The Ultimate Tablet Production Quiz

Tablets are the most widely used ______ dosage forms

Advantages of tablets include convenient and ______

Disadvantages of tablets include inflexible dosage form and ______ difficulties

Tablet size and shape can vary, such as discoid, oval, square, pentagonal, etc.

Dimetapp is a film-coated ______

Enteric coated ______ include Dulcolax and Arthrotec

Buccal ______ are placed between the cheek and gums and dissolve slowly

Sublingual ______ are placed under the tongue for quick dissolution

Chewable ______ are meant to be chewed before swallowing and often contain sugars or flavoring agents

Lozenges, troches, and lollipops are dissolved slowly in the mouth for localized effects and can be prepared by fusion or candy ______ process

Multiple compressed ______ are made by more than one compression and can be used for extended release

Buffered ______ are prepared with buffers to minimize drug irritation to the upper GI tract

Effervescent ______ release carbon dioxide when placed in water

Instant disintegrating/dissolving ______ are designed to quickly disintegrate without the need for chewing or liquid

Tablet triturates, also known as molded ______, are made for oral administration by a pharmacist

Common tablet production methods include wet granulation, dry granulation, and direct ______

Advantages of gelatin capsules include ______ convenient easily compounded exact doses (compared to other powder dose forms) can be sealed oily (non-polar) liquids can be filled commercial capsule dosage forms can be made readily identifiable by different color combinations, printed letters or numbers on caps

Disadvantages of gelatin capsules include cannot be filled with ______ polar liquids – water or glycerin, propylene glycol cannot be filled with very hygroscopic or deliquescent (melting) substances, or efflorescent substances not useful for volatile compounds since contents are usually released in the stomach, drugs that are irritating to the stomach may cause nausea (vs. enteric coated tablet) capsules will soften or become sticky if stored in un-sealed containers under humid, tropical conditions

A common gelatin capsule size is ______ 000 00 0 1 2 3 4 5

Examples of drugs that can be filled in gelatin capsules include ______ Aspirin 1040 650 520 325 260 195 160 100 Quinine Sulfate 650 390 325 225 195 130 100 65 Sodium Bicarbonate 1430 975 715 510 390 325 260 130

Common gelatin capsule excipients include ______ Diluents o Bulking agents o e.g. lactose monohydrate, microcrystalline cellulose, mannitol, magnesium carbonate Lubricants o lubricants keep the formulation ingredients sticking to the machine parts and to improve formulation flow in the machine o e.g. magnesium stearate – usually.

The gelatin capsule manufacturing process involves ______ Preparation o o o o Gelatin solution is moulded onto metallic pins Pin bars are removed and dried Capsule halves are stripped from the pins Cap and base are cut to proper length and joined

The approximate capacity of gelatin capsules depends on the ______ Capsule Size and Volume (mL)

A disadvantage of gelatin capsules is that they may ______ soften or become sticky if stored in un-sealed containers under humid, tropical conditions