The Ok (024) System: Historical Perspective Quiz
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Questions and Answers

What is the significance of anti-Oka identified in 1979?

  • It was reactive in the pretransfusion testing phase
  • It was named after Mrs. Kobutso's parents
  • It was the first antibody found in the Ok system
  • It caused reduced survival of Ok(a-) RBCs injected into the original antibody maker (correct)
  • Which chromosome harbors the BSG gene responsible for the Ok system antigens?

  • Chromosome 13
  • Chromosome 1
  • Chromosome 19 (correct)
  • Chromosome 24
  • What is the main function of CD147 or basigin in relation to the Ok system?

  • Receptor and adhesion functions (correct)
  • Antibody production stimulation
  • Plasmodium falciparum inhibition
  • Immune response modulation
  • Which high-prevalence antigen of the Ok system is also known as OKGV?

    <p>OKGV or OK2</p> Signup and view all the answers

    What is the clinical significance of Oka being resistant to treatment with ficin, papain, DTT, and glycine-acid EDTA?

    <p>Reduced susceptibility to enzyme treatment</p> Signup and view all the answers

    How many high-prevalence antigens are there in the Ok system?

    <p>3</p> Signup and view all the answers

    What was the outcome when Cr-labeled Ok(a+) RBCs were injected into the original antibody maker?

    <p>Reduced RBC survival rate</p> Signup and view all the answers

    What is the function of BASIGIN in relation to Plasmodium falciparum invasion?

    <p>Receptor essential for invasion</p> Signup and view all the answers

    What is the status of Ok(a-) RBC's among 400 individuals?

    <p>All are Ok(a-)</p> Signup and view all the answers

    What was Mrs. Kobutso's relationship with her parents?

    <p>They were cousins</p> Signup and view all the answers

    Which high-prevalence antigen in the Ok system is carried on CD147, also known as basigin?

    <p>OK1 or Ok(a+, a-)</p> Signup and view all the answers

    Where is the BSG gene, responsible for the Ok system antigens, located?

    <p>Chromosome 19 at position 19p13.3</p> Signup and view all the answers

    What type of antibody was the original anti-Oka?

    <p>IgG</p> Signup and view all the answers

    What is the clinical significance of Ok(a) being resistant to treatment with DTT?

    <p>Decreased RBC survival</p> Signup and view all the answers

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