Podcast
Questions and Answers
What is the initial step in the synthesis of thyroid hormones?
What is the initial step in the synthesis of thyroid hormones?
- Endocytosis of thyroglobulin colloid
- Oxidation of iodide
- Trapping of iodide (correct)
- Formation of DIT and MIT
Which enzyme is responsible for the oxidation of iodide to iodine in the synthesis of thyroid hormones?
Which enzyme is responsible for the oxidation of iodide to iodine in the synthesis of thyroid hormones?
- Golgi apparatus enzyme
- Lysosomal enzyme
- Peroxidase enzyme (correct)
- Thyroglobulin enzyme
What is the active form of iodine that combines with tyrosine in the colloid during thyroid hormone synthesis?
What is the active form of iodine that combines with tyrosine in the colloid during thyroid hormone synthesis?
- T4
- MIT
- T3
- DIT (correct)
Where do the synthesized thyroid hormones diffuse into after being cleaved from thyroglobulin colloid?
Where do the synthesized thyroid hormones diffuse into after being cleaved from thyroglobulin colloid?
What is the function of lysosomal enzymes in the synthesis of thyroid hormones?
What is the function of lysosomal enzymes in the synthesis of thyroid hormones?
Which enzyme is responsible for de-iodinating the iodine released from uncoupled mono and di-iodotyrosine in the thyroid?
Which enzyme is responsible for de-iodinating the iodine released from uncoupled mono and di-iodotyrosine in the thyroid?
What is the main fraction of T3 and T4 bound to in the blood?
What is the main fraction of T3 and T4 bound to in the blood?
What class of antithyroid drugs inhibits the peripheral conversion of T4 to T3?
What class of antithyroid drugs inhibits the peripheral conversion of T4 to T3?
Which researchers proposed the 'Wolff-Chaikoff effect' related to the alteration of thyroid hormone levels by large doses of iodine?
Which researchers proposed the 'Wolff-Chaikoff effect' related to the alteration of thyroid hormone levels by large doses of iodine?
What is considered as the most useful biochemical test in thyroid investigations according to the provided text?
What is considered as the most useful biochemical test in thyroid investigations according to the provided text?
