Ticagrelor Drug Flashcards

Questions and Answers

What is the brand name of ticagrelor?

Plavix

Aspirin

Brilinta (correct)

Clopidogrel

What is the drug class of ticagrelor?

Platelet Aggregation Inhibitor

What are the routes of administration of ticagrelor?

60 mg, 90 mg

What are the common indications and dosing of ticagrelor?

Acute coronary syndrome or history of myocardial infarction: 180 mg po loading dose, followed by 90 mg po bid (in combination with aspirin, max dose of 100 mg) for 12 mo, then reduce dose to 60 mg po bid Signup and view all the answers

What is the mechanism of action of ticagrelor?

Reversible and noncompetitive binder of the adenosine diphosphate (ADP) P2Y12 receptor on the platelet surface which prevents ADP-mediated activation of the GPIIb/IIIa receptor complex thereby reducing platelet aggregation. Signup and view all the answers

Is dose adjustment necessary for ticagrelor in renal impairment?

False Signup and view all the answers

Are there pharmacogenetics for ticagrelor?

True Signup and view all the answers

What are the contraindications to ticagrelor?

Hypersensitivity, active bleeding, history of intracranial bleeding Signup and view all the answers

What are the black box warnings for ticagrelor?

Bleeding risk; use in CABG surgery, avoid aspirin >100 mg daily Signup and view all the answers

What are the drug interactions with ticagrelor?

Anticoagulants, drugs with antiplatelet effects, CYP3A4/5 inducers and inhibitors Signup and view all the answers

What are common adverse reactions with ticagrelor?

Dyspnea Signup and view all the answers

What are rare but serious adverse reactions with ticagrelor?

Angioedema, atrioventricular block, bradycardia, gout, hypersensitivity reaction, skin rash Signup and view all the answers

What are the efficacy monitoring parameters for ticagrelor?

Prevention of thrombotic events Signup and view all the answers

What are the toxicity monitoring parameters for ticagrelor?

Signs/symptoms of bleeding, especially with concomitant anticoagulant therapy Signup and view all the answers

Study Notes

Ticagrelor Overview

Brand name: Brilinta
Drug class: Platelet Aggregation Inhibitor
Available doses: 60 mg, 90 mg

Indications and Dosing

Indicated for acute coronary syndrome or history of myocardial infarction
Initial dose: 180 mg orally (po) loading dose
Maintenance dosing: 90 mg po twice daily (bid) along with aspirin (max 100 mg) for 12 months
After 12 months, the dose is reduced to 60 mg po bid

Mechanism of Action

Acts as a reversible and noncompetitive binder to the adenosine diphosphate (ADP) P2Y12 receptor on platelets
Prevents ADP-mediated activation of the GPIIb/IIIa receptor complex, leading to reduced platelet aggregation

Renal Dose Adjustment

No dose adjustment required for renal impairment

Pharmacogenetics

Efficacy remains consistent between CYP2C19 poor metabolizers and extensive metabolizers

Contraindications

Hypersensitivity to the drug
Active bleeding conditions
History of intracranial bleeding

Black Box Warnings

Associated with increased bleeding risk
Considerations for use in coronary artery bypass graft (CABG) surgery
Avoid aspirin doses exceeding 100 mg daily

Drug Interactions

Potential interactions with anticoagulants and other drugs affecting platelet function
Interactions with CYP3A4/5 inducers and inhibitors

Adverse Reactions

Common adverse effect: Dyspnea
Rare but serious reactions include:
- Angioedema
- Atrioventricular block
- Bradycardia
- Gout
- Hypersensitivity reactions
- Skin rash

Monitoring Parameters

Efficacy monitoring: Prevention of thrombotic events
Toxicity monitoring: Signs and symptoms of bleeding, especially when used with anticoagulants

Description

This quiz consists of flashcards focused on the medication ticagrelor, including its brand name, drug class, routes of administration, and common indications. Test your knowledge and understanding of ticagrelor's key aspects and dosing information.