Therapeutic Drug Monitoring
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Questions and Answers

What is the primary goal of therapeutic drug monitoring?

To achieve optimal therapeutic response, minimize adverse effects, and prevent toxicity

Which type of medications typically require therapeutic drug monitoring?

Medications with narrow therapeutic indices

Why are patients with renal or hepatic impairment candidates for therapeutic drug monitoring?

Because they have altered pharmacokinetics

When are blood samples typically collected for therapeutic drug monitoring?

<p>At trough levels, just before the next dose</p> Signup and view all the answers

What is the purpose of interpreting the results of therapeutic drug monitoring?

<p>To adjust dosage regimens accordingly</p> Signup and view all the answers

What is the role of analytical methods in therapeutic drug monitoring?

<p>To measure drug concentrations using laboratory tests</p> Signup and view all the answers

Study Notes

What is Therapeutic Drug Monitoring?

  • The process of measuring the concentration of a drug in a patient's blood to ensure it is within a therapeutic range
  • Helps optimize drug therapy, improve patient outcomes, and reduce adverse effects

Goals of Therapeutic Drug Monitoring:

  • Achieve optimal therapeutic response
  • Minimize adverse effects
  • Prevent toxicity
  • Individualize dosage regimens
  • Monitor patient compliance

Indications for Therapeutic Drug Monitoring:

  • Medications with narrow therapeutic indices (e.g., digoxin, aminoglycosides, antiepileptics)
  • Patients with altered pharmacokinetics (e.g., renal or hepatic impairment)
  • Patients with multiple drug interactions
  • Patients who are non-responsive or experiencing adverse effects

Therapeutic Drug Monitoring Process:

  1. Specimen collection: Blood samples are typically collected at trough levels (just before the next dose)
  2. Analytical methods: Various laboratory tests, such as chromatography, immunoassays, or mass spectrometry, are used to measure drug concentrations
  3. Interpretation: Results are compared to established therapeutic ranges to adjust dosage regimens
  4. Dose adjustment: Dosages are adjusted based on the measured concentrations to achieve optimal therapeutic response

Benefits of Therapeutic Drug Monitoring:

  • Improved patient outcomes
  • Reduced toxicity and adverse effects
  • Enhanced patient safety
  • More effective use of medications
  • Cost savings through reduced hospitalizations and healthcare utilization

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Description

Test your knowledge on Therapeutic Drug Monitoring, a process that measures the concentration of a drug in a patient's blood to ensure it is within a therapeutic range. Learn about the goals, indications, and process of therapeutic drug monitoring, and how it can improve patient outcomes and reduce adverse effects.

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