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Thyroid Diseases Diagnosis and Management

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Thyroid Diseases Diagnosis and Management

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Questions and Answers

What is the initial step in the synthesis of thyroid hormones?

Endocytosis of thyroglobulin colloid

Oxidation of iodide

Trapping of iodide (correct)

Formation of DIT and MIT

Which enzyme is responsible for the oxidation of iodide to iodine in the synthesis of thyroid hormones?

Golgi apparatus enzyme

Lysosomal enzyme

Peroxidase enzyme (correct)

Thyroglobulin enzyme

What is the active form of iodine that combines with tyrosine in the colloid during thyroid hormone synthesis?

MIT

DIT (correct)

Where do the synthesized thyroid hormones diffuse into after being cleaved from thyroglobulin colloid?

Bloodstream Signup and view all the answers

What is the function of lysosomal enzymes in the synthesis of thyroid hormones?

Cleaving T3 and T4 from thyroglobulin colloid Signup and view all the answers

Which enzyme is responsible for de-iodinating the iodine released from uncoupled mono and di-iodotyrosine in the thyroid?

Dehalogenase Signup and view all the answers

What is the main fraction of T3 and T4 bound to in the blood?

Plasma proteins Signup and view all the answers

What class of antithyroid drugs inhibits the peripheral conversion of T4 to T3?

Thioamide Signup and view all the answers

Which researchers proposed the 'Wolff-Chaikoff effect' related to the alteration of thyroid hormone levels by large doses of iodine?

Dr. Jan Wolff and Israel Lyon Chaikoff Signup and view all the answers

What is considered as the most useful biochemical test in thyroid investigations according to the provided text?

Serum TSH level Signup and view all the answers