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Questions and Answers
What are some symptoms of hemostasis disorders?
Which of the following is not an example of a hereditary hemostasis disorder?
What is thrombocytopenia?
Which of the following is a storage pool defect?
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What is a hemorrhagic disorder due to intrinsic pathway disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What is a lab evaluation of fibrinolysis that can be done through a protamine sulfate gelation test?
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Which of the following is an aggregation defect?
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What is the primary function of vitamin K in coagulation?
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What is the principle behind the whole blood clot lysis time test?
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Which test is more sensitive and rapid in measuring lytic activity, and avoids the problems that arise from plasminogen inhibitors?
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What is the principle behind the protamine sulfate gelation test?
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What is the difference between primary and secondary fibrinolysis?
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What is the reference range for the euglobulin lysis time test?
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What is the difference between the late D-dimer assay and the other tests?
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What is the normal platelet count in patients with hepatic disease and vitamin K deficiency?
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What are some symptoms of hemostasis disorders?
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What are some hereditary hemostasis disorders?
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What is thrombocytopenia?
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What is thrombocytosis?
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What are some adhesion defects?
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What are some intrinsic pathway disorders?
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What are some extrinsic and common pathway disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What are some hemorrhagic disorders due to intrinsic pathway disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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Which of the following is an example of a hereditary hemostasis disorder?
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What are some examples of adhesion defects?
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Which of the following is a hemorrhagic disorder due to extrinsic and common pathway disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What is a lab evaluation method for fibrinolysis?
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What is a hereditary hemostasis disorder that is not listed in the text?
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Which disorder is an uncontrolled proliferation of platelets?
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Which disorder is a quantitative platelet disorder?
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Which disorder is a qualitative platelet disorder that results in impaired platelet adhesion?
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Which disorder is a qualitative platelet disorder that results in impaired platelet aggregation?
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Which disorder is a storage pool defect that results in gray platelets?
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Which disorder is a hemorrhagic disorder due to a deficiency in factor IX?
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Which disorder is an acquired disorder of coagulation and fibrinolysis that can be caused by vitamin K deficiency?
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Which test can be used to evaluate fibrinolysis through whole blood clot lysis time?
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What are some symptoms of hemostasis disorders?
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Which of the following is an example of a hereditary hemostasis disorder?
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What is thrombocytopenia?
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Which of the following is an example of an adhesion defect of platelets?
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What is the cause of thrombocytosis?
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Which of the following is an example of a hemorrhagic disorder due to intrinsic pathway disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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How can lab evaluation of fibrinolysis be done?
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What are some symptoms of hemostasis disorders?
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Which of the following is an example of a hereditary hemostasis disorder?
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What is thrombocytopenia?
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Which of the following is a storage pool defect of platelets?
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What are intrinsic pathway disorders that can cause hemorrhagic disorders?
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What can cause acquired disorders of coagulation and fibrinolysis?
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What is the lab evaluation used to assess fibrinolysis?
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Which of the following is an acquired hemostasis disorder?
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What are some symptoms of hemostasis disorders?
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Which of the following is an example of a hereditary hemostasis disorder?
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What is thrombocytopenia and what are some possible causes?
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What are adhesion defects in hemostasis disorders?
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What is a hemorrhagic disorder due to intrinsic pathway disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What is a lab evaluation method for fibrinolysis?
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Which of the following is an acquired hemostasis disorder?
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What are some symptoms of hemostasis disorders?
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What are some examples of hereditary hemostasis disorders?
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What is thrombocytopenia?
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What are some examples of adhesion defects of platelets?
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What are some intrinsic pathway disorders that can cause hemorrhagic disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What is the lab evaluation of fibrinolysis?
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What is thrombocytosis?
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Which hereditary disorder can cause hemostasis disorders?
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What is a common quantitative platelet disorder?
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Which disorder includes uncontrolled proliferation of platelets?
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Which adhesion defect disorder is caused by a deficiency in von Willebrand factor?
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Which intrinsic pathway disorder can cause hemostasis disorders?
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Which acquired disorder can cause fibrinolysis?
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Which lab evaluation can be used to test fibrinolysis?
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Which acquired hemostasis disorder is caused by a deficiency of vitamin K?
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Which hereditary disorder is NOT mentioned as a cause of hemostasis disorders in the text?
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Which of the following is NOT a symptom of hemostasis disorders mentioned in the text?
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What is the most common cause of thrombocytopenia according to the text?
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Which disorder is NOT mentioned as an adhesion defect in the text?
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What is the most common cause of thrombocytosis according to the text?
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Which intrinsic pathway disorder is NOT mentioned as a cause of hemorrhagic disorders in the text?
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Which acquired disorder is NOT mentioned as a cause of coagulation and fibrinolysis disorders in the text?
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Which test is NOT mentioned as a way to evaluate fibrinolysis in the text?
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What are some symptoms that can be presented by hemostasis disorders?
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What are some examples of hereditary hemostasis disorders?
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What is thrombocytopenia and what are some of its causes?
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What are some examples of platelet adhesion defects?
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What are some intrinsic pathway disorders that can cause hemorrhagic disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What are some lab evaluation methods for fibrinolysis?
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What is thrombocytosis and how can it occur?
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What are some symptoms of hemostasis disorders?
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Which of the following is an example of a hereditary hemostasis disorder?
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What is thrombocytopenia?
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What are some examples of adhesion defects?
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What are some intrinsic pathway disorders that can cause hemorrhagic disorders?
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What are some acquired disorders of coagulation and fibrinolysis?
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What are some lab evaluations of fibrinolysis?
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What is thrombocytosis?
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What are some symptoms of hemostasis disorders?
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What are some hereditary vascular defects that can cause hemostasis disorders?
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What are some acquired alterations of vessel wall structure that can cause hemostasis disorders?
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What can lead to hypercoagulation or hypocoagulation in hemostasis disorders?
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What can cause autoimmune vascular purpura in hemostasis disorders?
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What are some quantitative platelet disorders that can cause hemostasis disorders?
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What are some qualitative platelet disorders that can cause hemostasis disorders?
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What are some disorders of thrombosis that can cause hemostasis disorders?
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What are some symptoms of hemostasis disorders?
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What are some hereditary vascular defects?
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What can cause acquired alterations of vessel wall structure?
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What can lead to hypercoagulation or hypocoagulation?
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What can cause autoimmune vascular purpura?
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What are some causes of quantitative platelet disorders?
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What is thrombocytosis?
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What are some examples of qualitative platelet disorders?
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Study Notes
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can present with various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematoma, hematemesis, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary hemostasis disorders include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata (Kasabach-Merritt syndrome).
- Acquired hemostasis disorders include scurvy, senile purpura, diabetes mellitus, amyloidosis, and autoimmune vascular purpura.
- Platelet disorders can be quantitative or qualitative, with thrombocytopenia being a common quantitative disorder.
- Thrombocytopenia can be caused by decreased production, dilutional loss, non-immune destruction, immune destruction, disseminated intravascular coagulation, TTP, or increased platelet sequestration by the spleen.
- Thrombocytosis is an uncontrolled proliferation of platelets and can be primary or secondary.
- Adhesion defects include Bernard-Soulier syndrome and von Willebrand's disease, while aggregation defects include Glanzmann's thrombasthenia and afibrinogenemia.
- Storage pool defects include gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Hemorrhagic disorders due to intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency (hemophilia A), factor IX deficiency (hemophilia B), and von Willebrand's disease.
- Hemorrhagic disorders due to extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II (prothrombin) deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary fibrinogenolysis, and secondary fibrinogenolysis.
- Lab evaluation of fibrinolysis can be done through whole blood clot lysis time, euglobulin lysis time, protamine sulfate gelation test, ethanol gelation test, and latex D-dimer assay.
Overview of Hemostasis Disorders
- Hemostasis disorders can cause various symptoms such as petechiae, purpura, ecchymosis, epistaxis, hemarthrosis, hematemesis, hematoma, hematuria, hemoglobinuria, hemoptysis, melena, and menorrhagia.
- Hereditary vascular defects include Ehlers-Danlos syndrome, pseudoxanthoma elasticum, hereditary hemorrhagic telangiectasia, and congenital hemangiomata.
- Acquired alterations of vessel wall structure can be caused by diseases such as diabetes mellitus and amyloidosis.
- Endothelial damage caused by autoimmune or infectious agents can lead to hypercoagulation or hypocoagulation.
- Autoimmune vascular purpura can be caused by drugs, allergies, or infections.
- Quantitative platelet disorders include thrombocytopenia caused by decreased production, dilutional loss, nonimmune or immune destruction, disseminated intravascular coagulation, thrombotic thrombocytopenic purpura, and increased platelet sequestration.
- Thrombocytosis can be primary or secondary.
- Qualitative platelet disorders include adhesion defects such as Bernard-Soulier syndrome and von Willebrand's disease, aggregation defects such as Glanzmann's thrombasthenia and afibrinogenemia, and storage pool defects such as gray platelet syndrome, Wiskott-Aldrich syndrome, Hermansky-Pudlak syndrome, and Chediak-Higashi syndrome.
- Disorders of thrombosis can be primary or secondary, and include antithrombin-III deficiency, protein C and S deficiency, fibrinolytic system disorders, dysfibrinogenemia, and homocystinuria.
- Hemorrhagic disorders in intrinsic pathway disorders include factor XI deficiency, factor VIII:C deficiency, factor IX deficiency, and von Willebrand's disease.
- Hemorrhagic disorders in extrinsic and common pathway disorders include factor VII deficiency, factor X deficiency, factor V deficiency, factor II deficiency, factor I deficiency, and factor XIII deficiency.
- Acquired disorders of coagulation and fibrinolysis include hepatic disease, vitamin K deficiency, disseminated intravascular coagulation, primary and secondary fibrinogenolysis, and lab evaluation of fibrinolysis.
- Anticoagulant therapy with heparin or warfarin requires monitoring of the patient's antithrombin III assay, platelet count, and D-dimer levels. Treatment for these disorders may include replacement therapy, anticoagulant therapy, or supportive care.
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