Antibiotic Tigecycline: Overview and Contraindications
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Questions and Answers

Which bacterial resistance mechanisms does Tigecycline overcome in relation to tetracyclines?

  • RNA transcription and gene expression
  • Efflux pump acquisition and ribosomal protection (correct)
  • Cell wall synthesis and DNA replication
  • Membrane permeability and cell division

    • How does Tigecycline act on bacteria to inhibit protein synthesis?

  • By inhibiting DNA replication
  • By disrupting cell wall synthesis
  • By interfering with RNA transcription
  • By binding to the 30S ribosomal subunit and blocking entry of Aminoacyl-tRNA (correct)

    • Which type of bacteria is Tigecycline effective against?

  • Only Gram-negative bacteria
  • Only Gram-positive bacteria
  • Gram-positive, Gram-negative, and anaerobes (correct)
  • Only Pseudomonas spp.

    • What is the primary reason for not prescribing tetracyclines to children under 8 years of age?

    <p>Risk of permanent discoloration of teeth during tooth development</p> Signup and view all the answers

    What class of antibiotics does Tigecycline belong to?

    <p>Glycylcyclines</p> Signup and view all the answers

    Which antibiotic acts by inhibiting protein synthesis through forming a stable complex with elongation factor EF-G?

    <p>Fusidic acid</p> Signup and view all the answers

    What is the mechanism of action of tetracyclines?

    <p>Reversibly binding to the 30S subunit of the ribosome at the A-site</p> Signup and view all the answers

    Which antibiotic has a broad spectrum that covers atypical bacteria such as Mycoplasma and Chlamydia?

    <p>Doxycycline</p> Signup and view all the answers

    What is a common side effect associated with tetracyclines?

    <p>Photosensitivity</p> Signup and view all the answers

    Which antibiotic is less susceptible to inactivating enzymes due to its chemical structure?

    <p>Amikacin</p> Signup and view all the answers

    Which antibiotic is used topically only and is not active against Pseudomonas aeruginosa?

    <p>Neomycin</p> Signup and view all the answers

    Which antibiotic is effective against MRSA?

    <p>Doxycycline</p> Signup and view all the answers

    Why should patients receiving tetracyclines be kept out of heavy sunlight?

    <p>To prevent photosensitivity reactions</p> Signup and view all the answers

    Which tetracycline is excreted primarily in the intestinal tract?

    <p>Doxycycline</p> Signup and view all the answers

    What is the main reason for the yellow discoloration of teeth associated with tetracycline use?

    <p>Affinity for calcium leading to teeth deposits</p> Signup and view all the answers

    In what body fluids do tetracyclines reach high concentrations?

    <p>Tears and saliva</p> Signup and view all the answers

    Which substance decreases the absorption of tetracyclines?

    <p>Calcium</p> Signup and view all the answers

    What impact do tetracyclines have on normal flora in the body?

    <p>Cause superinfections by modifying normal flora</p> Signup and view all the answers

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