Thrombocytopenia

Primary hemostasis and secondary hemostasis

Vasoconstriction; formation of platelet plug; and formation of fibrin clot

Smooth muscle cells of endothelium

<p>Exposure of subendothelial collagen</p> Signup and view all the answers

<p>Protein clotting factors</p> Signup and view all the answers

<p>150,000 to 350,000 platelets/microL</p> Signup and view all the answers

<p>A wound is defined as an acute injury to intact skin.</p> Signup and view all the answers

<p>When a wound occurs, it leaves an actual physical gap in the epidermis that immediately fills with blood, causing a leak.</p> Signup and view all the answers

<p>Blood contains platelets to form a plug and clotting factors to change that plug into a fibrin mesh.</p> Signup and view all the answers

<p>The endothelium of the small blood vessels within the wound clamp down to stem the flow of blood, causing fluid stasis.</p> Signup and view all the answers

<p>If any part of the wound healing process breaks down, an acute wound can become a chronic one.</p> Signup and view all the answers

<p>The five stages of wound healing are hemostasis, inflammation, epithelialization, fibroplasia, and maturation.</p> Signup and view all the answers

<p>Aspirin irreversibly blocks COX via acetylation, stopping TXA2 production and thus platelet aggregation.</p> Signup and view all the answers

<p>Agranulocytosis and seizures.</p> Signup and view all the answers

<p>Abciximab, eptifibatide, tirofiban.</p> Signup and view all the answers

<p>Inhibition of thromboxane A2 or prostaglandin E2.</p> Signup and view all the answers

<p>Ibuprofen, naproxen, indomethacin, diclofenac.</p> Signup and view all the answers

<p>Factor IX concentrate.</p> Signup and view all the answers

<p>Ca2+ is needed by clotting factors to create fibrin clot.</p> Signup and view all the answers

<p>The GpIIb/IIIa receptor binds circulating coagulation protein fibrinogen, allowing platelets to aggregate.</p> Signup and view all the answers

<p>Defective GpIIb/IIIa receptors cause Glanzmann thrombasthenia, which is characterized by prolonged bleeding time and impaired platelet aggregation.</p> Signup and view all the answers

<p>Von Willebrand factor anchors platelets to endothelium and acts as a carrier for factor VIII.</p> Signup and view all the answers

<p>Von Willebrand disease is the most common inherited bleeding disorder.</p> Signup and view all the answers

<p>TTP is treated with plasmapheresis to remove antibodies against ADAMTS13, the enzyme responsible for breaking down von Willebrand factor.</p> Signup and view all the answers

<p>Platelet consumption can be caused by disseminated intravascular coagulation, thrombocytopenic purpura, and hemolytic uremic syndrome.</p> Signup and view all the answers

<p>Thrombocytopenia due to autoimmune reaction is also known as immune thrombocytopenia (ITP) and can be triggered by infection or occur on its own. It should not be confused with thrombotic thrombocytopenic purpura (TTP).</p> Signup and view all the answers

<p>Infections can cause thrombocytopenia through bone marrow suppression, hypersplenism, or platelet consumption. Common infections include Parvovirus B-19, Hepatitis C, and Hepatitis E.</p> Signup and view all the answers

<p>Medications that can cause thrombocytopenia include AZT, Vinblastine, Chloramphenicol, and Heparin. Heparin-induced thrombocytopenia (HIT) is an autoimmune reaction that occurs in about 5% of individuals who take heparin.</p> Signup and view all the answers

<p>The three steps involved in the formation of a platelet plug are platelet adhesion to the injured vessel, platelet degranulation, and platelet aggregation.</p> Signup and view all the answers

<p>Von Willebrand factor binds to collagen and the glycoprotein receptor GpIb on platelets, facilitating platelet adhesion to the injured vessel.</p> Signup and view all the answers