Podcast
Questions and Answers
Which technical property of powder is crucial in tablet manufacturing?
Which technical property of powder is crucial in tablet manufacturing?
- Color & taste
- Oxidation & moisture content
- Homogeneity & segregation tendency (correct)
- Particle size & shape
What is the primary cause of tablet capping?
What is the primary cause of tablet capping?
- Adhesion or sticking of powder material to punch tips
- High friction during tablet ejection
- Low mechanical strength of tablets
- Partial or complete separation of top or bottom layer of the tablets (correct)
What defect arises due to wrong formulation in tablet manufacturing?
What defect arises due to wrong formulation in tablet manufacturing?
- Mottling (correct)
- Cracking
- Chipping
- Binding
What is the consequence of low flowability of powder in tablet manufacturing?
What is the consequence of low flowability of powder in tablet manufacturing?
What is the primary cause of tablet lamination?
What is the primary cause of tablet lamination?
Flashcards
Powder Homogeneity
Powder Homogeneity
The even distribution of ingredients throughout a powder mixture, preventing clumps or layers.
Powder Segregation
Powder Segregation
The tendency for the powder's components to separate based on size or density.
Tablet Capping
Tablet Capping
When the top or bottom layer of a tablet detaches, creating a split.
Tablet Mottling
Tablet Mottling
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Tablet Lamination
Tablet Lamination
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Study Notes
Tablet Manufacturing Properties
- Flowability of powder is a crucial technical property in tablet manufacturing, as it affects the uniformity of the tablets.
Tablet Defects
- Capping is primarily caused by high tablet hardness, which leads to the tablet breaking or separating into two parts.
- Lamination is primarily caused by air entrapment during the compression process, resulting in a layered or laminated structure.
- Cracking is a defect that arises due to wrong formulation in tablet manufacturing, resulting in tablets that break or crack.
Consequences of Poor Powder Properties
- Low flowability of powder can lead to uneven tablet density, resulting in inconsistent tablets.
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Description
Test your knowledge of common issues encountered during tablet manufacturing, such as high weight variation, low mechanical strength, capping, adhesion, and high friction. Learn about the properties of powder and the design and conditions of the press that can affect the manufacturing process.
