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Questions and Answers
Which type of vessels are thrombi composed mainly of?
Which type of vessels are thrombi composed mainly of?
In which patients is the use of aspirin in primary prevention of cardiovascular disease not recommended?
In which patients is the use of aspirin in primary prevention of cardiovascular disease not recommended?
When is long-term use of low-dose aspirin recommended?
When is long-term use of low-dose aspirin recommended?
What must be controlled before aspirin is given to a patient?
What must be controlled before aspirin is given to a patient?
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What can be added if a patient is at a high risk of gastro-intestinal bleeding?
What can be added if a patient is at a high risk of gastro-intestinal bleeding?
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In which condition is aspirin given following coronary bypass surgery?
In which condition is aspirin given following coronary bypass surgery?
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For what condition is clopidogrel used in combination with low-dose aspirin?
For what condition is clopidogrel used in combination with low-dose aspirin?
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When should aspirin monotherapy be considered following transcatheter aortic valve implantation (TAVI)?
When should aspirin monotherapy be considered following transcatheter aortic valve implantation (TAVI)?
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What is the alternative to aspirin if it is not tolerated?
What is the alternative to aspirin if it is not tolerated?
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What is the risk of bleeding when using clopidogrel with aspirin?
What is the risk of bleeding when using clopidogrel with aspirin?
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Which antiplatelet drug is recommended in addition to aspirin for at least 1 month after placement of a bare-metal stent?
Which antiplatelet drug is recommended in addition to aspirin for at least 1 month after placement of a bare-metal stent?
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Which antiplatelet drug is licensed for secondary prevention of ischaemic stroke and transient ischaemic attacks?
Which antiplatelet drug is licensed for secondary prevention of ischaemic stroke and transient ischaemic attacks?
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Which antiplatelet drug, in combination with aspirin, is licensed for the prevention of atherothrombotic events in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
Which antiplatelet drug, in combination with aspirin, is licensed for the prevention of atherothrombotic events in patients with acute coronary syndrome undergoing percutaneous coronary intervention?
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Which antiplatelet drug, in combination with aspirin, is licensed for the prevention of atherothrombotic events in patients with acute coronary syndrome?
Which antiplatelet drug, in combination with aspirin, is licensed for the prevention of atherothrombotic events in patients with acute coronary syndrome?
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Which antiplatelet drug, in combination with aspirin, is licensed for the reduction of thrombotic cardiovascular events in patients with coronary artery disease undergoing percutaneous coronary intervention?
Which antiplatelet drug, in combination with aspirin, is licensed for the reduction of thrombotic cardiovascular events in patients with coronary artery disease undergoing percutaneous coronary intervention?
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Which antiplatelet drug is recommended to be used under expert supervision only?
Which antiplatelet drug is recommended to be used under expert supervision only?
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Which antiplatelet drug should be used indefinitely in patients selected for percutaneous coronary intervention with the placement of a coronary stent?
Which antiplatelet drug should be used indefinitely in patients selected for percutaneous coronary intervention with the placement of a coronary stent?
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Which glycoprotein IIb/IIIa inhibitor is licensed for use as an adjunct to heparin and aspirin for the prevention of ischaemic complications in high-risk patients undergoing percutaneous transluminal coronary intervention?
Which glycoprotein IIb/IIIa inhibitor is licensed for use as an adjunct to heparin and aspirin for the prevention of ischaemic complications in high-risk patients undergoing percutaneous transluminal coronary intervention?
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Which glycoprotein IIb/IIIa inhibitor is licensed for use to prevent early myocardial infarction in patients with unstable angina or non-ST-segment-elevation myocardial infarction?
Which glycoprotein IIb/IIIa inhibitor is licensed for use to prevent early myocardial infarction in patients with unstable angina or non-ST-segment-elevation myocardial infarction?
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Which glycoprotein IIb/IIIa inhibitor is licensed for use in combination with heparin, aspirin, and clopidogrel, for the reduction of major cardiovascular events in patients with ST-segment elevation myocardial infarction intended for primary percutaneous coronary intervention?
Which glycoprotein IIb/IIIa inhibitor is licensed for use in combination with heparin, aspirin, and clopidogrel, for the reduction of major cardiovascular events in patients with ST-segment elevation myocardial infarction intended for primary percutaneous coronary intervention?
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Study Notes
Thrombi Composition and Types
- Thrombi primarily consist of red blood cells, platelets, and fibrin strands.
Aspirin Use in Cardiovascular Disease Prevention
- Aspirin is not recommended for primary prevention in patients with a low risk of cardiovascular disease.
Long-term Aspirin Use Recommendations
- Long-term use of low-dose aspirin is recommended for patients with established cardiovascular disease.
Pre-administration Considerations
- Before administering aspirin, patients must have their bleeding risk controlled, particularly in those with active bleeding or gastrointestinal issues.
Gastrointestinal Bleeding Risks
- In patients at high risk for gastrointestinal bleeding, a proton pump inhibitor (PPI) may be added to the treatment regimen.
Aspirin Post-Coronary Bypass Surgery
- Aspirin is administered after coronary bypass surgery to reduce the risk of thromboembolic events.
Clopidogrel Combination Use
- Clopidogrel is used in combination with low-dose aspirin for patients post-percutaneous coronary intervention (PCI).
TAVI Aspiration Monotherapy Considerations
- Aspirin monotherapy should be considered after transcatheter aortic valve implantation (TAVI) in specific patients based on their bleeding risk profile.
Alternatives to Aspirin
- If aspirin is not tolerated, patients may be switched to clopidogrel as an alternative antiplatelet therapy.
Bleeding Risks with Combined Antiplatelet Therapy
- The risk of bleeding increases significantly when clopidogrel is used in conjunction with aspirin.
Bare-Metal Stent Recommendations
- Clopidogrel is recommended in addition to aspirin for at least a month after the placement of a bare-metal stent.
Ischaemic Stroke and TIA Management
- Clopidogrel is licensed for secondary prevention of ischaemic strokes and transient ischaemic attacks (TIA).
Acute Coronary Syndrome and PCI
- For patients with acute coronary syndrome undergoing PCI, the combination of clopidogrel and aspirin is licensed to prevent atherothrombotic events.
Ongoing Aspirin and Clopidogrel Use
- In acute coronary syndrome patients, clopidogrel with aspirin is also licensed for preventing atherothrombotic events and myocardial infarction.
Expert-supervised Antiplatelet Therapy
- Ticagrelor is an antiplatelet drug recommended for use under expert supervision only.
Indefinite Antiplatelet Therapy
- Patients receiving percutaneous coronary intervention with stent placement should be prescribed clopidogrel indefinitely.
Glycoprotein IIb/IIIa Inhibitors
- Eptifibatide is licensed for use as an adjunct to heparin and aspirin for ischaemic complication prevention in high-risk patients undergoing PCI.
- Tirofiban is licensed to prevent early myocardial infarction in unstable angina or non-ST-segment elevation myocardial infarction patients.
- Abciximab is indicated for use along with heparin, aspirin, and clopidogrel for reducing major cardiovascular events in ST-segment elevation myocardial infarction patients intended for primary PCI.
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Description
Quiz: Antiplatelet Drugs and Cardiovascular Disease Prevention Test your knowledge on antiplatelet drugs and their role in preventing cardiovascular disease. Learn about their mechanism of action, their effectiveness in inhibiting thrombus formation, and their use in primary prevention. Find out why the use of aspirin in certain patient populations is not recommended, and discover the benefits of long-term, low-dose aspirin therapy.
