Testicular Anatomy and Tumors
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Questions and Answers

What is the major function of Sertoli cells?

  • Involved in lymphatic spread of testicular tumors
  • Located in interstitial tissue
  • Derived from 2 or 3 germ layers
  • Initiate spermatogenesis (correct)
  • Which layer of the testes forms the vascular layer?

  • Tunica vasculosa (correct)
  • Tunica vaginalis
  • Tunica of interstitial tissue
  • Tunica albuginea
  • What is the most common solid tumor in males aged 15-35?

  • Yolk sac tumor
  • Seminoma (correct)
  • Spermatocytic seminoma
  • Teratoma
  • Which nodes are NOT involved in the lymphatic spread of testicular tumors?

    <p>Inguinal nodes</p> Signup and view all the answers

    What is classical seminoma known to be?

    <p>Bilateral germ cell tumor</p> Signup and view all the answers

    Which of the following is a common risk factor for testicular germ cell tumors?

    <p>Family history</p> Signup and view all the answers

    What does an elevated AFP suggest in a testicular tumor?

    <p>Presence of yolk sac tumor components</p> Signup and view all the answers

    Where is intratubular germ cell neoplasia (ITGCN) commonly found?

    <p>Within the seminiferous epithelium</p> Signup and view all the answers

    What is one of the key factors affecting the prognosis of testicular tumors?

    <p>Histologic type and tumor stage</p> Signup and view all the answers

    Which type of penile tumor is associated with white changes, erythema, and ulcer?

    <p>Penile Intraepithelial Neoplasia</p> Signup and view all the answers

    Which type of penile neoplasm is most common and associated with low education, high poverty areas?

    <p>Squamous Cell Carcinoma</p> Signup and view all the answers

    Which risk factor is associated with the development of Squamous Cell Carcinoma?

    <p>Lichen sclerosis</p> Signup and view all the answers

    Which pathological finding is NOT typically associated with Squamous Cell Carcinoma?

    <p>Cuboidal cells</p> Signup and view all the answers

    Which treatment option is commonly used for penile cancer and may involve inguinal lymph node dissection?

    <p>Excision (partial / total penectomy)</p> Signup and view all the answers

    Which type of lesion is associated with sharply marginated, erythematous, scaly patch or plaque?

    <p>Bowen’s Disease</p> Signup and view all the answers

    Which genetic material is NOT degraded or inactivated in the pathogenesis of Squamous Cell Carcinoma?

    <p>E6</p> Signup and view all the answers

    Which type of penile tumor has excellent prognosis, may recur, and is HPV negative with no P16 overexpression?

    <p>Verrucous Carcinoma</p> Signup and view all the answers

    Which cell type characterizes Verrucous Carcinoma, exhibiting slow growth and a verruciform tumor?

    <p>Well-differentiated squamous cells</p> Signup and view all the answers

    What is the characteristic pathologic finding in a seminoma?

    <p>Uniform tumor cells with clear cytoplasm</p> Signup and view all the answers

    Which of the following markers is typically elevated in seminoma?

    <p>Placental alkaline phosphatase (PLAP)</p> Signup and view all the answers

    What is a common feature seen in spermatocytic tumors that distinguishes them from classic seminomas?

    <p>Contains 3 cell types</p> Signup and view all the answers

    Which tumor type is associated with elevated hCG and Placental Alkaline Phosphatase (PLAP)?

    <p>Choriocarcinoma</p> Signup and view all the answers

    What is a common molecular characteristic of seminomas?

    <p>Overrepresentation of 12p chromosome sequences</p> Signup and view all the answers

    Which seral marker is typically abnormal in some seminomas?

    <p>LDH</p> Signup and view all the answers

    What is a poor prognostic factor in spermatocytic tumors?

    <p>Presence of sarcomatous components</p> Signup and view all the answers

    Which tumor type is associated with cytotrophoblast and syncytiotrophoblast components?

    <p>Choriocarcinoma</p> Signup and view all the answers

    Which of the following markers is indicative of trophoblast differentiation in a tumor?

    <p>hCG</p> Signup and view all the answers

    What distinguishes spermatocytic tumors in terms of origin compared to classic seminomas?

    <p>Derived from intratubular germ cell neoplasia</p> Signup and view all the answers

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