8 Questions
Why is levothyroxine preferred over liothyronine?
It has a long half-life and stable drug levels
What is the role of thioamides in treating hyperactive thyroid?
Blocking thyroid peroxidase
What is a potential side effect of methimazole used in hyperthyroidism treatment?
Aplastic anemia
Why is PTU preferred over methimazole for some patients with hyperactive thyroid?
It blocks 5 diiodinase in addition to thyroid peroxidase
What is the primary goal of propranolol in treating thyroid storm?
To block sympathetic overdrive
Why are high iodine doses used to treat conditions like Graves disease?
To suppress hormone synthesis
In thyroid storm treatment, what is the purpose of adding hydrocortisone to the therapy?
To inhibit T3 conversion
Which treatment option helps eliminate circulating hormones in thyroid storm?
(plasmapheresis)
Study Notes
- Thyroid function involves TSH and thyroid replacement medications like levothyroxine and liothyronine.
- Levothyroxine is preferred over liothyronine due to its long half-life and stability in drug levels.
- Levothyroxine dosing varies for pregnant patients, those on oral contraceptives, hepatic failure patients, the elderly, and those with heart disease.
- Thyroid hormone replacement is used for hypothyroidism and myxedema coma.
- Medications for hyperactive thyroid (Graves disease, thyroid storm) include thioamides (methimazole, PTU) and iodine.
- Thioamides block thyroid peroxidase, with PTU also blocking 5 diiodinase, crucial in hyperthyroidism treatment.
- Methimazole can cause aplastic anemia and teratogenic effects, while PTU can lead to severe hepatic toxicity.
- Radioactive iodine and high iodine doses are used to treat hyperactive thyroid conditions like Graves disease.
- Treatment for thyroid storm involves propranolol to block sympathetic overdrive, thioamides to inhibit hormone synthesis, and iodine to block hormone release.
- Hydrocortisone, propranolol, and PTU can be used to block the conversion of T4 to T3 in thyroid storm treatment.
- Additional treatments for thyroid storm include plasmapheresis, cholestyramine to eliminate circulating hormones, and addressing the underlying cause through surgery or radioactive iodine.
Test your knowledge on thyroid function, hormone replacement medications like levothyroxine and liothyronine, and treatments for hypothyroidism and hyperthyroidism including thyroid storm. Learn about dosing variations, side effects, and treatment options for different thyroid conditions.
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