Therapeutics in Endodontics Prof. Maged Negm Quiz
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Questions and Answers

Which mechanism of action of antibiotics involves the suppression of bacterial protein synthesis?

  • Inhibition of cell wall formation
  • Direct toxicity
  • Biologic and metabolic alteration in the host
  • Induction of autolysis (correct)
  • What step is recommended in the prophylactic use of antibiotics to be carried out prior to a medical procedure?

  • Diagnose the type of microorganism
  • Select the proper dose
  • Extend duration of drug administration to the proper period
  • Begin antibiotic administration 1 to 2 hours prior to the procedure (correct)
  • Which antibiotic agent is known to be highly antigenic (allergenic)?

  • Tetracyclines
  • Cephalosporins
  • Erythromycin
  • Penicillins (correct)
  • Which antibiotic is associated with direct toxicity and extremely low allergenic effects?

    <p>Erythromycin</p> Signup and view all the answers

    Which antibiotic shows direct toxicity leading to liver damage and tooth discoloration?

    <p>Tetracyclines</p> Signup and view all the answers

    "When orally administered, 2/3rds or 3/4th of this antibiotic are destroyed in the stomach." Which antibiotic does this statement refer to?

    <p>Penicillin G</p> Signup and view all the answers

    Which type of allergic reaction to penicillin is characterized by urticaria and anaphylactic shock?

    <p>Immediate (within 20 minutes)</p> Signup and view all the answers

    What percentage of Penicillin V is absorbed when taken orally?

    <p>Approximately 65%</p> Signup and view all the answers

    Which enzyme is effective against B-lactamase and is a component of Augmentin?

    <p>Clavulanic acid</p> Signup and view all the answers

    Which of the following penicillins is semi-synthetic and stable against gastric acid?

    <p>Penicillin V</p> Signup and view all the answers

    What type of organisms are more sensitive to Cephalosporins among Gram-positive and Gram-negative bacteria?

    <p>Gram-positive</p> Signup and view all the answers

    Which antibiotic is safe in case of impaired renal function due to being detoxified in the liver?

    <p>Erythromycin</p> Signup and view all the answers

    What is the drug of choice for orofacial infections caused by both aerobes and anaerobes?

    <p>Penicillin G</p> Signup and view all the answers

    What is the primary route of administration for Clindamycin and Lincomycin?

    <p>Oral</p> Signup and view all the answers

    Which antibiotic is characterized by a large macrolide ring and destroyed by gastric acid, necessitating an enteric coating?

    <p>Erythromycin</p> Signup and view all the answers

    What adverse effect is extremely rare with Erythromycin?

    <p>Allergy</p> Signup and view all the answers

    Which antibiotic has a greater effect against anaerobes compared to Erythromycin?

    <p>Clindamycin</p> Signup and view all the answers

    What is the pharmacologic effect of Diazepam (Valium) according to the text?

    <p>Antianxiety</p> Signup and view all the answers

    Which antibiotic exhibits cross-allergy with penicillin due to being chemically closely related to Cephalosporins?

    <p>Cefotaxime</p> Signup and view all the answers

    Which of the following is NOT an adverse effect of Diazepam (Valium) as mentioned in the text?

    <p>Hypertension</p> Signup and view all the answers

    Which of the following conditions is a contraindication for using Barbiturates based on the text?

    <p>Glaucoma</p> Signup and view all the answers

    What is the adult oral dose range for Diazepam (Valium) based on the text?

    <p>2-10 mg</p> Signup and view all the answers

    What is one of the differences between Barbiturates and Non-Barbiturates based on the text?

    <p>Cross-allergenicity</p> Signup and view all the answers

    Which drug from the provided list is classified as a Non-Barbiturate and has sedative-hypnotic properties?

    <p>Methohexital (Brevital)</p> Signup and view all the answers

    Which of the following tetracyclines is associated with major adverse effect pseudomembranous colitis?

    <p>Doxycycline (Vibramycin)</p> Signup and view all the answers

    What is the spectrum of tetracyclines in terms of bacteria they are effective against?

    <p>Bacteriostatic to gram-positive and gram-negative bacteria</p> Signup and view all the answers

    What is a common adverse effect of tetracyclines related to the developing dentition?

    <p>Staining of teeth</p> Signup and view all the answers

    Which route of administration is recommended for metronidazole (Flagyl) to be effective against obligate anaerobic microorganisms?

    <p>Rectal administration</p> Signup and view all the answers

    What is one of the significant contraindications for using tetracyclines?

    <p>Liver damage</p> Signup and view all the answers

    Which tetracycline has the highest allergenic potential among the options provided?

    <p>Minocycline (Minocin, Vectrin)</p> Signup and view all the answers

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