Testosterone Synthesis and Related Hormones
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Questions and Answers

Which enzyme catalyzes the irreversible conversion of testosterone to dihydrotestosterone (DHT)?

  • 17β-HSD
  • Cytochrome P450
  • 5 α-reductase (correct)
  • Aromatase
  • In adult males, the plasma concentration of DHT is approximately what fraction of the testosterone concentration?

  • One-tenth (correct)
  • One-hundredth
  • One-fifth
  • One-third
  • Which tissues have receptors sensitive to DHT rather than testosterone?

  • Spermatogonia and bone
  • Prostate and external genitalia (correct)
  • Brain and kidney
  • Muscle and skin
  • What type of reaction converts pregnenolone to testosterone, apart from those catalyzed by 17β-HSD?

    <p>Irreversible reactions</p> Signup and view all the answers

    Where does the synthesis of testosterone from pregnenolone primarily occur?

    <p>Smooth endoplasmic reticulum</p> Signup and view all the answers

    From which hormone is estradiol (E2) primarily produced in small amounts?

    <p>Testosterone</p> Signup and view all the answers

    Study Notes

    Testosterone Synthesis

    • Reactions involved in testosterone synthesis from pregnenolone are irreversible, except for those catalyzed by the 17β-OHSD enzyme.
    • These reactions occur in the smooth endoplasmic reticulum.

    Dihydrotestosterone (DHT)

    • Produced from testosterone in an irreversible reaction catalyzed by NADPH-dependent 5α-reductase enzyme.
    • Mainly produced in extratesticular tissue and to a lesser extent in the testes.
    • Plasma concentration of DHT in adult males is about one-tenth that of testosterone.
    • Testosterone is considered a prohormone since it's converted into the more potent DHT.
    • Some receptors in the body are sensitive to testosterone (spermatogonia, brain, kidney, muscle, and bone), while others are sensitive to DHT (prostate, external genitalia, and genital skin).

    Estradiol (E2)

    • Produced in small amounts mainly from testosterone.

    Anti-Mullerian Hormone (AMH)

    • Produced by the Sertoli cells of the testes.
    • Production starts in males during early embryonic life.

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    Description

    This quiz covers the reactions involved in testosterone synthesis from pregnenolone, including the role of 17β-OHSD enzyme, and the production of dihydrotestosterone (DHT) from testosterone. It also touches on the plasma concentration of DHT and its production sites.

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