The Impact of PTH on Bone Health
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Questions and Answers

Which population is the most robust clinical data available for management of osteoporosis?

  • Postmenopausal women (correct)
  • Younger women
  • Men
  • Special populations
  • What is the recommended evaluation for all patients presenting with osteoporosis?

  • Bone mineral density (BMD) only
  • Fracture history only
  • FRAX tool only
  • Fracture history, BMD, and FRAX tool (correct)
  • How long may osteoporosis therapy last?

  • 5-10 years
  • More than 10 years
  • Not well defined (correct)
  • Less than 5 years
  • According to the text, which type of osteoporotic fracture is most likely to be asymptomatic and undetected?

    <p>Vertebral fracture</p> Signup and view all the answers

    Based on the text, which of the following is NOT a bone healthy lifestyle intervention?

    <p>Smoking and excessive alcohol intake</p> Signup and view all the answers

    According to the text, what is the range of T-score for osteopenia/low BMD?

    <p>T-score between -1.0 and -2.5</p> Signup and view all the answers

    Which demographic group is the 10-year fracture risk validated for?

    <p>Postmenopausal women to age 90</p> Signup and view all the answers

    Which calcium salt is the most commonly used?

    <p>Calcium carbonate</p> Signup and view all the answers

    What is the recommended serum level of Vitamin D for treatment?

    <p>Greater than 30 ng/mL</p> Signup and view all the answers

    Which bisphosphonate is typically a first line treatment option?

    <p>Alendronate (Fosamax)</p> Signup and view all the answers

    Which drug stimulates bone resorption and is approved for use for only 2 years?

    <p>Teriparatide</p> Signup and view all the answers

    Which hormone inhibits the production of active vitamin D and phosphate reabsorption?

    <p>FGF23</p> Signup and view all the answers

    Which enzyme adds a hydroxyl group to the 25th carbon of vitamin D in the liver?

    <p>25-hydroxylase</p> Signup and view all the answers

    Which hormone stimulates the production of FGF23?

    <p>Vitamin D</p> Signup and view all the answers

    Which of the following is a characteristic of osteoporosis?

    <p>Low bone mass</p> Signup and view all the answers

    What is the recommended approach when anabolic therapy is indicated?

    <p>Start anabolic therapy first, then antiresorptive therapy</p> Signup and view all the answers

    Which of the following is a risk factor for osteoporosis?

    <p>Late menopause in women</p> Signup and view all the answers

    What is the primary role of osteoclasts in bone metabolism?

    <p>Increase bone resorption</p> Signup and view all the answers

    Which of the following medications is NOT approved for prevention pharmacotherapy for osteoporosis?

    <p>Teriparatide</p> Signup and view all the answers

    What is the recommended first-line selection for pharmacotherapy to treat osteoporosis?

    <p>Bisphosphonates</p> Signup and view all the answers

    Who is eligible for pharmacotherapy to prevent osteoporosis?

    <p>Postmenopausal women with a T-score between -1 and -2.5 plus high fracture risk</p> Signup and view all the answers

    What is the expected duration and outcome of osteoporosis treatment?

    <p>Prevention of progression to osteoporosis and/or first fracture</p> Signup and view all the answers

    Which generation of bisphosphonates is the most potent?

    <p>3rd gen</p> Signup and view all the answers

    Which bisphosphonate is administered orally once daily or weekly?

    <p>Risedronate</p> Signup and view all the answers

    What is the mechanism of action of bisphosphonates?

    <p>Decrease osteoclastic bone resorption</p> Signup and view all the answers

    What are the contraindications for bisphosphonate use?

    <p>All of the above</p> Signup and view all the answers

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