15 Questions
What are the conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls?
Conflicting data exist concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, with higher levels being more evident in the tuberculoid clinical form of leprosy and type 1 reactions.
What is the role of Th17 cells and their cytokines in leprosy?
Th17 cells and their cytokines play a crucial role in leprosy, with cytokines such as IL-1β and IL-23 inducing Th17, while transforming growth factor beta and IL-10 inhibiting Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization.
What is indicated by the conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls?
The conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls indicate that more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.
Why are cytokines such as IL-1β and IL-23 important in leprosy?
Cytokines such as IL-1β and IL-23 are important in leprosy as they induce Th17 cells, which play a crucial role in the disease.
What is crucial for leprosy polarization?
The balance between Th17 and regulatory T cells is crucial for leprosy polarization.
Which cytokines induce the formation of Th17 cells?
IL-1β and IL-23
What inhibits the formation of Th17 cells in leprosy?
Transforming growth factor beta and IL-10
In which clinical form of leprosy have higher levels of interleukin (IL)-17 been more evident?
Tuberculoid clinical form
What is crucial for leprosy polarization according to the review?
Th17 cells
What type of reactions have shown higher levels of interleukin (IL)-17 in patients with leprosy?
Type 1 reactions
What is the role of Th17 cells and their cytokines in leprosy?
Regulating the balance between Th17 and regulatory T cells
What is crucial for leprosy polarization according to the review?
The balance between Th17 and regulatory T cells
What inhibits the formation of Th17 cells in leprosy?
Transforming growth factor beta
What are cytokines such as IL-1β and IL-23 important for in leprosy?
Inducing Th17 cell development
Which cytokines induce the formation of Th17 cells?
IL-23 and IL-1β
Explore the role of Th17 cells and cytokines in leprosy, and understand the immune response and polarization in this review article published in the Revista da Sociedade Brasileira de Medicina Tropical (Journal of the Brazilian Society of Tropical Medicine).
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