Podcast
Questions and Answers
What is the structure of the TCR composed of?
What is the structure of the TCR composed of?
- Alpha chain and beta chain, each having a Variable and Constant region (correct)
- Beta chain only
- Alpha chain only
- Variable region only
Where does somatic recombination of the TCR take place?
Where does somatic recombination of the TCR take place?
- Spleen
- Thymus (correct)
- Bone marrow
- Liver
What is the role of Artemis in TCR V(D)J recombination?
What is the role of Artemis in TCR V(D)J recombination?
- Transcribes and translates TCR
- Opens the DNA hairpins (correct)
- Flanks the V, D, and J segments
- Adds non-coded nucleotides
In what location are the D segments flanked by RSS in the TCR beta chain?
In what location are the D segments flanked by RSS in the TCR beta chain?
Which segment in BCR Ig heavy chain has two RSS with 12-bp spacing?
Which segment in BCR Ig heavy chain has two RSS with 12-bp spacing?
What leads to the combinatorial diversity of the TCR at the germline DNA level?
What leads to the combinatorial diversity of the TCR at the germline DNA level?
'CDRs' refer to:
'CDRs' refer to:
How many CDRs per chain confer specificity to the binding site?
How many CDRs per chain confer specificity to the binding site?
Which part of the gene becomes methylated and inaccessible to transcription machinery in allelic exclusion of B cells?
Which part of the gene becomes methylated and inaccessible to transcription machinery in allelic exclusion of B cells?
Why do B cells and T cells share the enzymatic machinery for generating antigen receptor diversity?
Why do B cells and T cells share the enzymatic machinery for generating antigen receptor diversity?
What is the initial primary B cell receptor expressed by newly formed B cells?
What is the initial primary B cell receptor expressed by newly formed B cells?
How does a B cell switch from producing IgM to IgD?
How does a B cell switch from producing IgM to IgD?
Which of the following is NOT an isotype of heavy chains for Immunoglobulins?
Which of the following is NOT an isotype of heavy chains for Immunoglobulins?
Where do B cells undergo processes like somatic hypermutation and class switching?
Where do B cells undergo processes like somatic hypermutation and class switching?
'Class Switch Recombination' switches the class of Immunoglobulins without changing which region?
'Class Switch Recombination' switches the class of Immunoglobulins without changing which region?
'Affinity maturation' creates higher affinity for antigens while preserving what property?
'Affinity maturation' creates higher affinity for antigens while preserving what property?
'Germinal Center' is responsible for what key processes in B cells?
'Germinal Center' is responsible for what key processes in B cells?
What is the role of somatic hypermutation in B cells?
What is the role of somatic hypermutation in B cells?
Which process leads to the selection of mutations for increased affinity to antigens?
Which process leads to the selection of mutations for increased affinity to antigens?
What is the main function of class switching in B cells?
What is the main function of class switching in B cells?
Which cytokine is critical for driving the production of IgE?
Which cytokine is critical for driving the production of IgE?
Which type of infection is INF gamma critical for in driving IgG2 and IgG3 production?
Which type of infection is INF gamma critical for in driving IgG2 and IgG3 production?
In class switching, what regions guide the process located upstream of each C gene?
In class switching, what regions guide the process located upstream of each C gene?
Which protein plays a role in class switching in B cells?
Which protein plays a role in class switching in B cells?
What is the primary outcome of affinity maturation in B cells?
What is the primary outcome of affinity maturation in B cells?
'Only occurs after B cell activation', 'irreversible', and 'guided by switch regions' are characteristics associated with which process?
'Only occurs after B cell activation', 'irreversible', and 'guided by switch regions' are characteristics associated with which process?
