Therapeutic Medications for Osteoporosis
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Questions and Answers

Which of the following drugs is NOT approved by the FDA for the treatment of osteoporosis?

  • Alendronate
  • Strontium ranelate (correct)
  • Teriparatide
  • Raloxifene

Which drug class is associated with causing bone loss when used for long-term treatment?

  • Selective estrogen receptor modulators
  • Parathyroid hormone analogs
  • Antiseizure drugs like phenytoin and barbiturates (correct)
  • Bisphosphonates

Which of the following is NOT a potential cause of bone loss mentioned in the text?

  • Excessive use of aluminum-containing antacids
  • Certain cancer treatments
  • Excessive use of iron supplements (correct)
  • Gonadotropin-releasing hormone (GnRH) analogs used to treat endometriosis

According to the figure, which drug combination showed the highest efficacy in increasing bone mineral density of the lumbar spine?

<p>PTH (25 μg) + estradiol (B)</p> Signup and view all the answers

Which of the following statements about the figure is correct?

<p>It illustrates the inexorable bone loss without intervention, as seen in the placebo treatment group. (B)</p> Signup and view all the answers

Which medication is approved by the FDA for both the prevention and treatment of postmenopausal osteoporosis?

<p>Alendronate (C)</p> Signup and view all the answers

For which group of patients is alendronate specifically approved for the treatment of osteoporosis?

<p>Men (C)</p> Signup and view all the answers

Which medication is approved for the prevention of postmenopausal osteoporosis?

<p>Raloxifene (D)</p> Signup and view all the answers

Which medication is approved for use by both men and women with glucocorticoid-induced osteoporosis?

<p>Risedronate (D)</p> Signup and view all the answers

Which therapy is specifically approved for the prevention of postmenopausal osteoporosis?

<p>Estrogen/hormone replacement therapy (ERT/HRT) (D)</p> Signup and view all the answers

Which of the following statements about ERT and HRT is correct?

<p>ERT and HRT both increase the risk of venous thromboembolism, and the decision to use them should be made after discussing the benefits and risks with the patient. (D)</p> Signup and view all the answers

Which statement best describes the efficacy of treatments for the prevention of non-vertebral and hip fractures?

<p>The efficacy of treatments is affected by the entry criteria and patient characteristics of the different studies, as shown in Figure 2. (D)</p> Signup and view all the answers

Why has strontium production been permanently discontinued?

<p>Strontium production has been discontinued due to safety concerns, including myocardial infarction, thromboembolic events, and rare but serious skin reactions (DRESS syndrome). (A)</p> Signup and view all the answers

According to the conclusions, which of the following statements about the treatment of osteoporosis is correct?

<p>The primary goal of treatment for osteoporosis should be to prevent fractures. (B)</p> Signup and view all the answers

Which of the following is a correct statement about the mechanisms by which antiresorptive drugs decrease fracture risk?

<p>Increases in BMD contribute to, but are not the only mechanism by which antiresorptive drugs decrease fracture risk. (D)</p> Signup and view all the answers

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