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Questions and Answers
What is the enzyme targeted by statins to decrease cholesterol?
What is the enzyme targeted by statins to decrease cholesterol?
- NADPH oxidase
- Pancreatic lipase
- Lipoprotein lipase
- Hydroxymethyl glutaryl CoA reductase (HMGR) (correct)
Which condition might be a risk when using fibric acids and ezetimibe together?
Which condition might be a risk when using fibric acids and ezetimibe together?
- Gastric ulcers
- Kidney stones
- Pancreatitis
- Gall stones (cholithiasis) (correct)
What is the primary method of administration for the active free acid form of fibric acids?
What is the primary method of administration for the active free acid form of fibric acids?
- Topical application
- Subcutaneous injection
- Intravenous injection
- Oral absorption (correct)
Which therapeutic approach inhibits triglyceride biosynthesis and VLDL formation?
Which therapeutic approach inhibits triglyceride biosynthesis and VLDL formation?
What type of chemical class do statins belong to?
What type of chemical class do statins belong to?
Which lipid-lowering agent traps bile acids in the gut and facilitates its excretion?
Which lipid-lowering agent traps bile acids in the gut and facilitates its excretion?
What is the primary mechanism of action of MOA (various) in inhibiting lipolysis?
What is the primary mechanism of action of MOA (various) in inhibiting lipolysis?
What is the major side effect associated with Niacin?
What is the major side effect associated with Niacin?
What type of drug-drug interaction can occur with statins and Niacin?
What type of drug-drug interaction can occur with statins and Niacin?
Why must fibric acids be anionic for activity?
Why must fibric acids be anionic for activity?
Flashcards
HMGR
HMGR
Hydroxymethyl glutaryl CoA reductase, the enzyme targeted by statins to decrease cholesterol.
Fibric Acids & Ezetimibe: Risk
Fibric Acids & Ezetimibe: Risk
Using fibric acids and ezetimibe together increases the risk of gallstones (cholithiasis).
Fibric Acids: Administration
Fibric Acids: Administration
Fibric acids are primarily administered orally, where the active free acid form is absorbed.
Triglyceride Inhibition
Triglyceride Inhibition
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Statins: Chemical Class
Statins: Chemical Class
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Cholestyramine: Function
Cholestyramine: Function
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MOA (Various): Lipolysis Inhibition
MOA (Various): Lipolysis Inhibition
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Niacin: Side Effect
Niacin: Side Effect
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Statins & Niacin: Interaction
Statins & Niacin: Interaction
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Fibric Acids: Anionic Activity
Fibric Acids: Anionic Activity
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Study Notes
Statins
- Statins inhibit HMG-CoA reductase, the enzyme responsible for cholesterol synthesis.
Fibric Acids
- Fibric acids are primarily administered orally as the active free acid form.
- When combined with ezetimibe, fibric acids may increase the risk of myopathy.
Ezetimibe
- Ezetimibe inhibits cholesterol absorption in the small intestine.
Niacin
- Niacin can cause flushing as a major side effect.
- Niacin can interact with statins and increase the risk of myopathy.
MOA Inhibitors
- MOA (monoamine oxidase) inhibitors inhibit lipolysis primarily by blocking the breakdown of triglycerides.
Bile Acid Sequestrants
- Bile acid sequestrants trap bile acids in the gut, preventing reabsorption and leading to their excretion.
Lipid-Lowering Agents
- Fibric acids inhibit triglyceride biosynthesis and VLDL (very low-density lipoprotein) formation.
Drug Mechanisms
- Fibric acids must be anionic for their pharmacological activity.
- Statins belong to the HMG-CoA reductase inhibitor chemical class.
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