18 Questions
Which bacterial resistance mechanisms does Tigecycline overcome in relation to tetracyclines?
Efflux pump acquisition and ribosomal protection
How does Tigecycline act on bacteria to inhibit protein synthesis?
By binding to the 30S ribosomal subunit and blocking entry of Aminoacyl-tRNA
Which type of bacteria is Tigecycline effective against?
Gram-positive, Gram-negative, and anaerobes
What is the primary reason for not prescribing tetracyclines to children under 8 years of age?
Risk of permanent discoloration of teeth during tooth development
What class of antibiotics does Tigecycline belong to?
Glycylcyclines
Which antibiotic acts by inhibiting protein synthesis through forming a stable complex with elongation factor EF-G?
Fusidic acid
What is the mechanism of action of tetracyclines?
Reversibly binding to the 30S subunit of the ribosome at the A-site
Which antibiotic has a broad spectrum that covers atypical bacteria such as Mycoplasma and Chlamydia?
Doxycycline
What is a common side effect associated with tetracyclines?
Photosensitivity
Which antibiotic is less susceptible to inactivating enzymes due to its chemical structure?
Amikacin
Which antibiotic is used topically only and is not active against Pseudomonas aeruginosa?
Neomycin
Which antibiotic is effective against MRSA?
Doxycycline
Why should patients receiving tetracyclines be kept out of heavy sunlight?
To prevent photosensitivity reactions
Which tetracycline is excreted primarily in the intestinal tract?
Doxycycline
What is the main reason for the yellow discoloration of teeth associated with tetracycline use?
Affinity for calcium leading to teeth deposits
In what body fluids do tetracyclines reach high concentrations?
Tears and saliva
Which substance decreases the absorption of tetracyclines?
Calcium
What impact do tetracyclines have on normal flora in the body?
Cause superinfections by modifying normal flora
Learn about Tigecycline, a unique antibiotic that overcomes major bacterial resistance mechanisms related to tetracyclines. Explore its FDA approval, administration, and contraindications including allergies, renal insufficiency, pregnancy, and age restrictions.
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