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Questions and Answers
What determines the activities of the dehydrogenases of the TCA cycle?
What determines the activities of the dehydrogenases of the TCA cycle?
- Regulation by citrate synthase
- Continuous supply of NAD and FAD (correct)
- Availability of oxygen
- Presence of ATP
What is crucial in determining the rate of the TCA cycle?
What is crucial in determining the rate of the TCA cycle?
- Regulation of citrate synthase activity
- Supply of acetyl units from pyruvate or fatty acids (correct)
- Transport of NAD and FAD into mitochondria
- Inhibition of the respiratory chain
What is the regulatory process called that couples the activity of the respiratory chain to the generation of ATP?
What is the regulatory process called that couples the activity of the respiratory chain to the generation of ATP?
- Respiratory control (correct)
- Pyruvate dehydrogenase regulation
- Citrate synthase coupling
- Glycolytic regulation
What is strongly dependent on the rate of ATP synthesis?
What is strongly dependent on the rate of ATP synthesis?
What is an effective determinant of the TCA cycle activity?
What is an effective determinant of the TCA cycle activity?
What is the crucial factor in determining the rate of the TCA cycle?
What is the crucial factor in determining the rate of the TCA cycle?
What is an effective determinant of TCA cycle activity?
What is an effective determinant of TCA cycle activity?
What determines the activities of the dehydrogenases of the TCA cycle?
What determines the activities of the dehydrogenases of the TCA cycle?
What is the regulatory process called that couples the activity of the respiratory chain to the generation of ATP?
What is the regulatory process called that couples the activity of the respiratory chain to the generation of ATP?
What is the TCA cycle activity very dependent on?
What is the TCA cycle activity very dependent on?
Study Notes
Regulation of TCA Cycle
- The activities of the dehydrogenases of the TCA cycle are determined by the NAD+/NADH and FAD/FADH2 ratios.
- The rate of the TCA cycle is crucially determined by the availability of NAD+ and CoA-SH.
- The regulatory process that couples the activity of the respiratory chain to the generation of ATP is called respiratory control.
- The rate of ATP synthesis is strongly dependent on the proton gradient across the inner mitochondrial membrane.
- The availability of NAD+ and CoA-SH is an effective determinant of the TCA cycle activity.
- The crucial factor in determining the rate of the TCA cycle is the availability of NAD+ and CoA-SH.
- The TCA cycle activity is very dependent on the ATP/ADP ratio, which affects the activity of isocitrate dehydrogenase and alpha-ketoglutarate dehydrogenase.
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Description
Test your knowledge of the regulation of the Tricarboxylic Acid (TCA) cycle with this quiz. Explore the factors that control the supply of acetyl units and the regulation of key enzymes involved in the cycle.