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The Genetic Factors of Autoimmune Diseases

10 Questions

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The Genetic Factors of Autoimmune Diseases

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Questions and Answers

Which type of twins are more likely to develop the same autoimmune disease if one twin already has it?

Fraternal twins

Identical twins (correct)

Unrelated twins

Triplets

What is the main contribution to the inherited risk of most autoimmune diseases?

Environmental factors

Multiple gene loci (correct)

Polymorphisms

HLA alleles

What is the likelihood of a particular autoimmune disease in people with versus without a particular HLA allele expressed as?

Protection ratio

Relative risk

Predisposition ratio

Odds ratio (correct)

Which of the following is true about the association between HLA alleles and autoimmune diseases?

HLA alleles increase the risk of developing autoimmune diseases. Signup and view all the answers

Which class of HLA alleles are most commonly associated with autoimmune diseases?

Class II HLA alleles Signup and view all the answers

What is the role of MHC molecules in autoimmune diseases?

MHC molecules control the action of CD4+ T cells. Signup and view all the answers

What is the cause of autoimmune diseases?

Environmental triggers Signup and view all the answers

Which of the following is true about the HLA-B27 allele and ankylosing spondylitis?

The risk of developing ankylosing spondylitis is 90 to 100 times higher in people with the HLA-B27 allele compared to those without it. Signup and view all the answers

Which of the following is true about HLA alleles and diseases?

Different HLA alleles are associated with different diseases. Signup and view all the answers

Which methods are used to identify HLA alleles?

Molecular (DNA-based) typing and serologic (antibody-based) methods. Signup and view all the answers