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Questions and Answers
Which part of the nephron is responsible for most of the reabsorption work?
Which part of the nephron is responsible for most of the reabsorption work?
- Collecting duct
- Distal convoluted tubule (DCT)
- Loop of Henle (LoH)
- Proximal convoluted tubule (PCT) (correct)
What percentage of the filtrate is typically reabsorbed by the nephron?
What percentage of the filtrate is typically reabsorbed by the nephron?
- 90%
- 65%
- 99.5% (correct)
- 75%
What maintains a constant Glomerular Filtration Rate (GFR)?
What maintains a constant Glomerular Filtration Rate (GFR)?
- Autoregulation via the juxtaglomerular apparatus (correct)
- Hormones
- Blood pressure
- Osmotic pressure
What role does aldosterone play in the nephron?
What role does aldosterone play in the nephron?
Which part of the nephron is mainly responsible for secretion activities?
Which part of the nephron is mainly responsible for secretion activities?
What is one of the main functions of the Loop of Henle?
What is one of the main functions of the Loop of Henle?
What do juxtaglomerular cells primarily monitor?
What do juxtaglomerular cells primarily monitor?
Which hormone is responsible for controlling the reabsorption of water in the distal convoluted tubule?
Which hormone is responsible for controlling the reabsorption of water in the distal convoluted tubule?
What is the primary function of the kidneys?
What is the primary function of the kidneys?
What helps control blood pH in the nephron?
What helps control blood pH in the nephron?
Where does the collecting duct empty urine?
Where does the collecting duct empty urine?
Which structure carries urine from the kidneys to the bladder?
Which structure carries urine from the kidneys to the bladder?
What is the size and shape of the kidney?
What is the size and shape of the kidney?
Which part of the kidney contains cone-shaped structures called pyramids?
Which part of the kidney contains cone-shaped structures called pyramids?
What is the structural and functional unit of the kidney?
What is the structural and functional unit of the kidney?
Which hormone stimulates hemopoiesis?
Which hormone stimulates hemopoiesis?
What is the function of the renal pelvis?
What is the function of the renal pelvis?
What percentage of nephrons are cortical?
What percentage of nephrons are cortical?
What activates the stretch receptors in the bladder wall?
What activates the stretch receptors in the bladder wall?
Which part of the nephron is responsible for plasma filtration?
Which part of the nephron is responsible for plasma filtration?
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Study Notes
Primary Functions of the Kidneys
- Main role is to filter blood and reclaim most water and solutes for the body.
- Kidneys also produce hormones but this is secondary to their filtering capacity.
Urinary Structures
- Ureter carries urine from the kidneys to the bladder.
- Urethra dispels urine from the bladder to the outside.
Anatomy of the Kidney
- Kidneys are bean-shaped and approximately the size of a fist (around 11 cm long).
- Located behind the peritoneum on the posterior abdominal wall.
Internal Anatomy of the Kidney
- Medulla contains cone-shaped structures known as renal pyramids.
- Renal pelvis functions to drain urine from the kidney into the ureter.
Nephron
- The nephron is the kidney's structural and functional unit.
- Renal corpuscle within the nephron is responsible for the filtration of plasma.
- 85% of nephrons in the kidneys are classified as cortical nephrons.
- Renal tubules handle reabsorption and secretion processes.
Hormonal Functions of the Kidneys
- Erythropoietin, produced by the kidneys, stimulates the formation of red blood cells (hemopoiesis).
- Average Glomerular Filtration Rate (GFR) is about 125 ml/min.
- Calcitriol, a hormone, aids in calcium reabsorption in the kidneys.
Micturition Reflex
- Stretch receptors in the bladder wall are activated by urine filling the bladder.
- The pons and cerebrum increase conscious awareness of the need to urinate.
- External urethral sphincter is controlled by skeletal muscle, allowing voluntary control over urination.
Glomerular Filtration Rate
- High GFR can lead to loss of beneficial substances due to rapid fluid passage through nephrons.
- GFR is kept constant through autoregulation via the juxtaglomerular apparatus.
Tubular Reabsorption
- Around 99.5% of the nephron filtrate is reabsorbed back into the body.
- Proximal convoluted tubule (PCT) is primarily responsible for reabsorption operations.
- ADH (antidiuretic hormone) regulates water reabsorption in the distal convoluted tubule (DCT).
Tubular Secretion
- The distal convoluted tubule (DCT) is most active in the secretion process.
- Secretion of H+ ions helps to control blood pH in the nephron.
Loop of Henle
- The Loop of Henle establishes a salt gradient in the medulla, crucial for concentrating urine.
- Juxtamedullary nephrons feature long Loops of Henle facilitating this gradient.
Juxtaglomerular Apparatus (JGA)
- Juxtaglomerular cells monitor blood pressure, playing a key role in renal regulation.
- Macula densa cells detect changes in filtrate flow, adjusting nephron function accordingly.
Collecting Duct
- Aldosterone controls Na+ reabsorption in the collecting duct, influencing blood pressure and volume.
- Collecting ducts empty urine into papillary ducts, leading toward the urinary bladder.
Miscellaneous Functions
- The renal capsule surrounds and protects the kidneys, providing vital structural support.
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