The Cell Cycle and Regulation

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Questions and Answers

What is the process of separating chromosomes into two identical sets called?

  • Interphase
  • Mitosis (correct)
  • DNA replication
  • Cytokinesis

What are the two main phases of the cell cycle in eukaryotic cells?

  • Interphase and cytokinesis
  • Interphase and mitotic phase (correct)
  • G1 and S
  • S and G2

What happens during S phase of interphase?

  • Separation of chromosomes into two identical sets
  • DNA replication (correct)
  • Mitotic spindle assembly
  • Separation of all cell components

What is the quiescent state called that cells can enter?

<p>G0 (C)</p> Signup and view all the answers

What can errors in mitosis cause?

<p>Mutations that lead to cancer (A)</p> Signup and view all the answers

What are cyclins and cyclin-dependent kinases (CDKs)?

<p>Key regulatory molecules that determine a cell's progress through the cell cycle (A)</p> Signup and view all the answers

What is the first cyclin produced in cells that enter the cell cycle in response to extracellular signals?

<p>Cyclin D (C)</p> Signup and view all the answers

What is the role of checkpoint regulation in an organism's development and sexual reproduction?

<p>It prevents cell cycle progression until necessary phase processes are completed and DNA damage is repaired (D)</p> Signup and view all the answers

What is the fluorescent ubiquitination-based cell cycle indicator (FUCCI) used for?

<p>Imaging the cell cycle (B)</p> Signup and view all the answers

What is the accurate process for repairing DNA double-strand breaks?

<p>Homologous recombination (A)</p> Signup and view all the answers

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Study Notes

  • The cell cycle is a series of events that cause a cell to divide into two daughter cells.
  • In eukaryotic cells, the cell cycle is divided into interphase and the mitotic phase.
  • Interphase is divided into G1, S, and G2 phases.
  • During S phase, DNA replication occurs.
  • Mitotic phase consists of mitosis and cytokinesis.
  • Mitosis is the process of separating chromosomes into two identical sets.
  • Cytokinesis is the separation of all cell components.
  • The cell cycle is regulated by cell cycle checkpoints.
  • Cells can enter a quiescent state called G0.
  • Errors in mitosis can cause mutations that lead to cancer.
  • Regulation of the cell cycle is crucial for cell survival and involves detection and repair of genetic damage and prevention of uncontrolled cell division.
  • Cyclins and cyclin-dependent kinases (CDKs) are key regulatory molecules that determine a cell's progress through the cell cycle.
  • Cyclins form regulatory subunits and CDKs form catalytic subunits of an activated heterodimer.
  • Different cyclin-CDK combinations determine the downstream proteins targeted.
  • Cyclin D is the first cyclin produced in cells that enter the cell cycle in response to extracellular signals.
  • Cyclin D-CDK4/6 complexes mono-phosphorylate the retinoblastoma susceptibility protein (Rb) to pRb, which induces G1/S cell cycle gene expression and progression into S phase.
  • Hyperphosphorylated Rb dissociates from the E2F/DP1/Rb complex, activating E2F and resulting in transcription of various genes.
  • Cyclin E produced binds to CDK2, forming the cyclin E-CDK2 complex, which pushes the cell from G1 to S phase.
  • Mitotic cyclin-CDK complexes promote the initiation of mitosis by stimulating downstream proteins involved in chromosome condensation and mitotic spindle assembly.
  • G1 cyclin-CDK activities primarily tune the timing rather than the commitment of cell cycle entry.
  • The cell cycle is regulated by cyclin-dependent kinases (CDKs) and cyclins.
  • CDKs are activated by binding to cyclins and phosphorylate target proteins.
  • The progression of the cell cycle is regulated by inhibitors such as the cip/kip and INK4a/ARF families.
  • Synthetic inhibitors of Cdc25 can be used as antineoplastic and anticancer agents.
  • Cdk4/6 inhibitors have been developed as a therapeutic target for anti-tumor effectiveness.
  • A semi-autonomous transcriptional network works with the CDK-cyclin machinery to regulate the cell cycle.
  • Cell cycle checkpoints prevent cell cycle progression until necessary phase processes are completed and DNA damage is repaired.
  • Checkpoints include the G1/S checkpoint, G2/M checkpoint, and metaphase checkpoint.
  • Mutations that allow cells to speed through checkpoints or skip them altogether can lead to cancer.
  • Loss of Rb can lead to primary resistance to Cdk4/6 inhibitors.
  • Cells can leave the cell cycle and stay in G0 until their death, removing the need for cellular checkpoints.
  • Checkpoint regulation plays an important role in an organism's development and sexual reproduction.
  • p53 plays a crucial role in triggering control mechanisms at both G1/S and G2/M checkpoints.
  • Fluorescence imaging of the cell cycle is possible with the fluorescent ubiquitination-based cell cycle indicator (FUCCI).
  • A disregulation of the cell cycle components may lead to tumor formation.
  • The proportion of cells in active cell division in tumors is much higher than in normal tissue.
  • The cells actively undergoing cell cycle are targeted in cancer therapy.
  • The fastest cycling mammalian cells in culture have a cycle time as short as 9 to 10 hours.
  • Cells are most radiosensitive in late M and G2 phases and most resistant in late S phase.
  • Homologous recombination is an accurate process for repairing DNA double-strand breaks.

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