative of Erythromycin?
Roxithromycin
What is the effect of Malaria on red blood cells?
It destroys them
Telithromycin is effective against which type of organisms?
Macrolide-resistant organisms
What is a risk factor for Pseudomonas aeruginosa infections?
Recent antibiotic exposure
What is the purpose of combining aminoglycosides with a β-lactam antibiotic?
To employ a synergistic effect
What is gentamicin effective in treating?
A rare lymphoid disease
What is a type of infection that can be treated with tobramycin alone?
Urinary tract infection
What is the purpose of adding aminoglycosides to β-lactams for select serious gram-positive infections?
To employ a synergistic effect
What is the mechanism of action of macrolide antibiotics?
Binding to a site on the 50S subunit of the bacterial ribosome and inhibiting translocation
Which antibiotic is considered an alternative in patients with penicillin allergy?
Roxithromycin
Which macrolide antibiotic exhibits greater activity against intracellular pathogens such as H. Pylori?
Azithromycin
Which antibiotic is a safe option for a pregnant woman with community-acquired pneumonia?
Azithromycin
What is the difference in spectrum of activity between erythromycin and azithromycin?
Azithromycin has better activity against respiratory pathogens
What is a characteristic of azithromycin compared to erythromycin?
Less potent activity against staphylococci and streptococci
What is the mechanism of action of quinupristin/dalfopristin?
By binding to separate sites on the 50S bacterial ribosome
What is the primary indication for the use of quinupristin/dalfopristin?
Severe infections caused by vancomycin-resistant Enterococcus (VRE)
What is the consequence of enzymatic modification of quinupristin/dalfopristin in some cases?
It converts the bactericidal action to bacteriostatic
What adverse effects have been reported with the administration of higher doses of quinupristin/dalfopristin?
Arthralgia and myalgia
What is the mechanism by which quinupristin/dalfopristin induces hyperbilirubinemia?
Inhibition of glucuronidation
What is the consequence of bacterial efflux pumps on quinupristin/dalfopristin?
Increased risk of resistance
Test your knowledge of Tigecycline, a broad-spectrum antibiotic, including its antibacterial spectrum and therapeutic indications. This quiz covers the antibiotic's activity against various bacteria and its use in treating complicated skin and intra-abdominal infections.
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