L21. Neuroscience - Anatomy of the Spinal Cord
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Questions and Answers

What anatomical structure marks the beginning of the spinal cord?

  • Foramen magnum (correct)
  • Cervical enlargement
  • Dural sac
  • Conus medullaris

Which spinal cord enlargement corresponds with the spinal levels C5 to T1?

  • Sacral enlargement
  • Thoracic enlargement
  • Cervical enlargement (correct)
  • Lumbosacral enlargement

What is the total number of pairs of spinal nerves that arise from the spinal cord?

  • 33 pairs
  • 30 pairs
  • 32 pairs
  • 31 pairs (correct)

The conus medullaris is located at the interface of which lumbar vertebrae?

<p>L1 and L2 (D)</p> Signup and view all the answers

Which part of the spinal cord contains the dorsal horn, ventral horn, and the intermediate zone?

<p>Gray matter (D)</p> Signup and view all the answers

What defines the anterior gray horns in the spinal cord?

<p>Somatotopic organization (C)</p> Signup and view all the answers

What unique feature does the spinal cord possess compared to other components of the CNS?

<p>Extrinsic segmentation (A)</p> Signup and view all the answers

Which of the following correctly describes the arrangement of white matter in the spinal cord?

<p>Organized into defining funiculi and fasciculi (A)</p> Signup and view all the answers

What characteristic distinguishes the lumbar level of the spinal cord from the thoracic level?

<p>It has a large substantia gelatinosa. (B)</p> Signup and view all the answers

Which statement accurately describes the sacral level of the spinal cord?

<p>It has a quadrangular-shaped gray matter structure. (A), It has a large intermediolateral cell column area. (B)</p> Signup and view all the answers

What is the role of the lumbar cistern in the spinal cord?

<p>It contains the cauda equina and cerebral spinal fluid. (D)</p> Signup and view all the answers

Which fasciculus contains primary sensory axons from spinal cord segments C2-T6?

<p>Fasciculus cuneatus (D)</p> Signup and view all the answers

What bounds the fasciculus gracilis laterally?

<p>Posterior intermediate sulcus (B)</p> Signup and view all the answers

Which structure provides a non-neuronal extension from the conus medullaris?

<p>Filum terminale (A)</p> Signup and view all the answers

In the context of spinal cord anatomy, what is the relationship of the fasciculus cuneatus to the posterior lateral sulcus?

<p>It is positioned lateral to the fasciculus gracilis. (C)</p> Signup and view all the answers

What are the primary components of white matter in the spinal cord?

<p>Myelinated axons forming funiculi and fasciculi. (D)</p> Signup and view all the answers

Where is the cauda equina found in relation to the lumbar cistern?

<p>Within the lumbar cistern. (C)</p> Signup and view all the answers

What distinguishes the dorsal funiculus in the spinal cord?

<p>It is also known as the dorsal columns. (C)</p> Signup and view all the answers

What is the anatomical significance of the anterior lateral sulcus?

<p>It defines the exit points for somatic motor nerve roots. (C)</p> Signup and view all the answers

What is the main function of the posterior intermediate sulcus?

<p>It separates the dorsal funiculus at specific spinal levels. (D)</p> Signup and view all the answers

What type of nerve roots does the cauda equina give rise to?

<p>Lower lumbar, sacral, and coccygeal nerves. (B)</p> Signup and view all the answers

What anatomical structures are defined as funiculi?

<p>Regions containing myelinated axons in the spinal cord. (B)</p> Signup and view all the answers

Which structure is responsible for the exit of sensory nerve roots into the spinal cord?

<p>Posterior lateral sulcus (A)</p> Signup and view all the answers

What are the three regions that motor neurons are somatotopically arranged into within the grey matter of the ventral spinal cord?

<p>Flexors, Extensors, Axial musculature (A)</p> Signup and view all the answers

Which characteristic does not apply to the thoracic level of the spinal cord?

<p>Increased area of gray matter compared to cervical level (B)</p> Signup and view all the answers

Which section of the spinal cord is characterized by providing motor neurons for the upper limbs?

<p>Cervical Level (A)</p> Signup and view all the answers

What unique feature is found in the thoracic cord that is not present in the cervical cord?

<p>Nucleus dorsalis of Clarke (B)</p> Signup and view all the answers

Which of the following accurately describes the shape of the spinal cord at the cervical level?

<p>Oval-shaped and large diameter (B)</p> Signup and view all the answers

The ventral horn of the spinal cord is primarily associated with which type of neurons?

<p>Motor neurons (C)</p> Signup and view all the answers

In which spinal cord region is the ratio of white matter to gray matter notably increased?

<p>Thoracic Level (A)</p> Signup and view all the answers

What is the primary function of axially located muscles according to the spinal cord motor mapping?

<p>Postural stability and core support (B)</p> Signup and view all the answers

Which spinal segment contains the pre-ganglionic sympathetic neurons in the lateral horn?

<p>T1 to L2 (B)</p> Signup and view all the answers

What mapping is illustrated by Figure 5a regarding motor neuron distribution?

<p>Axial musculature of the left side (A)</p> Signup and view all the answers

What is the primary function of the dorsal horn in the spinal cord?

<p>Receiving sensory (afferent) input (A)</p> Signup and view all the answers

Where are the preganglionic sympathetic motor neurons located?

<p>T1-L2 (B)</p> Signup and view all the answers

Which structure is characteristic of the lateral horn in the spinal cord?

<p>Prominently displayed in thoracic and upper lumbar levels (B)</p> Signup and view all the answers

What defines the fasciculus cuneatus in the dorsal funiculus?

<p>Laterally positioned columns (A)</p> Signup and view all the answers

What is the composition of gray matter in the spinal cord?

<p>Neurons, glial cells, axons, and dendrites (C)</p> Signup and view all the answers

Which commissure contains heavily-myelinated axon fibers that cross to the opposite side?

<p>Ventral white commissure (C)</p> Signup and view all the answers

What is the role of the ventral (anterior) horn?

<p>It provides motor output (C)</p> Signup and view all the answers

Which part of the spinal cord is associated with the region of the lateral horn?

<p>Thoracic and upper lumbar levels (A)</p> Signup and view all the answers

What is the somatotopic organization of the anterior horn?

<p>Arranged according to body part functionality (A)</p> Signup and view all the answers

Where are pregnancy sympathetic motor neurons found within the spinal cord?

<p>T1-L2 (D)</p> Signup and view all the answers

Flashcards

Where does the spinal cord start and end?

The spinal cord begins where the medulla oblongata transitions into the spinal cord at the foramen magnum and ends at the conus medullaris between L1 and L2 vertebrae.

What makes the spinal cord uniquely segmented?

The spinal cord is unique because it is segmented externally, giving rise to 31 pairs of spinal nerves.

Where are the cervical and lumbosacral enlargements located?

The cervical enlargement is located from C5 to T1 vertebrae and the lumbosacral enlargement is located from L2 to S3 vertebrae.

What features are present on the ventral surface of the spinal cord?

The ventral surface of the spinal cord is located on the front side and contains the ventral median fissure.

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What features are present on the dorsal surface of the spinal cord?

The dorsal surface of the spinal cord is located on the back side and contains the dorsal median sulcus.

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What is found within the white matter of the spinal cord?

The white matter of the spinal cord contains tracts of myelinated axons, which are organized into funiculi and fasciculi.

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What is found within the gray matter of the spinal cord?

The gray matter of the spinal cord forms a butterfly-shaped region containing neuron cell bodies, which are organized into horns - dorsal, ventral, and intermediate.

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What connects the left and right sides of the spinal cord?

The gray and white commissures connect the left and right sides of the spinal cord in the gray and white matter, respectively.

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Conus Medullaris

The lower end of the spinal cord, located at the L1-L2 vertebral levels.

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Lumbar Cistern

The space within the dura mater (a protective membrane) that extends from the L1-L2 level to the S2 level, filled with cerebrospinal fluid.

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Cauda Equina

A bundle of nerve roots (dorsal and ventral) that extend from the spinal cord in the lumbar cistern, responsible for innervating lower limbs and pelvic organs.

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Filum Terminale

A non-neuronal filament extending from the conus medullaris to the end of the dura mater, composed of pia mater.

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Anterior Median Sulcus

A groove on the anterior (front) surface of the spinal cord.

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Anterior Lateral Sulcus

A groove on the anterior (front) surface of the spinal cord where ventral nerve roots (motor) exit.

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Posterior Median Sulcus

A groove on the posterior (back) surface of the spinal cord.

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Posterior Lateral Sulcus

A groove on the posterior (back) surface of the spinal cord where dorsal nerve roots (sensory) enter.

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Posterior Intermediate Sulcus

A septum (partition) extending from the C1 to T6 level on the posterior (back) surface of the spinal cord.

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White Matter of the Spinal Cord

The white matter of the spinal cord is composed of myelinated axons, which are responsible for transmitting information throughout the nervous system.

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Somatotopic Arrangement

The gray matter of the ventral spinal cord contains motor neurons arranged in three areas: flexors, extensors, and axial musculature. These neurons are mapped to specific body regions.

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Cervical Enlargement

The cervical enlargement of the spinal cord is responsible for controlling the upper limbs.

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Lumbar Sacral Enlargement

The lumbar sacral enlargement of the spinal cord is responsible for controlling the lower limbs.

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Contralateral Control

Motor neurons controlling muscles on the same side of the body are located on the opposite side of the spinal cord. This is known as contralateral control.

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Medial Axial Muscles

Motor neurons controlling axial muscles (trunk muscles) are located medially within the ventral horn. These include muscles like the back muscles and abdominal muscles.

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Lateral Appendicular Muscles

Motor neurons controlling appendicular muscles (limb muscles) are located laterally within the ventral horn. These include muscles like the arm and leg muscles.

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Dorsal Flexors

Motor neurons controlling flexor muscles are located dorsally within the ventral horn. These muscles bring body parts closer together.

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Ventral Extensors

Motor neurons controlling extensor muscles are located ventrally within the ventral horn. These muscles extend body parts away from the body.

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Cervical Level

The cervical level of the spinal cord is oval-shaped and has a large diameter due to the presence of motor neurons for the upper limbs.

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Thoracic Level

The thoracic level of the spinal cord is circular and smaller than the cervical level. This region has a smaller amount of gray matter and a higher ratio of white matter to gray matter.

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Fasciculus gracilis

Paired columns of white matter located in the dorsal funiculus, spanning the entire length of the spinal cord.

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Fasciculus cuneatus

Paired columns of white matter located in the dorsal funiculus, spanning from cervical nerve 1 to thoracic nerve 6.

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Gray matter

The central region of the spinal cord, composed primarily of neuronal cell bodies, axons, and dendrites.

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Dorsal horn

The sensory region of the gray matter, receives sensory input from the body.

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Substantia gelatinosa

The top region of the dorsal horn, responsible for processing pain and temperature sensation.

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Neck of dorsal horn

The middle region of the dorsal horn, involved in processing proprioceptive information from muscles and joints.

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Base of dorsal horn

The base of the dorsal horn, responsible for processing proprioceptive information from muscles and joints.

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Ventral (anterior) horn

The motor region of the gray matter, responsible for sending motor impulses to the body.

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Intermediolateral zone

The region of the gray matter that contains the lateral horn, responsible for processing autonomic functions.

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Lateral horn

A part of the intermediolateral zone, prominently displayed in the thoracic and lumbar spinal cord, responsible for controlling sympathetic nervous system functions.

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What is the fasciculus cuneatus?

The fasciculus cuneatus is a bundle of sensory axons in the dorsal column of the spinal cord, conveying touch, pressure, vibration, and proprioceptive information from the upper body (C2-T6) to the brain.

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What is the fasciculus gracilis?

The fasciculus gracilis is a bundle of sensory axons in the dorsal column of the spinal cord, conveying touch, pressure, vibration, and proprioceptive information from the lower body (T6-S5 & Co1) to the brain.

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What is the posterior intermediate sulcus?

The posterior intermediate sulcus separates the fasciculus cuneatus and fasciculus gracilis, two major sensory pathways in the dorsal column of the spinal cord.

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What is the posterior lateral sulcus?

The posterior lateral sulcus is a groove on the dorsal surface of the spinal cord, marking the lateral boundary of the fasciculus cuneatus.

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What is the posterior median sulcus?

The posterior median sulcus is a groove on the dorsal surface of the spinal cord, marking the midline between the left and right halves of the spinal cord.

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Study Notes

Spinal Cord Organization

  • The spinal cord begins at the foramen magnum and ends at the conus medullaris, where it transitions into the spinal cord at the plane of foramen magnum
  • It ends as the conus medullaris at the interface between Lumbar vertebrae LV1 and LV2
  • The spinal cord is the only "extrinsically segmented component of the CNS"—giving rise to 31 pairs of spinal nerves
  • There are 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, and 1 coccygeal nerve pairs

Spinal Cord Enlargements

  • Cervical enlargement (C5-T1)
  • Lumbosacral enlargement (L2-S3)
  • The spinal cord's relationship with its surrounding anatomical structures in the dural sac

Surface Anatomy

  • Ventral (anterior) surface includes the anterior median sulcus/fissure & anterior lateral sulcus/fissure
    • The anterior lateral sulcus is where the ventral spinal rootlets (somatic motor) exit the spinal cord.
  • Dorsal (posterior) surface includes the posterior median sulcus & posterior lateral sulcus
    • The posterior lateral sulcus is where the dorsal spinal rootlets (sensory) enter the spinal cord

Cross-Sectional Anatomy

  • White matter is composed of myelinated axons, stained brown using osmium-tetroxide staining
    • The white matter is further divided into funiculi (or gross descriptive regions)
      • Dorsal funiculus (also known as “the dorsal columns”)
      • Lateral funiculus
      • Anterior funiculus
    • Fasciculi are defined bundles of axons (tracts) within the funiculi
  • Gray matter is composed of neurons, glial cells, axons, and dendrites
    • Divided into horns or columns
      • Dorsal horn (sensory input); subdivided into head (substantia gelatinosa), neck, and base
      • Ventral horn (motor output)
  • Commissures are bundles of axons crossing to the opposite side of the spinal cord
    • Includes ventral white commissure, ventral gray commissure, & dorsal gray commissure

Regional Variation

  • Cervical level: oval-shaped, large diameter, large amount of gray matter, lots of white matter , has a posterior intermediate sulcus and septum.
  • Thoracic level: circular-shaped, smaller diameter than cervical, decreased gray matter area compared to cervical, and higher ratio of white matter to gray matter
  • Lumbar level: larger diameter than thoracic, more white & gray matter, no posterior intermediate sulcus, and has a large substantia gelatinosa
  • Sacral level: rounded shape, small diameter, more gray matter than white matter, large substantia gelatinosa, and has intermediolateral cell column containing preganglionic parasympathetic neurons

Additional Details

  • Filum terminale: A non-neuronal medial filament extending from the conus medullaris to the terminal end of the dura sac.
  • Lumbar cistern: The subarachnoid space within the dura sac that extends from LV1-2 to SV2 and is filled with CSF, clinically used for lumbar puncture to obtain CSF samples
  • Cauda equina: Located within the lumbar cistern, contains the elongated dorsal and ventral roots of lower lumbar, sacral, and coccygeal nerves
  • Intermedial zone (zona intermedia): Contains the lateral horn; prominently displayed in cross sections of thoracic and upper lumbar levels, and also seen in cross sections of the sacral level; contains preganglionic sympathetic motor neurons and preganglionic parasympathetic motor neurons at the level of S2-S4 of the spinal cord
  • Somatotopic arrangement of motor neurons: arranged within the grey matter of the ventral spinal cord in three regions (flexors, extensors and axial musculature); mapped to the body

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Description

This quiz covers the organization and anatomical structure of the spinal cord, including its segments, enlargements, and surface anatomy. Understand the critical features such as spinal nerve pairs and the relationship with surrounding structures. Test your knowledge on the spinal cord's functional and structural components.

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