Therapeutic Medications for Osteoporosis

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Which of the following drugs is NOT approved by the FDA for the treatment of osteoporosis?

Alendronate

Strontium ranelate (correct)

Teriparatide

Raloxifene

Which drug class is associated with causing bone loss when used for long-term treatment?

Selective estrogen receptor modulators

Parathyroid hormone analogs

Antiseizure drugs like phenytoin and barbiturates (correct)

Bisphosphonates

Which of the following is NOT a potential cause of bone loss mentioned in the text?

Excessive use of aluminum-containing antacids

Certain cancer treatments

Excessive use of iron supplements (correct)

Gonadotropin-releasing hormone (GnRH) analogs used to treat endometriosis

According to the figure, which drug combination showed the highest efficacy in increasing bone mineral density of the lumbar spine?

PTH (25 μg) + estradiol Signup and view all the answers

Which of the following statements about the figure is correct?

It illustrates the inexorable bone loss without intervention, as seen in the placebo treatment group. Signup and view all the answers

Which medication is approved by the FDA for both the prevention and treatment of postmenopausal osteoporosis?

Alendronate Signup and view all the answers

For which group of patients is alendronate specifically approved for the treatment of osteoporosis?

Men Signup and view all the answers

Which medication is approved for the prevention of postmenopausal osteoporosis?

Raloxifene Signup and view all the answers

Which medication is approved for use by both men and women with glucocorticoid-induced osteoporosis?

Risedronate Signup and view all the answers

Which therapy is specifically approved for the prevention of postmenopausal osteoporosis?

Estrogen/hormone replacement therapy (ERT/HRT) Signup and view all the answers

Which of the following statements about ERT and HRT is correct?

ERT and HRT both increase the risk of venous thromboembolism, and the decision to use them should be made after discussing the benefits and risks with the patient. Signup and view all the answers

Which statement best describes the efficacy of treatments for the prevention of non-vertebral and hip fractures?

The efficacy of treatments is affected by the entry criteria and patient characteristics of the different studies, as shown in Figure 2. Signup and view all the answers

Why has strontium production been permanently discontinued?

Strontium production has been discontinued due to safety concerns, including myocardial infarction, thromboembolic events, and rare but serious skin reactions (DRESS syndrome). Signup and view all the answers

According to the conclusions, which of the following statements about the treatment of osteoporosis is correct?

The primary goal of treatment for osteoporosis should be to prevent fractures. Signup and view all the answers

Which of the following is a correct statement about the mechanisms by which antiresorptive drugs decrease fracture risk?

Increases in BMD contribute to, but are not the only mechanism by which antiresorptive drugs decrease fracture risk. Signup and view all the answers

Therapeutic Medications for Osteoporosis

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