22 Questions
What is the normal form of the protein involved in prion diseases?
PrPc
Which form of the protein is transmissible via CNS-related tissue or contaminated food?
PrPsc
Why does PrPsc resist protease degradation?
It is in a β-pleated form
How does PrPsc contribute to the progression of prion diseases?
By accumulating and converting more PrPc to PrPsc
Why is PrPsc resistant to standard sterilizing procedures?
It resists protease degradation
What is the characteristic feature of PrPsc that makes it resistant to protease degradation?
Conversion to a β-pleated form
Which neurological symptoms are associated with the accumulation of PrPsc?
Impairment in coordination, balance, and speech
Why is PrPsc not effectively eliminated by standard autoclaving procedures?
It changes the protein's secondary structure
Which disease is specifically mentioned in the text as being associated with cannibalism and having a cerebellar nature?
Kuru
What is the term used to describe sudden, involuntary muscle jerks that are associated with PrPsc accumulation?
Startle myoclonus
Which symptom is NOT associated with adenovirus infections?
Muscle weakness
What is the primary approach used to manage adenoviral infections?
Hydration and symptom management
What kind of vaccines have been developed using adenoviruses?
Adenovirus-vectored vaccines
What poses a significant challenge for researchers studying adenoviruses?
Limited understanding of host-virus interactions
How do adenovirus-vectored vaccines work?
By carrying the genetic material of the target virus
What is a potential outcome of continued research on adenoviruses?
Development of new antiviral therapies and vaccine strategies
What is the shape of viruses within the Adenoviridae family?
Icosahedral
Where do Adenoviruses replicate within the host?
Nucleus
How many distinct serotypes are there within the Adenoviridae family?
67
Which of the following is NOT a type of infection caused by Adenoviruses?
Orthopedic
What is the genetic material found within Adenoviruses?
Double-stranded DNA
Which part of the Adenovirus contains the viral proteins and host cell membrane components?
Envelope
Learn about prion diseases caused by the conversion of normal prion protein to a transmissible form, resulting in spongiform encephalopathy. Understand the resistance of PrPsc to standard sterilizing procedures and its role in facilitating the conversion of more proteins.
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