The Prion Quiz
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Questions and Answers

What is the main cause of prion diseases?

  • Misfolding of PrPSc (correct)
  • Accumulation of PrPSc
  • Inherited genetic mutations
  • Neuronal cell death
  • How can prions be acquired?

  • Through genetic inheritance
  • Through airborne transmission
  • Through direct contact with infected animals
  • Through feed or food (correct)
  • Which of the following is a major prion disease affecting wild populations in North America?

  • Scrapie
  • Chronic wasting disease (correct)
  • Bovine spongiform encephalopathy
  • Mink spongiform encephalopathy
  • What are the clinical signs of prion diseases in animals?

    <p>Weight loss, subtle behavioral changes</p> Signup and view all the answers

    Which of the following is a zoonotic prion disease?

    <p>Bovine spongiform encephalopathy</p> Signup and view all the answers

    What is the incubation period for prion diseases in sheep?

    <p>2-4 years</p> Signup and view all the answers

    Which disease showed a huge increase in cases by 1932, with a peak of 1000 cases per week?

    <p>BSE</p> Signup and view all the answers

    What were some of the control measures put in place to curb the BSE epidemic?

    <p>Culling of animals</p> Signup and view all the answers

    Which type of scrapie is mainly seen nowadays?

    <p>Atypical scrapie</p> Signup and view all the answers

    Which prion disease is a big concern due to its secretion into the environment, making it hard to control?

    <p>CWD</p> Signup and view all the answers

    Which prion disease has emerged in European cervids, with some cases showing different characteristics than those in America?

    <p>CWD</p> Signup and view all the answers

    What is the main concern regarding the new strains of CWD and atypical TSE?

    <p>Their impact on human health</p> Signup and view all the answers

    Which disease poses a threat to UK deer?

    <p>CWD</p> Signup and view all the answers

    What is a prion and how is it formed?

    <p>A prion is a completely novel infectious agent that is formed when the PrPC molecule misfolds into the PrPSc molecule.</p> Signup and view all the answers

    What are the main characteristics of prion diseases?

    <p>Prion diseases are neurological disorders that result in neuronal loss and are invariably fatal. They have very long incubation periods and can be spontaneously occurring, inherited, or acquired.</p> Signup and view all the answers

    Which animals are affected by veterinary prion diseases?

    <p>Sheep, goats, mink, deer, elk, cattle, cats, and exotic ungulates are all affected by veterinary prion diseases.</p> Signup and view all the answers

    What are the clinical signs of prion diseases in animals?

    <p>Clinical signs of prion diseases in animals include weight loss, subtle behavioral changes, licking lips, grinding teeth, scratching, posture and gait abnormalities, ataxia, tremors, and sudden death.</p> Signup and view all the answers

    What are the major concerns regarding prion diseases?

    <p>The major concerns regarding prion diseases include their zoonotic potential, the difficulty of controlling their spread due to environmental secretion, and the impact on wildlife populations.</p> Signup and view all the answers

    What were some of the measures taken by the UK government to reduce cases of classical scrapie?

    <p>Selective breeding for resistance</p> Signup and view all the answers

    What is the current status of BSE cases in the UK as of 2021?

    <p>Fairly few cases seen</p> Signup and view all the answers

    What is the main concern regarding the new strains of CWD and atypical TSE in European cervids?

    <p>Whether they are zoonotic or not</p> Signup and view all the answers

    What are the challenges in controlling scrapie and CWD?

    <p>The secretion of prions into the environment</p> Signup and view all the answers

    Which disease is mainly seen nowadays in sheep, Atypical scrapie or normal basic scrapie?

    <p>Atypical scrapie</p> Signup and view all the answers

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