Thymocyte Differentiation and Maturation in T Cells
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Questions and Answers

From where do T cell progenitors first arise?

  • Red marrow of flat bones
  • Lymphoid progenitor cells in the thymus
  • Pluripotent hematopoietic stem cells in the bone marrow (correct)
  • Epiphyseal ends of long bones
  • What gives rise to lymphocytes like B cells and T cells?

  • Bone marrow vasculature
  • Hematopoietic stem cells
  • Thymic stroma
  • Common lymphoid progenitor cells (correct)
  • What happens if a nude mouse is congenitally athymic?

  • It remains highly resistant to infections
  • It can reject xenografts
  • It can mount delayed-type reactions
  • It is unable to stimulate antibody production (correct)
  • What happens to patients with complete DiGeorge syndrome?

    <p>They fail to make T lymphocytes due to the absence of a thymus</p> Signup and view all the answers

    What is normal T cell development dependent upon?

    <p>Direct contact with thymic stroma and interaction with secreted molecules</p> Signup and view all the answers

    Which polypeptide influences the phenotypic maturation of progenitor cells from the bone marrow and the modulation of the functions of mature T cells?

    <p>Thymosin-α</p> Signup and view all the answers

    Where do T cell progenitors enter the thymus?

    <p>Corticomedullary junction</p> Signup and view all the answers

    What is the critical step in T cell development in terms of the acquisition of a specific molecule?

    <p>TCR</p> Signup and view all the answers

    What are thymocytes referred to at the stage when they lack expression of the CD4 and CD8 co-receptor molecules?

    <p>Double-negative (DN) thymocytes</p> Signup and view all the answers

    Which gene is only expressed by thymocytes during the rearrangement of the T cell receptor genes in the thymus?

    <p>RAG-1</p> Signup and view all the answers

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