Testicular Anatomy and Tumors

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What is the major function of Sertoli cells?

Involved in lymphatic spread of testicular tumors

Located in interstitial tissue

Derived from 2 or 3 germ layers

Initiate spermatogenesis (correct)

Which layer of the testes forms the vascular layer?

Tunica vasculosa (correct)

Tunica vaginalis

Tunica of interstitial tissue

Tunica albuginea

What is the most common solid tumor in males aged 15-35?

Yolk sac tumor

Seminoma (correct)

Spermatocytic seminoma

Teratoma

Which nodes are NOT involved in the lymphatic spread of testicular tumors?

Inguinal nodes Signup and view all the answers

What is classical seminoma known to be?

Bilateral germ cell tumor Signup and view all the answers

Which of the following is a common risk factor for testicular germ cell tumors?

Family history Signup and view all the answers

What does an elevated AFP suggest in a testicular tumor?

Presence of yolk sac tumor components Signup and view all the answers

Where is intratubular germ cell neoplasia (ITGCN) commonly found?

Within the seminiferous epithelium Signup and view all the answers

What is one of the key factors affecting the prognosis of testicular tumors?

Histologic type and tumor stage Signup and view all the answers

Which type of penile tumor is associated with white changes, erythema, and ulcer?

Penile Intraepithelial Neoplasia Signup and view all the answers

Which type of penile neoplasm is most common and associated with low education, high poverty areas?

Squamous Cell Carcinoma Signup and view all the answers

Which risk factor is associated with the development of Squamous Cell Carcinoma?

Lichen sclerosis Signup and view all the answers

Which pathological finding is NOT typically associated with Squamous Cell Carcinoma?

Cuboidal cells Signup and view all the answers

Which treatment option is commonly used for penile cancer and may involve inguinal lymph node dissection?

Excision (partial / total penectomy) Signup and view all the answers

Which type of lesion is associated with sharply marginated, erythematous, scaly patch or plaque?

Bowen’s Disease Signup and view all the answers

Which genetic material is NOT degraded or inactivated in the pathogenesis of Squamous Cell Carcinoma?

E6 Signup and view all the answers

Which type of penile tumor has excellent prognosis, may recur, and is HPV negative with no P16 overexpression?

Verrucous Carcinoma Signup and view all the answers

Which cell type characterizes Verrucous Carcinoma, exhibiting slow growth and a verruciform tumor?

Well-differentiated squamous cells Signup and view all the answers

What is the characteristic pathologic finding in a seminoma?

Uniform tumor cells with clear cytoplasm Signup and view all the answers

Which of the following markers is typically elevated in seminoma?

Placental alkaline phosphatase (PLAP) Signup and view all the answers

What is a common feature seen in spermatocytic tumors that distinguishes them from classic seminomas?

Contains 3 cell types Signup and view all the answers

Which tumor type is associated with elevated hCG and Placental Alkaline Phosphatase (PLAP)?

Choriocarcinoma Signup and view all the answers

What is a common molecular characteristic of seminomas?

Overrepresentation of 12p chromosome sequences Signup and view all the answers

Which seral marker is typically abnormal in some seminomas?

LDH Signup and view all the answers

What is a poor prognostic factor in spermatocytic tumors?

Presence of sarcomatous components Signup and view all the answers

Which tumor type is associated with cytotrophoblast and syncytiotrophoblast components?