T2 L2: Ascending and Descending Tracts of the Spinal Cord, 20/10/23, AD

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Which part of the spinal cord receives sensory input?

Dorsal horn

What is the function of cerebral spinal fluid (CSF)?

To protect the spinal cord from injury

Which region of the spinal cord contains lots of white matter?

Lateral columns

What is the main focus of the lecture?

The ascending and descending tracks in the spinal cord

Which part of the spinal cord contains more grey matter?

Cervical region

What is the function of the ventral horn in the spinal cord?

Motor

What type of sensory information is carried by the ascending tracks in the spinal cord?

Proprioceptive

What is the function of the dorsal root ganglia?

Carrying sensory information into the spinal cord

Which part of the brain is responsible for processing somatic sensory information?

Thalamus

What is the main symptom of a lesion in the dorsal column?

Loss of balance

What is the Romberg sign used to assess?

Proprioception

Which part of the spinal cord is responsible for relaying pain information to the brain?

Dorsal horn

Which region of the spinal cord do fibers from the lower limb tend to sit in the anterolateral column?

Lateral

Where do second order neurons from the anterolateral column ascend towards?

The thalamus

What happens to the axons of second order neurons in the anterolateral column after they cross the midline?

They project towards the sensory cortex

What type of injury would result in the loss of pain in the lower limb first?

Outer tract injury

Which pathway controls all of your skeletal muscles?

Pyramidal tracts

Where do the pyramidal tracts pass through?

The pyramids of the medulla

Where do the upper motor neurons project from?

The cerebral cortex

What happens if there is an injury to the dorsal aspect of the lateral column?

Loss of proprioception in the left lower limb

Which pathway carries information about light touch from the skin?

Dorsal column medial lemniscus pathway

Where do the first order neurons in the dorsal column medial lemniscus pathway enter the spinal cord?

Dorsal roots

Which part of the dorsal column is responsible for carrying information from the upper limb?

Fasciculus cuneatus

Where do the second order neurons in the dorsal column medial lemniscus pathway sit within the medulla?

Nucleus cuneatus

Which part of the motor cortex innovates the lower limb?

Medial parts

Where do the axons of the upper motor neurons descend through?

The internal capsule

What is the fate of the brains and the cerebral paid uncles?

They cross the midline to enter the pyramids

What percentage of fibers cross the midline to enter the pyramids?

80%

Which part of the motor cortex innovates the upper limb?

Lateral parts

Which part of the brain stem do the axons of the upper motor neurons pass through?

The ventral part

What type of sensory information is carried in the ascending tracts of the spinal cord?

Proprioceptive and exteroceptive information

What is the function of the dorsal column-medial lemniscus pathway?

To provide the brain with positional information

Where do first-order neurons in the dorsal column-medial lemniscus pathway enter the spinal cord?

Dorsal root

Which part of the spinal cord receives sensory input?

Dorsal horn

What is the main symptom of a lesion in the anterolateral column?

Loss of pain, temperature, and crude touch on the opposite side

What is the Romberg's sign used to assess?

Coordination and balance

What type of injury would result in the loss of pain in the upper limb first?

Injury to the anterolateral column

What is the fate of the axons of second-order neurons in the dorsal column-medial lemniscus pathway after they cross the midline?

They ascend to the thalamus

What is the function of the ventral column in the spinal cord?

To carry motor information

What is the main focus of the lecture?

The organization of the tracts

Which part of the spinal cord is responsible for relaying sensory information to the brain?

Dorsal horn

Where do the upper motor neurons project from?

Cerebral cortex

What is the function of the ventral horn in the spinal cord?

Motor neuronal cell bodies

Which part of the brain is responsible for processing somatic sensory information?

Cerebral cortex

What happens if there is an injury to the dorsal aspect of the lateral column?

Loss of proprioception

What is the function of the dorsal root ganglia?

Receiving sensory input

Which part of the dorsal column is responsible for carrying information from the upper limb?

Cuneate fasciculus

What is the main function of cerebrospinal fluid (CSF)?

Protection of the brain

Where do second order neurons from the anterolateral column ascend towards?

Brainstem

What type of injury would result in the loss of pain and temperature sensation in the lower limb first?

Dorsal root ganglia injury

Which tract carries unconscious muscle proprioception from muscle spindles and golgi tendon organs?

Spinocerebellar tracts

Which tract carries proprioceptive information from the trunk and lower limb?

Dorsal and ventral spinocerebellar tracts

Where do the spinocerebellar tracts terminate in the cerebellum?

On the same side

Which tract comprises of multiple tracts that carry proprioceptive information from the upper limb?

Cuneocerebellar tract

Which tract crosses back in the dorsal horn of the spinal cord?

Dorsal spinocerebellar tract

Which tract controls smooth motor coordination?

Ventral spinocerebellar tract

Which descending tract is mainly from the cerebral cortex or brainstem and is responsible for voluntary motor control?

Corticospinal tract

What is the main symptom of a lesion in the corticospinal tract?

Increased muscle tone

What is the main symptom of a lesion in the lower motor neurons?

Flaccid paralysis

Which disease selectively affects both lower and upper motor neurons, leading to progressive muscle weakness and atrophy?

Amyotrophic lateral sclerosis

Study Notes

Organization and Function of the Spinal Cord

  • The lecture focuses on the ascending and descending tracks in the spinal cord that carry information to and from the brain.
  • The previous lecture covered the ventricular system, including the ventricles, production and circulation of cerebrospinal fluid (CSF), and disorders affecting the system.
  • The spinal cord consists of grey matter (organized in an h shape) and white matter (organized into columns or tracks).
  • The grey matter includes the dorsal horn (sensory), ventral horn (motor), and lateral horn (sympathetic neurons).
  • Interneurons in the grey matter form circuits involved in reflexes.
  • The amount of grey matter varies at different levels of the spinal cord, with more in the cervical and lumbar regions due to innervation of the upper and lower limbs.
  • The white matter contains ascending tracks (carrying sensory information) and descending tracks (carrying motor information).
  • Ascending tracks are located in the dorsal and lateral columns, while descending tracks are found in the ventral and lateral columns.
  • Sensory information carried in the ascending tracks includes proprioceptive (from within the body) and exteroceptive (from outside the body) information.
  • The dorsal column medial lemniscal pathway carries information about light touch, vibrations, and proprioception from muscles and joints to the cortex.
  • The first, second, and third order neurons are involved in this pathway, with primary sensory neurons entering the dorsal column on the same side and ascending to the brainstem.
  • In the brainstem, the axons of the first order neurons synapse with second order neurons in the nucleus gracilis or nucleus cuneatus, depending on whether the information is from the lower or upper limb.

Quiz: Test your knowledge on Spinal Cord Tracts and Proprioceptive Information Challenge yourself with this quiz on spinal cord tracts and proprioceptive information. Explore the main tracks involved in transmitting information from the lower and upper limbs, and discover how they contribute to our sense of movement and coordination. Put your knowledge to the test and see how much you know about these important aspects of the nervous system.

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