Prion Diseases
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Questions and Answers

What is the normal form of the protein involved in prion diseases?

  • α-helical form
  • PrPc (correct)
  • PrPsc
  • β-pleated form

    • Which form of the protein is transmissible via CNS-related tissue or contaminated food?

  • PrPsc (correct)
  • PrPc
  • β-pleated form
  • α-helical form

    • Why does PrPsc resist protease degradation?

  • It is in a β-pleated form (correct)
  • It is not affected by proteases
  • It is easier to break down than PrPc
  • It facilitates the conversion of PrPc to PrPsc

    • How does PrPsc contribute to the progression of prion diseases?

    <p>By accumulating and converting more PrPc to PrPsc</p> Signup and view all the answers

    Why is PrPsc resistant to standard sterilizing procedures?

    <p>It resists protease degradation</p> Signup and view all the answers

    What is the characteristic feature of PrPsc that makes it resistant to protease degradation?

    <p>Conversion to a β-pleated form</p> Signup and view all the answers

    Which neurological symptoms are associated with the accumulation of PrPsc?

    <p>Impairment in coordination, balance, and speech</p> Signup and view all the answers

    Why is PrPsc not effectively eliminated by standard autoclaving procedures?

    <p>It changes the protein's secondary structure</p> Signup and view all the answers

    Which disease is specifically mentioned in the text as being associated with cannibalism and having a cerebellar nature?

    <p>Kuru</p> Signup and view all the answers

    What is the term used to describe sudden, involuntary muscle jerks that are associated with PrPsc accumulation?

    <p>Startle myoclonus</p> Signup and view all the answers

    Which symptom is NOT associated with adenovirus infections?

    <p>Muscle weakness</p> Signup and view all the answers

    What is the primary approach used to manage adenoviral infections?

    <p>Hydration and symptom management</p> Signup and view all the answers

    What kind of vaccines have been developed using adenoviruses?

    <p>Adenovirus-vectored vaccines</p> Signup and view all the answers

    What poses a significant challenge for researchers studying adenoviruses?

    <p>Limited understanding of host-virus interactions</p> Signup and view all the answers

    How do adenovirus-vectored vaccines work?

    <p>By carrying the genetic material of the target virus</p> Signup and view all the answers

    What is a potential outcome of continued research on adenoviruses?

    <p>Development of new antiviral therapies and vaccine strategies</p> Signup and view all the answers

    What is the shape of viruses within the Adenoviridae family?

    <p>Icosahedral</p> Signup and view all the answers

    Where do Adenoviruses replicate within the host?

    <p>Nucleus</p> Signup and view all the answers

    How many distinct serotypes are there within the Adenoviridae family?

    <p>67</p> Signup and view all the answers

    Which of the following is NOT a type of infection caused by Adenoviruses?

    <p>Orthopedic</p> Signup and view all the answers

    What is the genetic material found within Adenoviruses?

    <p>Double-stranded DNA</p> Signup and view all the answers

    Which part of the Adenovirus contains the viral proteins and host cell membrane components?

    <p>Envelope</p> Signup and view all the answers

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