Testicular Anatomy and Tumors

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Questions and Answers

What is the major function of Sertoli cells?

  • Involved in lymphatic spread of testicular tumors
  • Located in interstitial tissue
  • Derived from 2 or 3 germ layers
  • Initiate spermatogenesis (correct)

Which layer of the testes forms the vascular layer?

  • Tunica vasculosa (correct)
  • Tunica vaginalis
  • Tunica of interstitial tissue
  • Tunica albuginea

What is the most common solid tumor in males aged 15-35?

  • Yolk sac tumor
  • Seminoma (correct)
  • Spermatocytic seminoma
  • Teratoma

Which nodes are NOT involved in the lymphatic spread of testicular tumors?

<p>Inguinal nodes (C)</p> Signup and view all the answers

What is classical seminoma known to be?

<p>Bilateral germ cell tumor (B)</p> Signup and view all the answers

Which of the following is a common risk factor for testicular germ cell tumors?

<p>Family history (C)</p> Signup and view all the answers

What does an elevated AFP suggest in a testicular tumor?

<p>Presence of yolk sac tumor components (A)</p> Signup and view all the answers

Where is intratubular germ cell neoplasia (ITGCN) commonly found?

<p>Within the seminiferous epithelium (A)</p> Signup and view all the answers

What is one of the key factors affecting the prognosis of testicular tumors?

<p>Histologic type and tumor stage (A)</p> Signup and view all the answers

Which type of penile tumor is associated with white changes, erythema, and ulcer?

<p>Penile Intraepithelial Neoplasia (C)</p> Signup and view all the answers

Which type of penile neoplasm is most common and associated with low education, high poverty areas?

<p>Squamous Cell Carcinoma (A)</p> Signup and view all the answers

Which risk factor is associated with the development of Squamous Cell Carcinoma?

<p>Lichen sclerosis (D)</p> Signup and view all the answers

Which pathological finding is NOT typically associated with Squamous Cell Carcinoma?

<p>Cuboidal cells (C)</p> Signup and view all the answers

Which treatment option is commonly used for penile cancer and may involve inguinal lymph node dissection?

<p>Excision (partial / total penectomy) (D)</p> Signup and view all the answers

Which type of lesion is associated with sharply marginated, erythematous, scaly patch or plaque?

<p>Bowen’s Disease (A)</p> Signup and view all the answers

Which genetic material is NOT degraded or inactivated in the pathogenesis of Squamous Cell Carcinoma?

<p>E6 (A)</p> Signup and view all the answers

Which type of penile tumor has excellent prognosis, may recur, and is HPV negative with no P16 overexpression?

<p>Verrucous Carcinoma (A)</p> Signup and view all the answers

Which cell type characterizes Verrucous Carcinoma, exhibiting slow growth and a verruciform tumor?

<p>Well-differentiated squamous cells (B)</p> Signup and view all the answers

What is the characteristic pathologic finding in a seminoma?

<p>Uniform tumor cells with clear cytoplasm (B)</p> Signup and view all the answers

Which of the following markers is typically elevated in seminoma?

<p>Placental alkaline phosphatase (PLAP) (D)</p> Signup and view all the answers

What is a common feature seen in spermatocytic tumors that distinguishes them from classic seminomas?

<p>Contains 3 cell types (B)</p> Signup and view all the answers

Which tumor type is associated with elevated hCG and Placental Alkaline Phosphatase (PLAP)?

<p>Choriocarcinoma (B)</p> Signup and view all the answers

What is a common molecular characteristic of seminomas?

<p>Overrepresentation of 12p chromosome sequences (B)</p> Signup and view all the answers

Which seral marker is typically abnormal in some seminomas?

<p>LDH (D)</p> Signup and view all the answers

What is a poor prognostic factor in spermatocytic tumors?

<p>Presence of sarcomatous components (D)</p> Signup and view all the answers

Which tumor type is associated with cytotrophoblast and syncytiotrophoblast components?

<p>Choriocarcinoma (C)</p> Signup and view all the answers

Which of the following markers is indicative of trophoblast differentiation in a tumor?

<p>hCG (D)</p> Signup and view all the answers

What distinguishes spermatocytic tumors in terms of origin compared to classic seminomas?

<p>Derived from intratubular germ cell neoplasia (B)</p> Signup and view all the answers

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