The Prion Quiz
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Questions and Answers

What is the main cause of prion diseases?

  • Misfolding of PrPSc (correct)
  • Accumulation of PrPSc
  • Inherited genetic mutations
  • Neuronal cell death

How can prions be acquired?

  • Through genetic inheritance
  • Through airborne transmission
  • Through direct contact with infected animals
  • Through feed or food (correct)

Which of the following is a major prion disease affecting wild populations in North America?

  • Scrapie
  • Chronic wasting disease (correct)
  • Bovine spongiform encephalopathy
  • Mink spongiform encephalopathy

What are the clinical signs of prion diseases in animals?

<p>Weight loss, subtle behavioral changes (B)</p> Signup and view all the answers

Which of the following is a zoonotic prion disease?

<p>Bovine spongiform encephalopathy (A)</p> Signup and view all the answers

What is the incubation period for prion diseases in sheep?

<p>2-4 years (B)</p> Signup and view all the answers

Which disease showed a huge increase in cases by 1932, with a peak of 1000 cases per week?

<p>BSE (A)</p> Signup and view all the answers

What were some of the control measures put in place to curb the BSE epidemic?

<p>Culling of animals (D)</p> Signup and view all the answers

Which type of scrapie is mainly seen nowadays?

<p>Atypical scrapie (D)</p> Signup and view all the answers

Which prion disease is a big concern due to its secretion into the environment, making it hard to control?

<p>CWD (D)</p> Signup and view all the answers

Which prion disease has emerged in European cervids, with some cases showing different characteristics than those in America?

<p>CWD (D)</p> Signup and view all the answers

What is the main concern regarding the new strains of CWD and atypical TSE?

<p>Their impact on human health (D)</p> Signup and view all the answers

Which disease poses a threat to UK deer?

<p>CWD (C)</p> Signup and view all the answers

What is a prion and how is it formed?

<p>A prion is a completely novel infectious agent that is formed when the PrPC molecule misfolds into the PrPSc molecule.</p> Signup and view all the answers

What are the main characteristics of prion diseases?

<p>Prion diseases are neurological disorders that result in neuronal loss and are invariably fatal. They have very long incubation periods and can be spontaneously occurring, inherited, or acquired.</p> Signup and view all the answers

Which animals are affected by veterinary prion diseases?

<p>Sheep, goats, mink, deer, elk, cattle, cats, and exotic ungulates are all affected by veterinary prion diseases.</p> Signup and view all the answers

What are the clinical signs of prion diseases in animals?

<p>Clinical signs of prion diseases in animals include weight loss, subtle behavioral changes, licking lips, grinding teeth, scratching, posture and gait abnormalities, ataxia, tremors, and sudden death.</p> Signup and view all the answers

What are the major concerns regarding prion diseases?

<p>The major concerns regarding prion diseases include their zoonotic potential, the difficulty of controlling their spread due to environmental secretion, and the impact on wildlife populations.</p> Signup and view all the answers

What were some of the measures taken by the UK government to reduce cases of classical scrapie?

<p>Selective breeding for resistance</p> Signup and view all the answers

What is the current status of BSE cases in the UK as of 2021?

<p>Fairly few cases seen</p> Signup and view all the answers

What is the main concern regarding the new strains of CWD and atypical TSE in European cervids?

<p>Whether they are zoonotic or not</p> Signup and view all the answers

What are the challenges in controlling scrapie and CWD?

<p>The secretion of prions into the environment</p> Signup and view all the answers

Which disease is mainly seen nowadays in sheep, Atypical scrapie or normal basic scrapie?

<p>Atypical scrapie</p> Signup and view all the answers

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