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Questions and Answers
Which neuronal type is characterized by a continuous dendrite and axon, with the cell body situated to the side, and is predominantly found in the peripheral nervous system?
Which neuronal type is characterized by a continuous dendrite and axon, with the cell body situated to the side, and is predominantly found in the peripheral nervous system?
A neuron transmits an efferent signal to stimulate the contraction of the bicep muscle. What functional class does this neuron belong to?
A neuron transmits an efferent signal to stimulate the contraction of the bicep muscle. What functional class does this neuron belong to?
Which type of neuron is most abundant in the central nervous system and characterized by multiple dendrites and one axon?
Which type of neuron is most abundant in the central nervous system and characterized by multiple dendrites and one axon?
If a drug selectively impaired the function of interneurons, which of the following functions would be MOST directly affected?
If a drug selectively impaired the function of interneurons, which of the following functions would be MOST directly affected?
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A researcher is studying neurons involved in relaying visual information from the retina to the brain. Which type of neuron is MOST likely involved in this pathway?
A researcher is studying neurons involved in relaying visual information from the retina to the brain. Which type of neuron is MOST likely involved in this pathway?
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Which of the following accurately describes the role of visceral sensory neurons?
Which of the following accurately describes the role of visceral sensory neurons?
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Which of the following structures is responsible for transmitting electrical signals away from the cell body of a neuron?
Which of the following structures is responsible for transmitting electrical signals away from the cell body of a neuron?
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Damage to the somatic motor neurons would result in which of the following?
Damage to the somatic motor neurons would result in which of the following?
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In a reflex arc, which type of neuron is responsible for directly stimulating a muscle to contract in response to a sensory input?
In a reflex arc, which type of neuron is responsible for directly stimulating a muscle to contract in response to a sensory input?
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Which of the following is the primary function of the axon terminals?
Which of the following is the primary function of the axon terminals?
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A lesion restricted to the anterior gray horn of the spinal cord would most likely result in which of the following deficits?
A lesion restricted to the anterior gray horn of the spinal cord would most likely result in which of the following deficits?
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Which of the following describes the most direct path for a motor command originating in the central nervous system to reach a skeletal muscle?
Which of the following describes the most direct path for a motor command originating in the central nervous system to reach a skeletal muscle?
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What would be the most likely consequence of a drug that selectively blocks acetylcholinesterase (AChE) at the synapse?
What would be the most likely consequence of a drug that selectively blocks acetylcholinesterase (AChE) at the synapse?
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If a researcher selectively damaged the dorsal root ganglia, which of the following sensory functions would be most affected?
If a researcher selectively damaged the dorsal root ganglia, which of the following sensory functions would be most affected?
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A patient exhibits impaired function of visceral motor nuclei. In which region of the spinal cord would damage most likely be found?
A patient exhibits impaired function of visceral motor nuclei. In which region of the spinal cord would damage most likely be found?
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How does the autonomic nervous system (ANS) differ structurally from the somatic nervous system in its path from the CNS to the effector?
How does the autonomic nervous system (ANS) differ structurally from the somatic nervous system in its path from the CNS to the effector?
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Which event is most directly triggered by the influx of $Ca^{2+}$ into the axon terminal during synaptic transmission?
Which event is most directly triggered by the influx of $Ca^{2+}$ into the axon terminal during synaptic transmission?
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Which of the following best describes the primary function of the filtration membrane within the renal corpuscle?
Which of the following best describes the primary function of the filtration membrane within the renal corpuscle?
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What is the primary function of the proximal convoluted tubule (PCT) in the process of urine formation?
What is the primary function of the proximal convoluted tubule (PCT) in the process of urine formation?
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How does the loop of Henle contribute to urine formation?
How does the loop of Henle contribute to urine formation?
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What regulatory mechanism primarily governs the function of the distal convoluted tubule (DCT)?
What regulatory mechanism primarily governs the function of the distal convoluted tubule (DCT)?
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How does antidiuretic hormone (ADH) influence the function of the collecting duct?
How does antidiuretic hormone (ADH) influence the function of the collecting duct?
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Which waste product is produced during the breakdown of amino acids?
Which waste product is produced during the breakdown of amino acids?
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What is the functional relationship between the afferent and efferent arterioles and the glomerulus?
What is the functional relationship between the afferent and efferent arterioles and the glomerulus?
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Given their anatomical location relative to the kidneys, what is a key consideration regarding the adrenal glands?
Given their anatomical location relative to the kidneys, what is a key consideration regarding the adrenal glands?
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If a patient presents with significantly decreased blood sodium levels and chronically low blood pressure, which adrenal cortex zone is most likely malfunctioning?
If a patient presents with significantly decreased blood sodium levels and chronically low blood pressure, which adrenal cortex zone is most likely malfunctioning?
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A researcher is investigating a new drug that selectively inhibits the action of ACTH on the adrenal cortex. Which of the following hormonal responses would be most directly affected by this drug?
A researcher is investigating a new drug that selectively inhibits the action of ACTH on the adrenal cortex. Which of the following hormonal responses would be most directly affected by this drug?
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A patient is diagnosed with a tumor in the adrenal cortex that causes excessive secretion of androgens. What would be the most likely set of symptoms observed in an adult female patient?
A patient is diagnosed with a tumor in the adrenal cortex that causes excessive secretion of androgens. What would be the most likely set of symptoms observed in an adult female patient?
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During a stressful situation, the adrenal medulla releases catecholamines. What is the primary mechanism by which epinephrine contributes to increased blood glucose levels?
During a stressful situation, the adrenal medulla releases catecholamines. What is the primary mechanism by which epinephrine contributes to increased blood glucose levels?
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A researcher is studying the effects of a drug that selectively targets the Zona Reticularis of the adrenal cortex. Which of the following outcomes would provide the strongest evidence that the drug is functioning as intended?
A researcher is studying the effects of a drug that selectively targets the Zona Reticularis of the adrenal cortex. Which of the following outcomes would provide the strongest evidence that the drug is functioning as intended?
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How would the long-term use of a medication that mimics the effects of aldosterone MOST directly impact potassium levels, and where would this effect primarily manifest?
How would the long-term use of a medication that mimics the effects of aldosterone MOST directly impact potassium levels, and where would this effect primarily manifest?
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Damage to the sella turcica would MOST directly endanger which endocrine structure?
Damage to the sella turcica would MOST directly endanger which endocrine structure?
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How does the anatomical relationship between the hypothalamus and the pituitary gland MOST directly facilitate endocrine control?
How does the anatomical relationship between the hypothalamus and the pituitary gland MOST directly facilitate endocrine control?
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Which structural feature is MOST responsible for differentiating the anterior pituitary (adenohypophysis) from the posterior pituitary (neurohypophysis) in terms of function?
Which structural feature is MOST responsible for differentiating the anterior pituitary (adenohypophysis) from the posterior pituitary (neurohypophysis) in terms of function?
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A new drug is designed to specifically enhance glucose synthesis and glycogen formation. This drug would MOST likely mimic the effects of hormones produced by which region of the adrenal gland?
A new drug is designed to specifically enhance glucose synthesis and glycogen formation. This drug would MOST likely mimic the effects of hormones produced by which region of the adrenal gland?
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A pharmaceutical company is developing a drug to precisely control thyroid hormone levels. Which mechanism would be the MOST effective target for this drug to achieve highly specific regulation?
A pharmaceutical company is developing a drug to precisely control thyroid hormone levels. Which mechanism would be the MOST effective target for this drug to achieve highly specific regulation?
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A researcher is investigating the effects of chronic stress on reproductive function in males. Which hormonal interaction is MOST likely to be disrupted by elevated cortisol levels, leading to decreased testosterone production?
A researcher is investigating the effects of chronic stress on reproductive function in males. Which hormonal interaction is MOST likely to be disrupted by elevated cortisol levels, leading to decreased testosterone production?
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A patient presents with symptoms of acromegaly (excess GH). Further investigation reveals a pituitary adenoma that is secreting excessive GH. Which of the following therapeutic strategies would MOST directly address the cause of acromegaly in this patient?
A patient presents with symptoms of acromegaly (excess GH). Further investigation reveals a pituitary adenoma that is secreting excessive GH. Which of the following therapeutic strategies would MOST directly address the cause of acromegaly in this patient?
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A woman is having difficulty lactating after childbirth. Assuming her prolactin levels are normal, which of the following hormonal imbalances is the LEAST likely cause of her lactation insufficiency?
A woman is having difficulty lactating after childbirth. Assuming her prolactin levels are normal, which of the following hormonal imbalances is the LEAST likely cause of her lactation insufficiency?
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A researcher is studying the coordinated hormonal events that regulate the menstrual cycle. Which of the following sequences accurately reflects the hormonal cascade leading to ovulation?
A researcher is studying the coordinated hormonal events that regulate the menstrual cycle. Which of the following sequences accurately reflects the hormonal cascade leading to ovulation?
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A researcher is investigating the effects of a novel drug on the hypothalamic-pituitary-adrenal (HPA) axis. The drug initially increases ACTH secretion but, after several weeks, ACTH levels return to baseline despite continued drug administration. What is the MOST likely explanation for this phenomenon?
A researcher is investigating the effects of a novel drug on the hypothalamic-pituitary-adrenal (HPA) axis. The drug initially increases ACTH secretion but, after several weeks, ACTH levels return to baseline despite continued drug administration. What is the MOST likely explanation for this phenomenon?
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A long-distance runner experiences secondary amenorrhea (cessation of menstruation) due to intense training. Which hormonal profile is MOST likely contributing to this condition?
A long-distance runner experiences secondary amenorrhea (cessation of menstruation) due to intense training. Which hormonal profile is MOST likely contributing to this condition?
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A researcher is attempting to develop a therapy to enhance sperm maturation. Which of the following approaches, targeting the hormonal regulation of the male reproductive system, would be MOST effective?
A researcher is attempting to develop a therapy to enhance sperm maturation. Which of the following approaches, targeting the hormonal regulation of the male reproductive system, would be MOST effective?
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A patient with a suspected pituitary disorder undergoes dynamic testing. Administration of TRH fails to elicit a TSH response. What is the MOST likely location of the lesion causing this hormonal abnormality?
A patient with a suspected pituitary disorder undergoes dynamic testing. Administration of TRH fails to elicit a TSH response. What is the MOST likely location of the lesion causing this hormonal abnormality?
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A child is diagnosed with idiopathic short stature (ISS) and normal GH levels. However, their IGF-1 levels are significantly below normal. Which of the following interventions is LEAST likely to improve their adult height?
A child is diagnosed with idiopathic short stature (ISS) and normal GH levels. However, their IGF-1 levels are significantly below normal. Which of the following interventions is LEAST likely to improve their adult height?
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Flashcards
Nephron
Nephron
The functional unit of the kidney responsible for urine formation.
Renal Corpuscle
Renal Corpuscle
Structure within the nephron consisting of the glomerulus and Bowman’s capsule.
Glomerulus
Glomerulus
A network of capillaries in the renal corpuscle where blood filtration occurs.
Proximal Convoluted Tubule (PCT)
Proximal Convoluted Tubule (PCT)
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Loop of Henle
Loop of Henle
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Distal Convoluted Tubule (DCT)
Distal Convoluted Tubule (DCT)
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Collecting Duct
Collecting Duct
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Normal Urine Wastes
Normal Urine Wastes
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Adrenal Cortex
Adrenal Cortex
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Zona Glomerulosa
Zona Glomerulosa
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Mineralocorticoids
Mineralocorticoids
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Aldosterone
Aldosterone
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Zona Fasciculata
Zona Fasciculata
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Glucocorticoids
Glucocorticoids
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Cortisol
Cortisol
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Zona Reticularis
Zona Reticularis
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Adrenal Medulla
Adrenal Medulla
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Catecholamines
Catecholamines
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Hypophyseal Portal System
Hypophyseal Portal System
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Thyroid-stimulating Hormone (TSH)
Thyroid-stimulating Hormone (TSH)
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Negative Feedback
Negative Feedback
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Adrenocorticotropic Hormone (ACTH)
Adrenocorticotropic Hormone (ACTH)
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Follicle-stimulating Hormone (FSH)
Follicle-stimulating Hormone (FSH)
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Luteinizing Hormone (LH)
Luteinizing Hormone (LH)
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Prolactin (PRL)
Prolactin (PRL)
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Growth Hormone (GH)
Growth Hormone (GH)
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Regulatory Hormones
Regulatory Hormones
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Gonadotropins
Gonadotropins
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Axon
Axon
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Multipolar Neurons
Multipolar Neurons
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Unipolar Neurons
Unipolar Neurons
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Bipolar Neurons
Bipolar Neurons
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Sensory Neurons
Sensory Neurons
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Motor Neurons
Motor Neurons
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Interneurons
Interneurons
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Somatic Sensory Neurons
Somatic Sensory Neurons
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Visceral Sensory Neurons
Visceral Sensory Neurons
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Visceral Motor Neurons
Visceral Motor Neurons
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Dorsal roots
Dorsal roots
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Ventral roots
Ventral roots
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Gray matter
Gray matter
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White matter
White matter
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Presynaptic neuron
Presynaptic neuron
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Postsynaptic neuron
Postsynaptic neuron
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Autonomic Nervous System (ANS)
Autonomic Nervous System (ANS)
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Study Notes
Renal Structure and Function
- Each kidney contains 1 million nephrons, a functional unit of the kidney.
- Nephrons consist of a renal corpuscle and a renal tubule.
- The renal corpuscle includes the glomerulus and Bowman's capsule.
- Blood arrives at the glomerulus through afferent arterioles and leaves via efferent arterioles.
- The filtration membrane allows water, metabolic wastes, ions, nutrients, and other solutes to enter the capsular space.
- The renal tubule is a long tube where urine formation occurs.
- Urine flows through the following structures: proximal convoluted tubule (PCT), loop of Henle (descending and ascending limbs), distal convoluted tubule (DCT), and collecting duct.
- The DCT is located near afferent and efferent arterioles of the glomerulus.
- The collecting duct makes final adjustments to the composition of urine.
Steps in Urine Formation
- Filtration: The renal corpuscle filters blood to produce a filtrate.
- Reabsorption: Substances needed by the body are reabsorbed from the filtrate back into the blood. This is done in the PCT, loop of Henle, and DCT
- Secretion: Substances not needed or harmful are secreted from the blood into the filtrate.
- Excretion: The urine is expelled from the body.
Normal Waste Products in Urine
- Urea: The most common organic waste, formed during amino acid breakdown.
- Creatinine: Produced in skeletal muscle during creatinine phosphate breakdown
- Uric acid: Formed during ribonucleic acid (RNA) breakdown
Adrenal Glands
- Adrenal glands are yellow, pyramid-shaped, retroperitoneal organs located on top of each kidney.
- They are highly vascularized.
- The adrenal gland is composed of an outer cortex and inner medulla.
Adrenal Cortex
- Zona Glomerulosa: Outermost layer, produces mineralocorticoids (e.g., aldosterone) which regulate electrolyte balance.
- Zona Fasciculata: Forms 78% of cortical volume, produces glucocorticoids (e.g., cortisol), affecting glucose metabolism and having anti-inflammatory properties.
- Zona Reticularis: Narrow band next to the medulla, produces small amounts of androgens (gonadocorticoids).
Adrenal Medulla
- Produces catecholamines: adrenaline (epinephrine) and noradrenaline (norepinephrine).
- These hormones increase cardiac activity, blood pressure, glycogen breakdown, blood glucose levels, and release of lipids by adipose tissue.
Pituitary Gland
- Also called the hypophysis.
- Protected by the sella turcica of the sphenoid bone.
- Attached to the hypothalamus by the infundibulum.
- Divided into the anterior lobe (adenohypophysis) and posterior lobe (neurohypophysis).
- The anterior lobe contains endocrine cells and the posterior lobe contains neurons.
- Regulatory hormones from the hypothalamus are carried to the target cells in the anterior lobe via the hypothalamic-hypophyseal portal system.
Hormones from the Anterior Lobe
- Thyroid-stimulating hormone (TSH): Released in response to TRH (thyrotropin-releasing hormone) to regulate thyroid hormone release.
- Adrenocorticotropic hormone (ACTH): Released in response to CRH(corticotropin-releasing hormone) to regulate glucocorticoid release from the adrenal cortex.
- Gonadotropins (FSH & LH): Released in response to GnRH (gonadotropin-releasing hormone) to regulate reproductive function in males and females.
- Prolactin (PRL): Released in response to PRF (prolactin-releasing factor) to stimulate milk production in females.
- Growth hormone (GH): Regulated by GH-RH (growth hormone-releasing hormone) and GH-IH (growth hormone-inhibiting hormone) stimulating growth and cell replication.
- Melanocyte-stimulating hormone (MSH): Increases melanin production in skin, appears to be non-functional in adults.
Hormones from the Posterior Lobe
- Antidiuretic hormone (ADH): Increases water reabsorption by the kidneys in response to changes in blood volume and solute concentration.
- Oxytocin (OXT): Stimulates uterine muscle contraction during labor and delivery, and milk ejection from mammary glands.
Nervous System: Neuron Structure
- Cell body (soma): Contains a nucleus and other organelles.
- Dendrites: Branching extensions that receive signals from other neurons.
- Axon: A long projection that transmits signals to other neurons, muscles, or glands.
- Axon hillock: Point where signals are generated.
- Axon terminals: End of the axon, release neurotransmitters.
Nervous System: Neuron Classification
- Multipolar Neurons: Most common type, have multiple dendrites and a single axon.
- Unipolar Neurons: Sensory neurons; single process extending from the cell body that divides into two branches.
- Bipolar Neurons: Sensory neurons, found in special sense organs; one axon and one dendrite.
Spinal Cord Structure
- Gray matter: Forms an "H" shape; contains neuron cell bodies, and nerve fibers.
- White matter: Contains bundles of nerve fibers (tracts). These axons are myelinated and transmit signals up and down the spinal cord.
- The gray matter has different projections/regions (horns) that contain different nuclei performing specific roles (Sensory, Somatic Motor, Autonomic Motor nuclei)
- The white matter has different columns (posterior, anterior, lateral white columns) where sensory and motor tracts are located.
Structure of a Synapse
- A synapse is the junction between two neurons.
- It consists of a presynaptic neuron and postsynaptic neuron.
- Neurotransmitters are released across the synaptic cleft.
Autonomic Nervous System
- The ANS regulates involuntary functions, including heart rate, digestion, and blood pressure.
- It has two divisions: the sympathetic and parasympathetic divisions that often have opposite effects.
- The sympathetic division is activated in times of stress and prepares the body for action ("fight-or-flight").
- The parasympathetic division is active during periods of rest and promotes relaxation ("rest-and-digest").
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Description
Explore the structure and function of the renal system, focusing on nephrons, renal corpuscles, and tubules. Understand the process of urine formation, including filtration and reabsorption. Learn about the critical components like the glomerulus, Bowman's capsule, and the loop of Henle.