Principles of Antimicrobial Therapy

What is a major determinant of a drug's ability to penetrate the blood–brain barrier?

Which of the following tissues has a natural barrier to drug delivery?

What is the primary characteristic of drugs that are able to penetrate the blood–brain barrier?

Which of the following antibiotics has limited penetration through the intact blood–brain barrier?

What is the primary function of the tight junctions in the capillaries of the brain?

What is the factor that influences the penetration and concentration of an antibacterial agent in the CSF?

Which of the following antibiotics should be used with caution in patients with liver dysfunction?

What is a consequence of poor perfusion in the lower limbs of a diabetic patient?

Why should neonates be treated with caution when using antibiotics such as chloramphenicol and sulfonamides?

Why should young children not be treated with tetracyclines?

What should prescribers consult when considering the use of an antibiotic in pregnant or lactating patients?

Why may elderly patients require special consideration when using certain antibiotics?

What is a potential concern when administering antibiotics to pregnant women?

Which of the following is a risk factor for infection with multidrug-resistant pathogens?

Why are penicillins considered to be relatively safe?

What is a consideration when selecting an antimicrobial agent for a patient?

Which of the following antibiotics should be avoided during pregnancy?

Why are some antimicrobial agents reserved for life-threatening infections?

What is an important factor to consider in addition to the site of infection and severity of the illness when choosing an antimicrobial agent?

Why is parenteral administration of antimicrobial agents used in some cases?

What is a benefit of switching patients from IV to oral therapy when clinically stable?

What is an important consideration when selecting an antimicrobial agent for a patient?

What is a reason why vancomycin, clindamycin, daptomycin, and linezolid may be considered for the treatment of MRSA?

Why is the oral route of administration preferred for mild infections?

Which antibiotic exhibits a concentration-dependent killing effect?

What best predicts the clinical efficacy of β-lactams and glycopeptides?

What is the effect of extended or continuous infusions of certain drugs?

Which of the following drugs works best by optimizing the ratio of the 24-hour area under the concentration–time curve to MIC?

What is the significance of the MIC in the context of antimicrobial therapy?

What is the term used to describe the effect of certain antimicrobials where the clinical efficacy is best predicted by the percentage of time that blood concentrations of a drug remain above the MIC?

What is the primary concern in restricting the prophylactic use of antimicrobial agents?

What is a common complication of antibiotic therapy that can lead to secondary infections?

What is the result of antibiotic therapy that can lead to alterations in the normal microbial flora?

What is the primary mechanism of ototoxicity caused by aminoglycosides?

What is the term used to describe the serious hypersensitivity reactions that can occur with antibiotic therapy?

What is the primary consideration in determining the duration of prophylactic antibiotic therapy?

What is the result of antibiotic therapy that can lead to the growth of resistant bacteria?

What is the primary reason for restricting the use of prophylactic antibiotics to specific clinical situations?

What is the common consequence of antibiotic therapy that can lead to secondary infections?

What is the primary mechanism of antibiotic-associated hypersensitivity reactions?