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Questions and Answers
What is one of the criteria that scientists must follow when designing their experiments?
What is one of the criteria that scientists must follow when designing their experiments?
What type of data must a scientific experiment use?
What type of data must a scientific experiment use?
What is an essential component that a house must have, analogous to a requirement in scientific experiments?
What is an essential component that a house must have, analogous to a requirement in scientific experiments?
Why is it important for scientists to follow certain rules when designing their experiments?
Why is it important for scientists to follow certain rules when designing their experiments?
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What is the primary purpose of a scientific experiment?
What is the primary purpose of a scientific experiment?
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What were Oswald Avery's objective results for the experiment?
What were Oswald Avery's objective results for the experiment?
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How did Avery confirm that DNA was the transforming principle?
How did Avery confirm that DNA was the transforming principle?
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What did Avery's experiment demonstrate about the transforming principle?
What did Avery's experiment demonstrate about the transforming principle?
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How did Avery rule out the presence of RNA in the transforming principle?
How did Avery rule out the presence of RNA in the transforming principle?
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What did Avery observe to determine whether transformation occurred?
What did Avery observe to determine whether transformation occurred?
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What did Frederick Griffith conclude from his experiment with pneumococcus bacteria?
What did Frederick Griffith conclude from his experiment with pneumococcus bacteria?
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What did Oswald Avery and his colleagues discover to be the transforming principle?
What did Oswald Avery and his colleagues discover to be the transforming principle?
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What did Avery rule out as the transforming principle before identifying nucleic acids?
What did Avery rule out as the transforming principle before identifying nucleic acids?
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What was the outcome of mixing live R cells with lysate from dead S cells in Avery's experiment?
What was the outcome of mixing live R cells with lysate from dead S cells in Avery's experiment?
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What did Griffith observe when he mixed living R cells with dead S cells?
What did Griffith observe when he mixed living R cells with dead S cells?
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Study Notes
The Griffith Experiment: Discovering the Transforming Principle
- Frederick Griffith studied two strains of pneumococcus bacteria: S (smooth) and R (rough)
- Mice injected with S bacteria died, while those injected with R bacteria survived
- Griffith discovered that mixing living R cells with dead S cells caused the mice to die
- Griffith concluded that a transforming principle was responsible for the change in the R bacteria
- Oswald Avery continued Griffith's work to identify the transforming principle
- Avery's list of candidates for the transforming principle included the sugar coat, proteins, and nucleic acids
- Avery designed an experiment to test each factor separately and control for multiple variables
- He mixed live R cells with lysate from dead S cells and found that the mixture yielded live S cells
- Avery then tested whether the sugar coat or proteins were the transforming principle, but both were ruled out
- Nucleic acids in the lysate were isolated and found to contain the transforming principle
- Avery and his colleagues precipitated the nucleic acids, mixed them with water, and tested them for the transforming ability
- The nucleic acids were confirmed to be the transforming principle, leading to the discovery that DNA is the genetic molecule
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Description
Test your knowledge of the Griffith Experiment and the discovery of the transforming principle with this quiz. Learn about Frederick Griffith's groundbreaking research on pneumococcus bacteria and how Oswald Avery continued the work to identify DNA as the genetic molecule.