The Immune System Organs and Cells Quiz

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26 Questions

Which cells play a central role in the activation of B cells, Tc cells, and a variety of other cells that participate in the immune response?

T-helper cells

Which cells constitute 5%-10% of peripheral blood lymphocytes and attack pathogens and abnormal cells?

Natural Killer (NK) cells

What type of response activates mainly T cytotoxic cells and macrophages?

TH1 response

Which type of cells lack surface markers or membrane associated proteins from B or T lymphocytes and lack immunologic specificity and memory?

Null cells

Which cells are part of the innate immune system, replenish resident macrophages and dendritic cells, and function in both innate and adaptive immunity?

Monocytes

Which cells are specialized phagocytic cells that stimulate lymphocytes and other immune cells to respond to pathogens?

Macrophages

Which type of immune cells move by amoeboid movement in the tissues as a hallmark of chronic inflammation?

Macrophages

Which type of response activates mainly B cells?

TH2 response

Which cells are the predominant cells in pus, accounting for its whitish/yellowish appearance?

Neutrophils

Which cell type is involved in combating multicellular parasites and certain infections?

Eosinophils

Which group of cells do not have antigen-specific receptors and assist other cells in the immune response?

Macrophages

Which cell is named based on its tissue location in the brain?

Microglial cell

Which leukocyte constitutes 50%-70% of circulating white blood cells?

Neutrophil

Which leukocyte is not involved in phagocytosis?

Basophil

What is the primary function of the lymphoid organs in the body?

To provide the products of immunity

Which cell type is not part of the primary and secondary antibody response?

Granulocyte

Which leukocyte is found in the liver?

Kupffer cell

Which leukocyte is classified as an antigen-presenting cell?

Macrophage

Which cells constitute 20%-40% of the body's white blood cells?

Lymphocytes

What are the three populations of lymphocytes based on function and cell-membrane components?

B cells, T cells, NK cells

Which cells serve as the effector cells for the B cell lineage?

Plasma cells

What do some of the progeny of B and T lymphoblast differentiate into?

Memory cells

What is responsible for the life-long immunity observed for many pathogens?

Persistence of memory cells

What is the CD nomenclature originally developed for?

Human leukocyte molecules

What is a common use of monoclonal Abs that react with a particular membrane molecule?

Cluster of differentiation (CD) grouping

What do the lymphoid organs provide to support the immune system?

$Molecules of immunity

Study Notes

Immune Response Cells

  • Dendritic cells play a central role in the activation of B cells, Tc cells, and other cells that participate in the immune response.

Lymphocytes

  • T cells and B cells constitute 5%-10% of peripheral blood lymphocytes and attack pathogens and abnormal cells.
  • T cells are involved in cell-mediated immune response, which activates mainly T cytotoxic cells and macrophages.
  • B cells are involved in humoral immune response, which activates mainly B cells.

Cell Characteristics

  • Natural Killer (NK) cells lack surface markers or membrane-associated proteins from B or T lymphocytes and lack immunologic specificity and memory.
  • Monocytes are part of the innate immune system, replenish resident macrophages and dendritic cells, and function in both innate and adaptive immunity.
  • Dendritic cells are specialized phagocytic cells that stimulate lymphocytes and other immune cells to respond to pathogens.

Cell Movement and Inflammation

  • Eosinophils move by amoeboid movement in the tissues as a hallmark of chronic inflammation.

Cell Populations

  • Neutrophils are the predominant cells in pus, accounting for its whitish/yellowish appearance.
  • Eosinophils are involved in combating multicellular parasites and certain infections.
  • Macrophages and dendritic cells do not have antigen-specific receptors and assist other cells in the immune response.

Cell Locations

  • Microglia are named based on their tissue location in the brain.
  • Neutrophils constitute 50%-70% of circulating white blood cells.
  • Lymphocytes are not involved in phagocytosis.

Leukocytes

  • Kupffer cells are found in the liver and are involved in phagocytosis.
  • Dendritic cells are classified as antigen-presenting cells.

Lymphoid Organs

  • The primary function of the lymphoid organs in the body is to support the immune system by providing a site for lymphocyte development, activation, and proliferation.
  • Lymphoid organs provide a site for immune cell activation, proliferation, and differentiation.

Lymphocyte Functions

  • There are three populations of lymphocytes based on function and cell-membrane components: B cells, T cells, and NK cells.
  • Plasma cells serve as the effector cells for the B cell lineage.
  • Some progeny of B and T lymphoblasts differentiate into memory cells.

Immune Response

  • Memory cells are responsible for the life-long immunity observed for many pathogens.
  • The CD nomenclature was originally developed for leukocyte surface molecules.
  • Monoclonal Abs that react with a particular membrane molecule are commonly used to identify and isolate specific cell populations.
  • Lymphoid organs provide a site for immune cell activation, proliferation, and differentiation.

Test your knowledge about the primary and secondary lymphoid organs, such as bone marrow, thymus, lymph nodes, spleen, adenoids, tonsils, Peyer's patches, and mucosal associated lymphoid tissue (MALT). Learn about the central cells of the immune system - lymphocytes, and their subdivisions.

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