Thrombocytopenia

Primary hemostasis and secondary hemostasis

Vasoconstriction; formation of platelet plug; and formation of fibrin clot

To stop blood loss

<p>To create a temporary plug</p> Signup and view all the answers

<p>To create a stable clot</p> Signup and view all the answers

<p>150,000 to 350,000 platelets/microL</p> Signup and view all the answers

<p>A wound is an acute injury to intact skin.</p> Signup and view all the answers

<p>A physical gap in the epidermis is formed and it immediately fills with blood.</p> Signup and view all the answers

<p>The blood in a wound contains platelets to form a plug and clotting factors to change the plug into a fibrin mesh.</p> Signup and view all the answers

<p>The endothelium of small blood vessels clamp down to stem the flow of blood and cause fluid stasis.</p> Signup and view all the answers

<p>The five stages of wound healing are hemostasis, inflammation, epithelialization, fibroplasia, and maturation.</p> Signup and view all the answers

<p>If a wound becomes chronic, it becomes arrested in one of the five stages of wound healing and cannot progress further.</p> Signup and view all the answers

<p>Ca2+ is needed by clotting factors to create fibrin clot.</p> Signup and view all the answers

<p>The receptor GpIIb/IIIa binds circulating coagulation protein fibrinogen.</p> Signup and view all the answers

<p>A defective GpIIb/IIIa causes Glanzmann thrombasthenia.</p> Signup and view all the answers

<p>Fibrinogen binding to GpIIb/IIIa receptors on two different platelets links them together and forms a platelet plug.</p> Signup and view all the answers

<p>Bernard-Soulier Syndrome is caused by a defective glycoprotein GpIb receptor on platelets.</p> Signup and view all the answers

<p>The most common inherited bleeding disorder is Von Willebrand disease.</p> Signup and view all the answers

<p>Aspirin irreversibly blocks COX via acetylation, stopping TXA2 production and thus platelet aggregation.</p> Signup and view all the answers

<p>Aspirin</p> Signup and view all the answers

<p>Abciximab, eptifibatide, tirofiban</p> Signup and view all the answers

<p>Ibuprofen, naproxen, indomethacin, diclofenac</p> Signup and view all the answers

<p>DDAVP</p> Signup and view all the answers

<p>Argatroban, Lepirudin, Bivalirudin, Dabigatran</p> Signup and view all the answers

<p>Thrombocytopenia due to platelet consumption can be caused by disseminated intravascular coagulation, thrombocytopenic purpura, and hemolytic uremic syndrome.</p> Signup and view all the answers

<p>The current preferred name for thrombocytopenia due to autoimmune reaction is immune thrombocytopenia (ITP).</p> Signup and view all the answers

<p>In thrombotic thrombocytopenic purpura, ADAMTS13, a protease that cleaves von Willebrand factor, is impeded.</p> Signup and view all the answers

<p>Infections can cause thrombocytopenia via bone marrow suppression, hypersplenism, or platelet consumption.</p> Signup and view all the answers

<p>AZT, Vinblastine, Chloramphenicol, and Benzene are drugs that can cause thrombocytopenia.</p> Signup and view all the answers

<p>Heparin-induced thrombocytopenia (HIT) is an autoimmune reaction that occurs in about 5% of individuals who take heparin.</p> Signup and view all the answers