5 Questions
Which technical property of powder is crucial in tablet manufacturing?
Homogeneity & segregation tendency
What is the primary cause of tablet capping?
Partial or complete separation of top or bottom layer of the tablets
What defect arises due to wrong formulation in tablet manufacturing?
Mottling
What is the consequence of low flowability of powder in tablet manufacturing?
High weight & dose variation of tablets
What is the primary cause of tablet lamination?
Separation of tablet into two or more distinct layers
Study Notes
Tablet Manufacturing Properties
- Flowability of powder is a crucial technical property in tablet manufacturing, as it affects the uniformity of the tablets.
Tablet Defects
- Capping is primarily caused by high tablet hardness, which leads to the tablet breaking or separating into two parts.
- Lamination is primarily caused by air entrapment during the compression process, resulting in a layered or laminated structure.
- Cracking is a defect that arises due to wrong formulation in tablet manufacturing, resulting in tablets that break or crack.
Consequences of Poor Powder Properties
- Low flowability of powder can lead to uneven tablet density, resulting in inconsistent tablets.
Test your knowledge of common issues encountered during tablet manufacturing, such as high weight variation, low mechanical strength, capping, adhesion, and high friction. Learn about the properties of powder and the design and conditions of the press that can affect the manufacturing process.
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