The Genetic Factors of Autoimmune Diseases

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Questions and Answers

Which type of twins are more likely to develop the same autoimmune disease if one twin already has it?

  • Fraternal twins
  • Identical twins (correct)
  • Unrelated twins
  • Triplets

What is the main contribution to the inherited risk of most autoimmune diseases?

  • Environmental factors
  • Multiple gene loci (correct)
  • Polymorphisms
  • HLA alleles

What is the likelihood of a particular autoimmune disease in people with versus without a particular HLA allele expressed as?

  • Protection ratio
  • Relative risk
  • Predisposition ratio
  • Odds ratio (correct)

Which of the following is true about the association between HLA alleles and autoimmune diseases?

<p>HLA alleles increase the risk of developing autoimmune diseases. (B)</p> Signup and view all the answers

Which class of HLA alleles are most commonly associated with autoimmune diseases?

<p>Class II HLA alleles (B)</p> Signup and view all the answers

What is the role of MHC molecules in autoimmune diseases?

<p>MHC molecules control the action of CD4+ T cells. (D)</p> Signup and view all the answers

What is the cause of autoimmune diseases?

<p>Environmental triggers (C)</p> Signup and view all the answers

Which of the following is true about the HLA-B27 allele and ankylosing spondylitis?

<p>The risk of developing ankylosing spondylitis is 90 to 100 times higher in people with the HLA-B27 allele compared to those without it. (C)</p> Signup and view all the answers

Which of the following is true about HLA alleles and diseases?

<p>Different HLA alleles are associated with different diseases. (A)</p> Signup and view all the answers

Which methods are used to identify HLA alleles?

<p>Molecular (DNA-based) typing and serologic (antibody-based) methods. (A)</p> Signup and view all the answers

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