Th17 Cells and Cytokines in Leprosy: Immune Response Review

Conflicting data exist concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, with higher levels being more evident in the tuberculoid clinical form of leprosy and type 1 reactions.

Th17 cells and their cytokines play a crucial role in leprosy, with cytokines such as IL-1β and IL-23 inducing Th17, while transforming growth factor beta and IL-10 inhibiting Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization.

The conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls indicate that more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.

<p>Cytokines such as IL-1β and IL-23 are important in leprosy as they induce Th17 cells, which play a crucial role in the disease.</p> Signup and view all the answers

<p>The balance between Th17 and regulatory T cells is crucial for leprosy polarization.</p> Signup and view all the answers

<p>IL-1β and IL-23</p> Signup and view all the answers

<p>Transforming growth factor beta and IL-10</p> Signup and view all the answers

<p>Tuberculoid clinical form</p> Signup and view all the answers

<p>Th17 cells</p> Signup and view all the answers

<p>Type 1 reactions</p> Signup and view all the answers

<p>Regulating the balance between Th17 and regulatory T cells</p> Signup and view all the answers

<p>The balance between Th17 and regulatory T cells</p> Signup and view all the answers

<p>Transforming growth factor beta</p> Signup and view all the answers

<p>Inducing Th17 cell development</p> Signup and view all the answers

<p>IL-23 and IL-1β</p> Signup and view all the answers