Podcast
Questions and Answers
From where do T cell progenitors first arise?
From where do T cell progenitors first arise?
- Red marrow of flat bones
- Lymphoid progenitor cells in the thymus
- Pluripotent hematopoietic stem cells in the bone marrow (correct)
- Epiphyseal ends of long bones
What gives rise to lymphocytes like B cells and T cells?
What gives rise to lymphocytes like B cells and T cells?
- Bone marrow vasculature
- Hematopoietic stem cells
- Thymic stroma
- Common lymphoid progenitor cells (correct)
What happens if a nude mouse is congenitally athymic?
What happens if a nude mouse is congenitally athymic?
- It remains highly resistant to infections
- It can reject xenografts
- It can mount delayed-type reactions
- It is unable to stimulate antibody production (correct)
What happens to patients with complete DiGeorge syndrome?
What happens to patients with complete DiGeorge syndrome?
What is normal T cell development dependent upon?
What is normal T cell development dependent upon?
Which polypeptide influences the phenotypic maturation of progenitor cells from the bone marrow and the modulation of the functions of mature T cells?
Which polypeptide influences the phenotypic maturation of progenitor cells from the bone marrow and the modulation of the functions of mature T cells?
Where do T cell progenitors enter the thymus?
Where do T cell progenitors enter the thymus?
What is the critical step in T cell development in terms of the acquisition of a specific molecule?
What is the critical step in T cell development in terms of the acquisition of a specific molecule?
What are thymocytes referred to at the stage when they lack expression of the CD4 and CD8 co-receptor molecules?
What are thymocytes referred to at the stage when they lack expression of the CD4 and CD8 co-receptor molecules?
Which gene is only expressed by thymocytes during the rearrangement of the T cell receptor genes in the thymus?
Which gene is only expressed by thymocytes during the rearrangement of the T cell receptor genes in the thymus?
