Temperature Regulation II: Pathologies and Mechanisms

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What is the role of the hypothalamus in thermoregulation?

It acts as the thermostat for the body temperature

What happens beyond a body temperature of 42°C?

Cytotoxicity occurs with protein denaturation and impaired DNA synthesis

What are the potential consequences of severe hypothermia?

Neuromuscular, cardiovascular, hematological, and respiratory changes with fatal outcomes

How does fetal body temperature compare to maternal body temperature?

Fetal body temperature is usually 0.6 °C above maternal body temperature

What is the main function of thermoregulation in neonates?

Maintaining normal body temperature in a new harsh environment

What is the limit beyond which cytotoxicity occurs with protein denaturation and impaired DNA synthesis?

42°C

What is the potential fatality associated with severe hypothermia?

Respiratory failure

What is the usual difference between fetal body temperature and maternal body temperature?

0.6°C

What is the role of the hypothalamus in thermoregulation?

It regulates body temperature

What is the mechanism by which thermoregulation is impaired beyond normal temperature values?

Denaturation of proteins

What is the main function of neurons?

Generating and transmitting electrical signals

What is the main function of neuroglial cells?

Supporting and protecting neurons

Where are most neuronal cell bodies located?

Within the central nervous system (CNS)

What is the main function of the cell body of a neuron?

Acting as a 'protein factory' and containing the nucleus

What is the main function of dendrites in a neuron?

Receiving incoming signals from other neurons

This lecture covers the pathologies of heat and cold stresses, the differences between hyperthermia and fever, mechanisms of fever development, and human adaptation to extreme temperatures. It also includes a recap of thermoregulation as a homeostatic mechanism.

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