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Questions and Answers
Which of the following best describes the Therapeutic Index?
Which of the following best describes the Therapeutic Index?
- The ratio between the dose that produces desirable effects and the dose that produces harmful effects
- The ratio between the dose that produces desirable effects and the dose that kills half the animals
- The ratio between the dose that produces harmful effects and the dose that kills half the animals
- The ratio between the dose that produces harmful effects and the dose that produces desirable effects (correct)
What does LD50 stand for?
What does LD50 stand for?
- Lethal Dose 05%
- Lethal Dose 50 animals
- Lethal Dose 50% (correct)
- Lethal Dose 05 animals
What is the formula for calculating the Therapeutic Index?
What is the formula for calculating the Therapeutic Index?
- TI = LD50 / ED05
- TI = LD50 * ED50
- TI = LD05 / ED50
- TI = LD50 / ED50 (correct)
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Study Notes
Therapeutic Index
- The Therapeutic Index is a measure of the relative safety of a drug, describing the ratio of the dose that produces a toxic effect to the dose that produces a therapeutic effect.
- LD50 stands for Lethal Dose 50%, which is the dose of a drug that is lethal to 50% of the test population.
Calculating Therapeutic Index
- The formula for calculating the Therapeutic Index is: TI = LD50 / ED50, where ED50 is the Effective Dose 50%, which is the dose of a drug that produces a therapeutic effect in 50% of the test population.
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