Podcast
Questions and Answers
What is the primary mechanism by which Tadalafil produces an erection?
What is the primary mechanism by which Tadalafil produces an erection?
- Increased production of testosterone
- Inhibition of smooth muscle relaxation
- Direct stimulation of nerve endings
- Activation of guanylyl cyclase by nitric oxide (correct)
What is the recommended starting dose of Intimate™ for use as needed in most patients?
What is the recommended starting dose of Intimate™ for use as needed in most patients?
- 10 mg (correct)
- 5 mg
- 2.5 mg
- 20 mg
Which condition is Intimate™ NOT indicated for?
Which condition is Intimate™ NOT indicated for?
- Hypertension (correct)
- ED with BPH
- Erectile dysfunction (ED)
- Benign prostatic hyperplasia (BPH)
What is the maximum recommended dosing frequency of Intimate™ for use as needed?
What is the maximum recommended dosing frequency of Intimate™ for use as needed?
For patients using Intimate™ for benign prostatic hyperplasia (BPH), what is the recommended once daily dose?
For patients using Intimate™ for benign prostatic hyperplasia (BPH), what is the recommended once daily dose?
What effect does Tadalafil have on penile blood flow without sexual stimulation?
What effect does Tadalafil have on penile blood flow without sexual stimulation?
For patients with mild renal insufficiency, what adjustment is needed for the as-needed dose of Intimate™?
For patients with mild renal insufficiency, what adjustment is needed for the as-needed dose of Intimate™?
What happens to cGMP levels in the corpus cavernosum after Tadalafil inhibits PDE5?
What happens to cGMP levels in the corpus cavernosum after Tadalafil inhibits PDE5?
What cardiovascular consideration should physicians keep in mind regarding patients taking tadalafil?
What cardiovascular consideration should physicians keep in mind regarding patients taking tadalafil?
What is a rare, serious side effect associated with tadalafil use?
What is a rare, serious side effect associated with tadalafil use?
What is the maximum recommended dose of tadalafil for patients with severe renal impairment (creatinine clearance <30 mL/min)?
What is the maximum recommended dose of tadalafil for patients with severe renal impairment (creatinine clearance <30 mL/min)?
What should be done regarding tadalafil dosing in patients aged over 65 years?
What should be done regarding tadalafil dosing in patients aged over 65 years?
Which condition requires caution when using tadalafil due to the risk of priapism?
Which condition requires caution when using tadalafil due to the risk of priapism?
What should patients do if they experience sudden loss of vision while taking tadalafil?
What should patients do if they experience sudden loss of vision while taking tadalafil?
In which scenario is tadalafil contraindicated?
In which scenario is tadalafil contraindicated?
How should tadalafil be administered to patients taking nitrates?
How should tadalafil be administered to patients taking nitrates?
What potential interaction should physicians be aware of when prescribing tadalafil with alpha-blockers?
What potential interaction should physicians be aware of when prescribing tadalafil with alpha-blockers?
What dosing adjustment is recommended for mild or moderate hepatic impairment when using tadalafil as needed?
What dosing adjustment is recommended for mild or moderate hepatic impairment when using tadalafil as needed?
In which patients should tadalafil be used with caution due to the risk of prolonged erections?
In which patients should tadalafil be used with caution due to the risk of prolonged erections?
What cardiovascular side effects have been associated with tadalafil use?
What cardiovascular side effects have been associated with tadalafil use?
What are some gastrointestinal side effects associated with the use of certain medications mentioned?
What are some gastrointestinal side effects associated with the use of certain medications mentioned?
Why should physicians be cautious about prescribing tadalafil to children or newborns?
Why should physicians be cautious about prescribing tadalafil to children or newborns?
What is the dosing recommendation for tadalafil in patients with moderate renal impairment (creatinine clearance 31 to 50 mL/min)?
What is the dosing recommendation for tadalafil in patients with moderate renal impairment (creatinine clearance 31 to 50 mL/min)?
Which side effect is not typically associated with tadalafil?
Which side effect is not typically associated with tadalafil?
Flashcards
Tadalafil's effect on cGMP
Tadalafil's effect on cGMP
Tadalafil inhibits the enzyme PDE5, which degrades cGMP. This leads to higher cGMP levels.
Erectile Dysfunction (ED) treatment
Erectile Dysfunction (ED) treatment
Intimate™ is used to treat ED by increasing cGMP levels, relaxing smooth muscles, and improving blood flow to the penis.
Intimate™ 5mg dosage
Intimate™ 5mg dosage
A starting dose for on-demand use for ED, the lowest.
Intimate™ 10mg dosage
Intimate™ 10mg dosage
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Intimate™ 20mg dosage
Intimate™ 20mg dosage
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Intimate™ once daily use
Intimate™ once daily use
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Benign Prostatic Hyperplasia (BPH)
Benign Prostatic Hyperplasia (BPH)
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Intimate™ for BPH
Intimate™ for BPH
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Hyperhidrosis
Hyperhidrosis
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Gastrointestinal issues
Gastrointestinal issues
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Migraine
Migraine
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Transient Global Amnesia
Transient Global Amnesia
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Epistaxis
Epistaxis
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Priapism
Priapism
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Sudden vision loss ,hearing loss
Sudden vision loss ,hearing loss
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Potential Drug Interactions
Potential Drug Interactions
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Tadalafil Dose (Renal Impairment)
Tadalafil Dose (Renal Impairment)
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Tadalafil Dose (Hepatic Impairment)
Tadalafil Dose (Hepatic Impairment)
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Tadalafil (Geriatric Use)
Tadalafil (Geriatric Use)
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Tadalafil Food Interaction
Tadalafil Food Interaction
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Tadalafil Contraindication (Nitrates)
Tadalafil Contraindication (Nitrates)
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Tadalafil Contraindication (Hypersensitivity)
Tadalafil Contraindication (Hypersensitivity)
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Potential Cardiovascular Side Effects
Potential Cardiovascular Side Effects
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Hypersensitivity Side Effects
Hypersensitivity Side Effects
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Study Notes
Composition
- Intimate™ 5 mg tablets contain 5 mg tadalafil.
- Intimate™ 10 mg tablets contain 10 mg tadalafil.
- Intimate™ 20 mg tablets contain 20 mg tadalafil.
Pharmacology
- Tadalafil inhibits PDE5, increasing cGMP levels in the corpus cavernosum.
- This relaxation of smooth muscle allows blood flow into the penis for an erection.
- Tadalafil has no effect on blood flow without sexual stimulation.
Indication
- Tadalafil is used to treat erectile dysfunction (ED).
- It's also used to treat symptoms of benign prostatic hyperplasia (BPH).
- Combined treatment for both ED and BPH is available.
Dosage and Administration
For Use as Needed
- Starting dose is typically 10mg, taken before sexual activity.
- Dose may be adjusted to 20mg or 5mg based on individual response.
- Maximum frequency is once per day.
For Once Daily Use
- Starting dose is 2.5 mg taken daily, regardless of sexual activity schedule.
- Dose may be increased to 5mg based on individual response.
Renal Insufficiency
For Use as Needed
- Mild: No dose adjustment is needed.
- Moderate: Initial dose of 5 mg per day, maximum 10 mg every 48 hours.
- Severe: Maximum dose 5 mg every 72 hours.
For Once Daily Use
- Mild and Moderate: No adjustment required.
- Severe: Not recommended.
Hepatic Impairment
For Use as Needed
- Mild or Moderate: Maximum daily dose is 10 mg.
- Severe: Not recommended.
For Once Daily Use
- Mild to Moderate: Use with caution.
- Severe: Not recommended.
Geriatrics
- No dose adjustment is needed for patients over 65 years old.
Use with Food
- Tadalafil can be taken with or without food.
Contraindications
- Do not take tadalafil if you are using nitrates (e.g., nitroglycerin) as it can lower blood pressure dangerously.
Hypersensitivity Reactions
- Tadalafil can cause serious allergic reactions (Stevens-Johnson syndrome, exfoliative dermatitis).
- It is contraindicated for patients with known serious hypersensitivity to tadalafil.
Side Effects
- Possible side effects include: cardiovascular events, hypotension, hypertension, syncope, rash, urticaria, facial edema, Stevens-Johnson syndrome, exfoliative dermatitis, hyperhidrosis, abdominal pain, gastroesophageal reflux, migraine, transient global amnesia, epistaxis, blurred vision, nonarteritic anterior ischemic optic neuropathy, retinal vein occlusion, visual field defects, sudden decrease or loss of hearing.
Pregnancy and Lactation
- Tadalafil is not indicated for use in newborns, children, or women who are pregnant or breastfeeding.
Warnings and Precautions
- Monitor cardiovascular status of patients, especially those with pre-existing conditions.
- Be aware of potential drug interactions with nitrates, alpha-blockers, and antihypertensives, particularly for once-daily use.
- Be cautious in renal or hepatic impairment.
- Monitor for prolonged erections (priapism).
Overdosage
- Adverse events may resemble those observed at lower doses, and standard supportive measures should be taken.
Storage
- Store below 30°C, protected from light and moisture.
How Supplied
- Different strengths of tablets are available in various packaging sizes.
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Description
This quiz covers the pharmacology, dosages, and indications for Tadalafil, a medication used for treating erectile dysfunction and benign prostatic hyperplasia. Test your knowledge on how Tadalafil functions, its effective dosages, and clinical applications.
