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Questions and Answers
What is the structure of Von Willebrand Factor (VWF)?
What is the structure of Von Willebrand Factor (VWF)?
VWF is made in endothelial cells (Weibel Palade bodies, WPB) and in megakaryocytes (alpha granules of platelets).
How does VWF form tubular structures?
How does VWF form tubular structures?
Polymerized VWF forms tubular structures in Weibel-Palade bodies.
What happens to secreted VWF multimers in flowing blood?
What happens to secreted VWF multimers in flowing blood?
Secreted multimers are straightened by elongational forces in flowing blood.
What does VWF interact with in the blood?
What does VWF interact with in the blood?
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What does VWF sense and interact with?
What does VWF sense and interact with?
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