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Questions and Answers
What is the brand name of ticagrelor?
What is the brand name of ticagrelor?
What is the drug class of ticagrelor?
What is the drug class of ticagrelor?
Platelet Aggregation Inhibitor
What are the routes of administration of ticagrelor?
What are the routes of administration of ticagrelor?
60 mg, 90 mg
What are the common indications and dosing of ticagrelor?
What are the common indications and dosing of ticagrelor?
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What is the mechanism of action of ticagrelor?
What is the mechanism of action of ticagrelor?
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Is dose adjustment necessary for ticagrelor in renal impairment?
Is dose adjustment necessary for ticagrelor in renal impairment?
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Are there pharmacogenetics for ticagrelor?
Are there pharmacogenetics for ticagrelor?
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What are the contraindications to ticagrelor?
What are the contraindications to ticagrelor?
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What are the black box warnings for ticagrelor?
What are the black box warnings for ticagrelor?
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What are the drug interactions with ticagrelor?
What are the drug interactions with ticagrelor?
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What are common adverse reactions with ticagrelor?
What are common adverse reactions with ticagrelor?
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What are rare but serious adverse reactions with ticagrelor?
What are rare but serious adverse reactions with ticagrelor?
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What are the efficacy monitoring parameters for ticagrelor?
What are the efficacy monitoring parameters for ticagrelor?
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What are the toxicity monitoring parameters for ticagrelor?
What are the toxicity monitoring parameters for ticagrelor?
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Study Notes
Ticagrelor Overview
- Brand name: Brilinta
- Drug class: Platelet Aggregation Inhibitor
- Available doses: 60 mg, 90 mg
Indications and Dosing
- Indicated for acute coronary syndrome or history of myocardial infarction
- Initial dose: 180 mg orally (po) loading dose
- Maintenance dosing: 90 mg po twice daily (bid) along with aspirin (max 100 mg) for 12 months
- After 12 months, the dose is reduced to 60 mg po bid
Mechanism of Action
- Acts as a reversible and noncompetitive binder to the adenosine diphosphate (ADP) P2Y12 receptor on platelets
- Prevents ADP-mediated activation of the GPIIb/IIIa receptor complex, leading to reduced platelet aggregation
Renal Dose Adjustment
- No dose adjustment required for renal impairment
Pharmacogenetics
- Efficacy remains consistent between CYP2C19 poor metabolizers and extensive metabolizers
Contraindications
- Hypersensitivity to the drug
- Active bleeding conditions
- History of intracranial bleeding
Black Box Warnings
- Associated with increased bleeding risk
- Considerations for use in coronary artery bypass graft (CABG) surgery
- Avoid aspirin doses exceeding 100 mg daily
Drug Interactions
- Potential interactions with anticoagulants and other drugs affecting platelet function
- Interactions with CYP3A4/5 inducers and inhibitors
Adverse Reactions
- Common adverse effect: Dyspnea
- Rare but serious reactions include:
- Angioedema
- Atrioventricular block
- Bradycardia
- Gout
- Hypersensitivity reactions
- Skin rash
Monitoring Parameters
- Efficacy monitoring: Prevention of thrombotic events
- Toxicity monitoring: Signs and symptoms of bleeding, especially when used with anticoagulants
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Description
This quiz consists of flashcards focused on the medication ticagrelor, including its brand name, drug class, routes of administration, and common indications. Test your knowledge and understanding of ticagrelor's key aspects and dosing information.
