30 Questions
What are the two phases of hemostasis?
Primary hemostasis and secondary hemostasis
What are the three steps of hemostasis?
Vasoconstriction; formation of platelet plug; and formation of fibrin clot
What is the main job of vasoconstriction?
To stop blood loss
What is the main job of platelet plug formation?
To create a temporary plug
What is the main job of fibrin clot formation?
To create a stable clot
What is the normal platelet count?
150,000 to 350,000 platelets/microL
What is a wound?
A wound is an acute injury to intact skin.
What happens immediately after a breach in the skin?
A physical gap in the epidermis is formed and it immediately fills with blood.
What does the blood in a wound contain?
The blood in a wound contains platelets to form a plug and clotting factors to change the plug into a fibrin mesh.
What role does the endothelium of small blood vessels play in wound healing?
The endothelium of small blood vessels clamp down to stem the flow of blood and cause fluid stasis.
What are the five stages of wound healing?
The five stages of wound healing are hemostasis, inflammation, epithelialization, fibroplasia, and maturation.
What happens if a wound becomes chronic?
If a wound becomes chronic, it becomes arrested in one of the five stages of wound healing and cannot progress further.
What is the role of Ca2+ in the clotting process?
Ca2+ is needed by clotting factors to create fibrin clot.
What is the function of the receptor GpIIb/IIIa?
The receptor GpIIb/IIIa binds circulating coagulation protein fibrinogen.
What happens when there is a defective GpIIb/IIIa?
A defective GpIIb/IIIa causes Glanzmann thrombasthenia.
What is the result of fibrinogen binding to GpIIb/IIIa receptors on two different platelets?
Fibrinogen binding to GpIIb/IIIa receptors on two different platelets links them together and forms a platelet plug.
What is the cause of Bernard-Soulier Syndrome?
Bernard-Soulier Syndrome is caused by a defective glycoprotein GpIb receptor on platelets.
What is the most common inherited bleeding disorder?
The most common inherited bleeding disorder is Von Willebrand disease.
What is the mechanism of action of aspirin as a blood thinner?
Aspirin irreversibly blocks COX via acetylation, stopping TXA2 production and thus platelet aggregation.
What are the names of the COX inhibitors mentioned in the text?
Aspirin
What are the names of the Glycoprotein GpIIb/IIIa Receptor Inhibitors mentioned in the text?
Abciximab, eptifibatide, tirofiban
What are the names of the Reversible Prostaglandin E2 Inhibitors mentioned in the text?
Ibuprofen, naproxen, indomethacin, diclofenac
What is the treatment for mild bleeding in Hemophilia A?
DDAVP
What are the names of the Direct Thrombin inhibitors mentioned in the text?
Argatroban, Lepirudin, Bivalirudin, Dabigatran
What are the causes of thrombocytopenia due to platelet consumption?
Thrombocytopenia due to platelet consumption can be caused by disseminated intravascular coagulation, thrombocytopenic purpura, and hemolytic uremic syndrome.
What is the current preferred name for thrombocytopenia due to autoimmune reaction?
The current preferred name for thrombocytopenia due to autoimmune reaction is immune thrombocytopenia (ITP).
What is the role of ADAMTS13 in thrombotic thrombocytopenic purpura?
In thrombotic thrombocytopenic purpura, ADAMTS13, a protease that cleaves von Willebrand factor, is impeded.
How can infections cause thrombocytopenia?
Infections can cause thrombocytopenia via bone marrow suppression, hypersplenism, or platelet consumption.
What drugs can cause thrombocytopenia?
AZT, Vinblastine, Chloramphenicol, and Benzene are drugs that can cause thrombocytopenia.
What is Heparin-induced thrombocytopenia (HIT)?
Heparin-induced thrombocytopenia (HIT) is an autoimmune reaction that occurs in about 5% of individuals who take heparin.
Test your knowledge on Thrombocytopenia: Causes, Symptoms, and Treatment. Learn about platelet consumption, autoimmune reactions, infections, medications, and congenital platelet disorders that can lead to low platelet count. Explore thrombotic microangiopathy and the role of endothelium injury in clot formation. Find out more about the diagnosis and management of this condition.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
