The Ok (024) System: Historical Perspective Quiz
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Questions and Answers

What is the significance of anti-Oka identified in 1979?

  • It was reactive in the pretransfusion testing phase
  • It was named after Mrs. Kobutso's parents
  • It was the first antibody found in the Ok system
  • It caused reduced survival of Ok(a-) RBCs injected into the original antibody maker (correct)

Which chromosome harbors the BSG gene responsible for the Ok system antigens?

  • Chromosome 13
  • Chromosome 1
  • Chromosome 19 (correct)
  • Chromosome 24

What is the main function of CD147 or basigin in relation to the Ok system?

  • Receptor and adhesion functions (correct)
  • Antibody production stimulation
  • Plasmodium falciparum inhibition
  • Immune response modulation

Which high-prevalence antigen of the Ok system is also known as OKGV?

<p>OKGV or OK2 (A)</p> Signup and view all the answers

What is the clinical significance of Oka being resistant to treatment with ficin, papain, DTT, and glycine-acid EDTA?

<p>Reduced susceptibility to enzyme treatment (A)</p> Signup and view all the answers

How many high-prevalence antigens are there in the Ok system?

<p>3 (B)</p> Signup and view all the answers

What was the outcome when Cr-labeled Ok(a+) RBCs were injected into the original antibody maker?

<p>Reduced RBC survival rate (B)</p> Signup and view all the answers

What is the function of BASIGIN in relation to Plasmodium falciparum invasion?

<p>Receptor essential for invasion (A)</p> Signup and view all the answers

What is the status of Ok(a-) RBC's among 400 individuals?

<p>All are Ok(a-) (C)</p> Signup and view all the answers

What was Mrs. Kobutso's relationship with her parents?

<p>They were cousins (D)</p> Signup and view all the answers

Which high-prevalence antigen in the Ok system is carried on CD147, also known as basigin?

<p>OK1 or Ok(a+, a-) (B)</p> Signup and view all the answers

Where is the BSG gene, responsible for the Ok system antigens, located?

<p>Chromosome 19 at position 19p13.3 (C)</p> Signup and view all the answers

What type of antibody was the original anti-Oka?

<p>IgG (C)</p> Signup and view all the answers

What is the clinical significance of Ok(a) being resistant to treatment with DTT?

<p>Decreased RBC survival (C)</p> Signup and view all the answers

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