The Impact of Semaglutide on Alcohol Relapse

Semaglutide reduced alcohol relapse drinking and alcohol intake in rats by over 50% and the effect persisted in relapse. Relapse in individuals with alcohol dependence means persons often drink more than before their withdrawal. Semaglutide blocks alchohol-induced dopamine ______ in the nucleus accumbens, which participates in the brain’s reward system.

Guideline-recommended quadruple ______ in heart failure is only “borderline cost effective” vs adding an SGLT-2 inhibitor alone to the previous standard of care. The latest guidance from the AHA, ACC, and Heart Failure Society of America recommends quadruple ______ with an angiotensin receptor-neprilysin inhibitor (ARNi), SGLT-2 inhibitor, mineralocorticoid receptor antagonist (MRA), and beta-blocker. A two-week course of metformin given within three days of testing positive for COVID-19 resulted in 40% fewer long covid diagnoses over the following 10 months vs placebo. The anti-obesity medication orlistat can cause steatorrhea and patients on this drug for an extended period are advised to take a multivitamin at bedtime. Tirzepatide effects weight loss through dual actions on appetite hormones.

A two-week course of metformin given within three days of testing positive for COVID-19 resulted in 40% fewer long covid diagnoses over the following 10 months vs placebo. The anti-obesity medication orlistat can cause steatorrhea and patients on this drug for an extended period are advised to take a multivitamin at bedtime. Tirzepatide effects weight loss through dual actions on ______ hormones.