The Therapeutic Index and Drug Safety Quiz
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Questions and Answers

Which of the following statements about the Therapeutic Index (TI) is correct?

  • The TI is calculated by dividing the Lethal Dose (LD) by the Effective Dose (ED). (correct)
  • The TI is related to the margin of safety concept in the dose-response curve lecture.
  • The TI is calculated by dividing the Effective Dose (ED) by the Lethal Dose (LD).
  • The TI is a measure of the dose that produces harmful effects in 50% of the animals.

    • What does LD50 represent in the context of the Therapeutic Index?

  • The dose that kills half the animals who receive that dose. (correct)
  • The dose that produces desirable effects in 50% of the animals.
  • The dose that kills 5% of the animals.
  • The dose that produces harmful effects in 50% of the animals.

    • What does a higher Therapeutic Index (TI) value indicate?

  • A higher risk of harmful effects.
  • A higher risk of beneficial effects.
  • An ineffective drug.
  • A safer drug. (correct)

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