10 Questions
From where do T cell progenitors first arise?
Pluripotent hematopoietic stem cells in the bone marrow
What gives rise to lymphocytes like B cells and T cells?
Common lymphoid progenitor cells
What happens if a nude mouse is congenitally athymic?
It is unable to stimulate antibody production
What happens to patients with complete DiGeorge syndrome?
They fail to make T lymphocytes due to the absence of a thymus
What is normal T cell development dependent upon?
Direct contact with thymic stroma and interaction with secreted molecules
Which polypeptide influences the phenotypic maturation of progenitor cells from the bone marrow and the modulation of the functions of mature T cells?
Thymosin-α
Where do T cell progenitors enter the thymus?
Corticomedullary junction
What is the critical step in T cell development in terms of the acquisition of a specific molecule?
TCR
What are thymocytes referred to at the stage when they lack expression of the CD4 and CD8 co-receptor molecules?
Double-negative (DN) thymocytes
Which gene is only expressed by thymocytes during the rearrangement of the T cell receptor genes in the thymus?
RAG-1
Test your knowledge on the development of T cells from pluripotent hematopoietic stem cells to mature functional T cells in the thymus. This quiz covers the differentiation process and the development of T cell progenitors from common lymphoid progenitor cells.
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