Therapeutics in Endodontics Prof. Maged Negm Quiz
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Questions and Answers

Which mechanism of action of antibiotics involves the suppression of bacterial protein synthesis?

  • Inhibition of cell wall formation
  • Direct toxicity
  • Biologic and metabolic alteration in the host
  • Induction of autolysis (correct)

What step is recommended in the prophylactic use of antibiotics to be carried out prior to a medical procedure?

  • Diagnose the type of microorganism
  • Select the proper dose
  • Extend duration of drug administration to the proper period
  • Begin antibiotic administration 1 to 2 hours prior to the procedure (correct)

Which antibiotic agent is known to be highly antigenic (allergenic)?

  • Tetracyclines
  • Cephalosporins
  • Erythromycin
  • Penicillins (correct)

Which antibiotic is associated with direct toxicity and extremely low allergenic effects?

<p>Erythromycin (A)</p> Signup and view all the answers

Which antibiotic shows direct toxicity leading to liver damage and tooth discoloration?

<p>Tetracyclines (B)</p> Signup and view all the answers

"When orally administered, 2/3rds or 3/4th of this antibiotic are destroyed in the stomach." Which antibiotic does this statement refer to?

<p>Penicillin G (C)</p> Signup and view all the answers

Which type of allergic reaction to penicillin is characterized by urticaria and anaphylactic shock?

<p>Immediate (within 20 minutes) (C)</p> Signup and view all the answers

What percentage of Penicillin V is absorbed when taken orally?

<p>Approximately 65% (B)</p> Signup and view all the answers

Which enzyme is effective against B-lactamase and is a component of Augmentin?

<p>Clavulanic acid (C)</p> Signup and view all the answers

Which of the following penicillins is semi-synthetic and stable against gastric acid?

<p>Penicillin V (A)</p> Signup and view all the answers

What type of organisms are more sensitive to Cephalosporins among Gram-positive and Gram-negative bacteria?

<p>Gram-positive (D)</p> Signup and view all the answers

Which antibiotic is safe in case of impaired renal function due to being detoxified in the liver?

<p>Erythromycin (D)</p> Signup and view all the answers

What is the drug of choice for orofacial infections caused by both aerobes and anaerobes?

<p>Penicillin G (A)</p> Signup and view all the answers

What is the primary route of administration for Clindamycin and Lincomycin?

<p>Oral (D)</p> Signup and view all the answers

Which antibiotic is characterized by a large macrolide ring and destroyed by gastric acid, necessitating an enteric coating?

<p>Erythromycin (B)</p> Signup and view all the answers

What adverse effect is extremely rare with Erythromycin?

<p>Allergy (C)</p> Signup and view all the answers

Which antibiotic has a greater effect against anaerobes compared to Erythromycin?

<p>Clindamycin (D)</p> Signup and view all the answers

What is the pharmacologic effect of Diazepam (Valium) according to the text?

<p>Antianxiety (B)</p> Signup and view all the answers

Which antibiotic exhibits cross-allergy with penicillin due to being chemically closely related to Cephalosporins?

<p>Cefotaxime (B)</p> Signup and view all the answers

Which of the following is NOT an adverse effect of Diazepam (Valium) as mentioned in the text?

<p>Hypertension (D)</p> Signup and view all the answers

Which of the following conditions is a contraindication for using Barbiturates based on the text?

<p>Glaucoma (D)</p> Signup and view all the answers

What is the adult oral dose range for Diazepam (Valium) based on the text?

<p>2-10 mg (C)</p> Signup and view all the answers

What is one of the differences between Barbiturates and Non-Barbiturates based on the text?

<p>Cross-allergenicity (D)</p> Signup and view all the answers

Which drug from the provided list is classified as a Non-Barbiturate and has sedative-hypnotic properties?

<p>Methohexital (Brevital) (C)</p> Signup and view all the answers

Which of the following tetracyclines is associated with major adverse effect pseudomembranous colitis?

<p>Doxycycline (Vibramycin) (A)</p> Signup and view all the answers

What is the spectrum of tetracyclines in terms of bacteria they are effective against?

<p>Bacteriostatic to gram-positive and gram-negative bacteria (D)</p> Signup and view all the answers

What is a common adverse effect of tetracyclines related to the developing dentition?

<p>Staining of teeth (C)</p> Signup and view all the answers

Which route of administration is recommended for metronidazole (Flagyl) to be effective against obligate anaerobic microorganisms?

<p>Rectal administration (B)</p> Signup and view all the answers

What is one of the significant contraindications for using tetracyclines?

<p>Liver damage (D)</p> Signup and view all the answers

Which tetracycline has the highest allergenic potential among the options provided?

<p>Minocycline (Minocin, Vectrin) (C)</p> Signup and view all the answers

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