Prion Diseases

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Questions and Answers

What is the normal form of the protein involved in prion diseases?

  • α-helical form
  • PrPc (correct)
  • PrPsc
  • β-pleated form

Which form of the protein is transmissible via CNS-related tissue or contaminated food?

  • PrPsc (correct)
  • PrPc
  • β-pleated form
  • α-helical form

Why does PrPsc resist protease degradation?

  • It is in a β-pleated form (correct)
  • It is not affected by proteases
  • It is easier to break down than PrPc
  • It facilitates the conversion of PrPc to PrPsc

How does PrPsc contribute to the progression of prion diseases?

<p>By accumulating and converting more PrPc to PrPsc (A)</p> Signup and view all the answers

Why is PrPsc resistant to standard sterilizing procedures?

<p>It resists protease degradation (B)</p> Signup and view all the answers

What is the characteristic feature of PrPsc that makes it resistant to protease degradation?

<p>Conversion to a β-pleated form (C)</p> Signup and view all the answers

Which neurological symptoms are associated with the accumulation of PrPsc?

<p>Impairment in coordination, balance, and speech (A)</p> Signup and view all the answers

Why is PrPsc not effectively eliminated by standard autoclaving procedures?

<p>It changes the protein's secondary structure (B)</p> Signup and view all the answers

Which disease is specifically mentioned in the text as being associated with cannibalism and having a cerebellar nature?

<p>Kuru (A)</p> Signup and view all the answers

What is the term used to describe sudden, involuntary muscle jerks that are associated with PrPsc accumulation?

<p>Startle myoclonus (C)</p> Signup and view all the answers

Which symptom is NOT associated with adenovirus infections?

<p>Muscle weakness (D)</p> Signup and view all the answers

What is the primary approach used to manage adenoviral infections?

<p>Hydration and symptom management (C)</p> Signup and view all the answers

What kind of vaccines have been developed using adenoviruses?

<p>Adenovirus-vectored vaccines (B)</p> Signup and view all the answers

What poses a significant challenge for researchers studying adenoviruses?

<p>Limited understanding of host-virus interactions (C)</p> Signup and view all the answers

How do adenovirus-vectored vaccines work?

<p>By carrying the genetic material of the target virus (D)</p> Signup and view all the answers

What is a potential outcome of continued research on adenoviruses?

<p>Development of new antiviral therapies and vaccine strategies (D)</p> Signup and view all the answers

What is the shape of viruses within the Adenoviridae family?

<p>Icosahedral (C)</p> Signup and view all the answers

Where do Adenoviruses replicate within the host?

<p>Nucleus (A)</p> Signup and view all the answers

How many distinct serotypes are there within the Adenoviridae family?

<p>67 (C)</p> Signup and view all the answers

Which of the following is NOT a type of infection caused by Adenoviruses?

<p>Orthopedic (B)</p> Signup and view all the answers

What is the genetic material found within Adenoviruses?

<p>Double-stranded DNA (B)</p> Signup and view all the answers

Which part of the Adenovirus contains the viral proteins and host cell membrane components?

<p>Envelope (A)</p> Signup and view all the answers

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