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Questions and Answers
What is the primary goal of therapeutic drug monitoring?
To achieve optimal therapeutic response, minimize adverse effects, and prevent toxicity
Which type of medications typically require therapeutic drug monitoring?
Medications with narrow therapeutic indices
Why are patients with renal or hepatic impairment candidates for therapeutic drug monitoring?
Because they have altered pharmacokinetics
When are blood samples typically collected for therapeutic drug monitoring?
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What is the purpose of interpreting the results of therapeutic drug monitoring?
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What is the role of analytical methods in therapeutic drug monitoring?
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Study Notes
What is Therapeutic Drug Monitoring?
- The process of measuring the concentration of a drug in a patient's blood to ensure it is within a therapeutic range
- Helps optimize drug therapy, improve patient outcomes, and reduce adverse effects
Goals of Therapeutic Drug Monitoring:
- Achieve optimal therapeutic response
- Minimize adverse effects
- Prevent toxicity
- Individualize dosage regimens
- Monitor patient compliance
Indications for Therapeutic Drug Monitoring:
- Medications with narrow therapeutic indices (e.g., digoxin, aminoglycosides, antiepileptics)
- Patients with altered pharmacokinetics (e.g., renal or hepatic impairment)
- Patients with multiple drug interactions
- Patients who are non-responsive or experiencing adverse effects
Therapeutic Drug Monitoring Process:
- Specimen collection: Blood samples are typically collected at trough levels (just before the next dose)
- Analytical methods: Various laboratory tests, such as chromatography, immunoassays, or mass spectrometry, are used to measure drug concentrations
- Interpretation: Results are compared to established therapeutic ranges to adjust dosage regimens
- Dose adjustment: Dosages are adjusted based on the measured concentrations to achieve optimal therapeutic response
Benefits of Therapeutic Drug Monitoring:
- Improved patient outcomes
- Reduced toxicity and adverse effects
- Enhanced patient safety
- More effective use of medications
- Cost savings through reduced hospitalizations and healthcare utilization
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Description
Test your knowledge on Therapeutic Drug Monitoring, a process that measures the concentration of a drug in a patient's blood to ensure it is within a therapeutic range. Learn about the goals, indications, and process of therapeutic drug monitoring, and how it can improve patient outcomes and reduce adverse effects.
