The Impact of PTH on Bone Health

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Questions and Answers

Which population is the most robust clinical data available for management of osteoporosis?

  • Postmenopausal women (correct)
  • Younger women
  • Men
  • Special populations

What is the recommended evaluation for all patients presenting with osteoporosis?

  • Bone mineral density (BMD) only
  • Fracture history only
  • FRAX tool only
  • Fracture history, BMD, and FRAX tool (correct)

How long may osteoporosis therapy last?

  • 5-10 years
  • More than 10 years
  • Not well defined (correct)
  • Less than 5 years

According to the text, which type of osteoporotic fracture is most likely to be asymptomatic and undetected?

<p>Vertebral fracture (A)</p> Signup and view all the answers

Based on the text, which of the following is NOT a bone healthy lifestyle intervention?

<p>Smoking and excessive alcohol intake (B)</p> Signup and view all the answers

According to the text, what is the range of T-score for osteopenia/low BMD?

<p>T-score between -1.0 and -2.5 (C)</p> Signup and view all the answers

Which demographic group is the 10-year fracture risk validated for?

<p>Postmenopausal women to age 90 (A)</p> Signup and view all the answers

Which calcium salt is the most commonly used?

<p>Calcium carbonate (A)</p> Signup and view all the answers

What is the recommended serum level of Vitamin D for treatment?

<p>Greater than 30 ng/mL (D)</p> Signup and view all the answers

Which bisphosphonate is typically a first line treatment option?

<p>Alendronate (Fosamax) (A)</p> Signup and view all the answers

Which drug stimulates bone resorption and is approved for use for only 2 years?

<p>Teriparatide (D)</p> Signup and view all the answers

Which hormone inhibits the production of active vitamin D and phosphate reabsorption?

<p>FGF23 (D)</p> Signup and view all the answers

Which enzyme adds a hydroxyl group to the 25th carbon of vitamin D in the liver?

<p>25-hydroxylase (D)</p> Signup and view all the answers

Which hormone stimulates the production of FGF23?

<p>Vitamin D (B)</p> Signup and view all the answers

Which of the following is a characteristic of osteoporosis?

<p>Low bone mass (A)</p> Signup and view all the answers

What is the recommended approach when anabolic therapy is indicated?

<p>Start anabolic therapy first, then antiresorptive therapy (B)</p> Signup and view all the answers

Which of the following is a risk factor for osteoporosis?

<p>Late menopause in women (A)</p> Signup and view all the answers

What is the primary role of osteoclasts in bone metabolism?

<p>Increase bone resorption (B)</p> Signup and view all the answers

Which of the following medications is NOT approved for prevention pharmacotherapy for osteoporosis?

<p>Teriparatide (C)</p> Signup and view all the answers

What is the recommended first-line selection for pharmacotherapy to treat osteoporosis?

<p>Bisphosphonates (D)</p> Signup and view all the answers

Who is eligible for pharmacotherapy to prevent osteoporosis?

<p>Postmenopausal women with a T-score between -1 and -2.5 plus high fracture risk (A)</p> Signup and view all the answers

What is the expected duration and outcome of osteoporosis treatment?

<p>Prevention of progression to osteoporosis and/or first fracture (B)</p> Signup and view all the answers

Which generation of bisphosphonates is the most potent?

<p>3rd gen (D)</p> Signup and view all the answers

Which bisphosphonate is administered orally once daily or weekly?

<p>Risedronate (C)</p> Signup and view all the answers

What is the mechanism of action of bisphosphonates?

<p>Decrease osteoclastic bone resorption (C)</p> Signup and view all the answers

What are the contraindications for bisphosphonate use?

<p>All of the above (D)</p> Signup and view all the answers

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OsteoporosisQG.docx

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