TIA and Seizure Management
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Questions and Answers

A patient with a TIA is being evaluated in the emergency department. Which factor, if present, would necessitate hospitalization?

  • ABCD2 score of 5, regardless of timeframe for outpatient diagnostic workup. (correct)
  • Patient reports symptoms resolving within 30 minutes.
  • ABCD2 score of 2, with outpatient diagnostic workup achievable within 48 hours.
  • Patient has a history of well-controlled hypertension.

Following a mild stroke or TIA, what is the MOST appropriate initial antiplatelet strategy to reduce the risk of recurrent events?

  • Aspirin + Dipyridamole (Aggrenox)
  • Clopidogrel alone
  • Aspirin (ASA) alone
  • Short-term Aspirin + Clopidogrel (correct)

When evaluating a patient with a suspected TIA, which imaging modality is MOST sensitive for detecting acute tissue damage to differentiate from stroke mimics?

  • MRI (correct)
  • Non-contrast CT scan
  • Electrocardiogram (ECG)
  • Carotid ultrasound

A patient with a history of paroxysmal atrial fibrillation presents with a TIA. Beyond guideline-directed medical management for modifiable risk factors, what is the MOST appropriate preventative treatment?

<p>Anticoagulation (D)</p> Signup and view all the answers

A patient experiences a first-time, unprovoked motor seizure. After initial assessment and stabilization, which of the following is the MOST appropriate next step in management?

<p>No immediate medication, but further investigation is needed (A)</p> Signup and view all the answers

A patient experiencing a seizure presents with rhythmic movements in their hands and feet. Which lobe is MOST likely involved in this focal seizure?

<p>Occipital lobe (A)</p> Signup and view all the answers

Which of the following is the MOST appropriate initial neuroimaging choice for a patient presenting with a first-time seizure?

<p>MRI with contrast (B)</p> Signup and view all the answers

Which of the following historical details is LEAST relevant when evaluating a patient presenting with a seizure?

<p>History of osteoarthritis (D)</p> Signup and view all the answers

An elderly patient (>60 years old) presents with new-onset seizures. Considering the common etiologies in this age group, which of the following is the MOST likely cause?

<p>Stroke (D)</p> Signup and view all the answers

A patient is observed to have a seizure characterized by lip smacking, chewing movements and unresponsiveness. After the event, they are confused and cannot recall the episode. Which area of the brain is MOST likely involved?

<p>Temporal lobe (D)</p> Signup and view all the answers

A patient experiencing seizures is undergoing diagnostic evaluation. An EEG is performed, but the results are inconclusive. What is the MOST appropriate next step in further classifying the patient's seizures?

<p>Repeat the EEG, possibly with prolonged monitoring (D)</p> Signup and view all the answers

A patient with a known seizure disorder on medication experiences a breakthrough seizure. Besides medication non-compliance, which of the following medications could potentially LOWER the seizure threshold?

<p>Bupropion (D)</p> Signup and view all the answers

A patient is suspected of having a seizure disorder. After initial investigations, a lumbar puncture is considered. In which of the following scenarios is a lumbar puncture MOST warranted?

<p>The patient presents with signs of infection (A)</p> Signup and view all the answers

Which of the following is the most common type of stroke in the United States?

<p>Ischemic stroke due to thrombotic occlusion (B)</p> Signup and view all the answers

A patient presents with sudden onset of right-sided weakness and speech difficulty. Which of the following conditions should be ruled out in the differential diagnosis, besides stroke?

<p>Complicated migraine (A)</p> Signup and view all the answers

Which of the following is the MOST critical action in the initial treatment of an acute ischemic stroke?

<p>Administration of IV thrombolytics within 3 hours of onset (B)</p> Signup and view all the answers

Which of the following is a significant risk factor specifically associated with hemorrhagic stroke?

<p>Cocaine abuse (D)</p> Signup and view all the answers

In managing a patient with a hemorrhagic stroke, which of the following blood pressure ranges is generally targeted using IV medications such as labetalol or nicardipine?

<p>sBP 140-180 mmHg (D)</p> Signup and view all the answers

Which of the following is the MOST common etiology of ischemic stroke?

<p>Vascular disease (B)</p> Signup and view all the answers

What is the primary goal in the treatment of stroke?

<p>Minimizing disability and preventing recurrent stroke (D)</p> Signup and view all the answers

Which of the following is a potential treatment for hemorrhagic stroke?

<p>Ventricular drainage (D)</p> Signup and view all the answers

A patient presents with a witnessed seizure lasting 35 minutes. Which of the following best describes this condition?

<p>Status epilepticus (B)</p> Signup and view all the answers

Which of the following is the MOST likely underlying cause of status epilepticus?

<p>Failure of normal inhibitory pathways (GABA) (D)</p> Signup and view all the answers

A patient with a known seizure disorder is brought to the emergency department in status epilepticus. Which of the following is the MOST appropriate initial treatment?

<p>Intravenous lorazepam (B)</p> Signup and view all the answers

A patient is diagnosed with epilepsy after experiencing two unprovoked seizures. According to the provided information, what is the MINIMUM time interval that must separate these seizures for a diagnosis of epilepsy?

<p>24 hours (B)</p> Signup and view all the answers

An EEG is performed on a patient suspected of having a seizure disorder. Which finding on the EEG would be MOST indicative of abnormal electrical activity in the brain?

<p>Asymmetric waveforms (A)</p> Signup and view all the answers

A patient experiences a single, unprovoked seizure. According to the guidelines, under which circumstance should the physician consider initiating anti-epileptic drug (AED) therapy?

<p>The patient has a high risk of seizure recurrence based on EEG and MRI findings. (C)</p> Signup and view all the answers

A patient has been seizure-free for two years while taking anti-epileptic medication. What is the MOST important factor to consider when contemplating medication withdrawal?

<p>The patient's epileptic syndrome and its likelihood of recurrence (A)</p> Signup and view all the answers

A patient presents with sudden onset of focal neurological deficits that resolve completely within 7 minutes. Brain imaging does not reveal any infarction. Which of the following is the MOST likely diagnosis?

<p>Transient ischemic attack (TIA) (A)</p> Signup and view all the answers

Which of the following is the MOST important next step in managing a patient diagnosed with TIA?

<p>Evaluating for underlying causes and assessing stroke risk (B)</p> Signup and view all the answers

Which component of the ABCD2 score assesses the duration of TIA symptoms?

<p>Episode duration (D)</p> Signup and view all the answers

Which of the following is the MOST crucial piece of information to gather when assessing a patient for a potential stroke?

<p>The time of the patient's last known baseline state. (B)</p> Signup and view all the answers

A patient presents with acute onset of right arm weakness and difficulty speaking. Which of the following best describes this presentation?

<p>Acute onset with maximal focal neurologic deficit. (B)</p> Signup and view all the answers

The NIH Stroke Scale (NIHSS) is primarily used to:

<p>Reliably evaluate stroke severity and predict prognosis. (D)</p> Signup and view all the answers

According to the provided information, what is the interpretation time goal from triage to Non-Contrast Computed Tomography (NCCT) interpretation for a patient with suspected stroke?

<p>Within 45 minutes. (A)</p> Signup and view all the answers

Which of the following NIH Stroke Scale (NIHSS) scores would be MOST indicative of a severe stroke?

<p>18 (D)</p> Signup and view all the answers

After determining a patient is having an ischemic stroke, what is the next immediate step?

<p>Order a STAT NCCT of the brain. (D)</p> Signup and view all the answers

Which antiplatelet regimen is recommended for the secondary prevention of ischemic stroke?

<p>ASA 162-325 mg daily monotherapy. (A)</p> Signup and view all the answers

In a patient who has experienced a stroke due to carotid artery disease, carotid endarterectomy (CEA) is generally considered beneficial when the ipsilateral extracranial internal carotid stenosis is:

<p>50% or greater in patients at lower surgical risk. (E)</p> Signup and view all the answers

A patient presents with a sudden, severe headache described as 'the worst headache of my life,' accompanied by focal neurological deficits. Which of the following is the MOST likely underlying cause, based on the information provided?

<p>Cerebral Aneurysm Rupture (B)</p> Signup and view all the answers

A young female patient with a family history of polycystic kidney disease and a history of smoking presents with a suspected cerebral aneurysm rupture. Which of these factors contributes MOST significantly to the ETIOLOGY of her condition?

<p>Smoking and family history (D)</p> Signup and view all the answers

During the management of a patient with a ruptured cerebral aneurysm, what is the MOST important, initial blood pressure target to maintain, and why?

<p>sBP &lt; 130 mmHg to reduce the risk of re-bleeding (D)</p> Signup and view all the answers

A patient diagnosed with a subarachnoid hemorrhage (SAH) develops hydrocephalus. What intervention is MOST appropriate to manage this complication?

<p>Inserting an intraventricular catheter to drain excess cerebrospinal fluid (D)</p> Signup and view all the answers

Which of the following medications is MOST specifically indicated to prevent vasospasm and improve outcomes in patients following a subarachnoid hemorrhage (SAH)?

<p>Nimodipine (D)</p> Signup and view all the answers

A patient experiences a transient loss of consciousness. Which of the following findings would STRONGLY suggest syncope rather than a seizure?

<p>A clear trigger such as prolonged standing or emotional stress. (C)</p> Signup and view all the answers

Which of the following statements BEST describes the underlying pathophysiology of syncope?

<p>Excessive vagal tone or impaired control of peripheral circulation (C)</p> Signup and view all the answers

An arteriovenous malformation (AVM) is characterized by which of the following?

<p>Abnormal connection between arteries and veins without intervening capillaries (B)</p> Signup and view all the answers

A patient is diagnosed with an arteriovenous malformation (AVM) in the brain and is being considered for treatment. Which of the following is a treatment modality for AVMs?

<p>Embolization (C)</p> Signup and view all the answers

How does the pathophysiology of an arteriovenous malformation (AVM) DIFFER from that of a cerebral aneurysm?

<p>AVMs are characterized by abnormal connections between arteries and veins, while aneurysms involve focal outpouchings of arterial walls. (C)</p> Signup and view all the answers

Flashcards

Seizure

A transient occurrence of signs or symptoms due to abnormal, excessive, or synchronous neuronal activity in the brain.

Seizure Etiologies

Idiopathic (62%), Stroke (15%), Brain tumor (6%), Head trauma, Intracranial infection, Cerebral degeneration, Congenital brain malformations, Inborn errors of metabolism.

Seizure: Initial Evaluation

Complete H&P, including witnessed description of event, substance abuse, head trauma, cerebrovascular event, cardiac history, sleep d/o, medications (e.g., tramadol, bupropion)

First Seizure Workup

Electrolytes (CMP), Glucose, HCG, ECG, EEG. Neuroimaging (MRI + contrast preferred for first seizure).

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Seizure: EEG Importance

EEG is essential for diagnosis and classification.

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Seizure: Neuroimaging Preference

MRI is preferred over CT for identifying structural lesions.

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Focal Seizures

Symptoms depend on the lobe involved. Sudden onset (e.g., rhythmic movements, hallucinations).

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Temporal Lobe Seizure

Bland, quiet, sense of fear, lip smacking/chewing, unresponsive, fatigue or confusion, may not remember the episode.

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TIA Hospitalization Criteria

Hospitalize TIA patients if presenting within 72 hours AND ABCD2 score ≥4, OR score 0-3 with uncertain outpatient workup completion within 2 days.

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Medication for Stroke/TIA Risk Reduction

Short-term dual antiplatelet therapy (DAPT) with ASA + Clopidogrel is best to reduce recurrent stroke risk after mild stroke or TIA.

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TIA Urgent Evaluation

Non-contrast CT (to rule out bleed), MRI (to determine tissue damage), Neurovascular imaging (carotid artery disease) and Cardiovascular evaluation (ECG, Event monitor, Echo)

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TIA Routine Management

HTN, Dyslipidemia, DM, Smoking/lifestyle modifications, Antiplatelet (ASA + clopidogrel), and Anticoagulation when appropriate.

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Stroke (CVA) Definition

Sudden onset of neurologic deficits from a cerebrovascular origin.

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Status Epilepticus

A continuous seizure lasting longer than 30 minutes, or a series of seizures without regaining consciousness.

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Epilepsy

Chronic condition with at least two unprovoked seizures occurring more than 24 hours apart.

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EEG

Visual representation of brain's electrical activity. Used to diagnose seizures.

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Provoked Seizure

Seizures triggered by a specific, identifiable cause (e.g., fever, drug abuse, brain tumor).

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Seizure treatment duration

Seizure treatments, where patients should be seizure free for ~2 years on Rx prior to medication withdrawal.

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Starting Anti-Epileptic Drugs

Starting Anti-Epileptic Drugs (AEDs) may not be needed. Only treat if high risk recurrence (EEG and or MRI +).

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High Risk of Seizure Recurrence

Risk factor Status epilepticus, History of TBI, Brain lesion on neuroimaging.

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Transient Ischemic Attack (TIA)

Temporary neurologic dysfunction due to brief interruption of blood supply, without lasting brain damage.

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Etiology of TIA

Vascular disease, embolization (a fib, endocarditis,) hematologic (clotting disorders, Sickle cell, polycythemia)

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TIA - RED FLAGS for future STROKE

Age > 60, Diabetes, Speech or motor difficulties, Episode duration.

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Stroke

Blockage or rupture of blood vessels in the brain, leading to cell damage.

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Ischemic Stroke

87% of strokes are caused by a blocked artery in the brain

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Hemorrhagic Stroke

Stroke caused by bleeding in the brain, often due to HTN or AVMs

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Stroke Risk Factors

High blood pressure, diabetes, smoking, atrial fibrillation.

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Stroke Treatment Goals

Minimize disability and prevent recurrence

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tPA (Alteplase)

Administered within 3 hours of ischemic stroke onset to dissolve clots.

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Hemorrhagic Stroke BP Control

IV labetalol or nicardipine to maintain sBP between 140-180 mmHg

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Most Common Emboli Source?

The heart is the most common site of origin for emboli that cause stroke.

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Stroke Symptoms

Weakness on one side of the body and difficulty speaking are common signs.

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Stroke Diagnosis: History & Exam

Focuses on symptoms indicating focal neurologic injury to identify affected areas of the brain.

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NIH Stroke Scale (NIHSS)

A standardized 15-item assessment that quantifies neurological deficits after a stroke.

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NIHSS Severity Levels

Mild strokes typically score 8 or less, moderate scores range from 9-15 and severe strokes are 16 or greater.

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Ischemic Stroke Initial Steps

Determine symptom onset, NIHSS score, labs (glucose, CBC, coag), and STAT NCCT brain within 45 minutes.

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STAT NCCT Brain Scan

Distinguishes between ischemic and hemorrhagic stroke. Crucial before administering rtPA.

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rtPA

A fibrinolytic agent used to dissolve blood clots and restore blood flow in ischemic stroke.

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Carotid Endarterectomy (CEA)

A surgical procedure to remove plaque buildup from the carotid artery to prevent future strokes.

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Arteriovenous Malformation (AVM)

Congenital vascular malformations with abnormal arteriovenous communication, lacking intervening capillaries. Can vary greatly in size.

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Cerebral Aneurysm Rupture

A focal distortion of a blood vessel wall, often at arterial branch points in the Circle of Willis. Can lead to rupture and hemorrhage.

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Symptoms of Cerebral Aneurysm Rupture

Severe headache, focal neurologic deficits, possible coma or death. Often due to rupture of a cerebral aneurysm.

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Treatment for Cerebral Aneurysm Rupture

ABCs, emergent brain imaging, neurosurgery consult (clip or coil). Strict BP control, seizure prophylaxis, Nimodipine.

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Intracranial Hemorrhage

Hemorrhage within the brain tissue or subarachnoid space. Presents with sudden, severe headache and neurological symptoms.

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Intracranial Hemorrhage Treatment

Prevent rebleeding (neurosurgery), control BP, monitor ICP, manage pain. Be alert for hydrocephalus.

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Syncope

A transient loss of consciousness due to excessive vagal tone or impaired peripheral circulation control lasting only seconds.

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Syncope risk factors

Heart disease, age >60, stress.

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Syncope DDx

Seizure, hypoglycemia.

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Syncope treatment

Counterpressure maneuvers (Valsalva), treat underlying cause.

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